感染8型人类疱疹病毒后的DNA阳性与低胰岛素分泌相关:一项对撒哈拉沙漠以南的非洲糖尿病患者的病例对照研究

Translated title of the contribution: Human herpesvirus 8 infection DNA positivity is associated with low insulin secretion: A case-control study in a sub-Saharan African population with diabetes

Eric Lontchi-Yimagou, Jérôme Legoff, Jean Louis Nguewa, Philippe Boudou, Eric V. Balti, Jean J. Noubiap, Vicky Kamwa, Barbara Atogho-Tiedeu, Marcel Azabji-Kenfack, Eric N. Djahmeni, Martine Etoa, Gaelle Lemdjo, Vanessa Balla, Mesmin Y. Dehayem, Fabienne Foufelle, Jean Claude Mbanya, Jean Francois Gautier, Eugene Sobngwi

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Background: Viruses have been considered potential triggers for the development of diabetes. This study assessed insulin secretion and insulin sensitivity in human herpesvirus 8 (HHV8)-infected and uninfected sub-Saharan African people with diabetes. Methods: In all, 173 people with non-autoimmune diabetes were enrolled consecutively: 124 with type 2 diabetes mellitus (T2DM) and 49 with ketosis-prone diabetes (KPD) admitted in hyperglycemic crisis. Those with KPD were further subdivided into those with new-onset ketotic-phase KPD (n = 34) or non-ketotic phase KPD (n = 15). All participants were screened for HHV8-specific antibodies and genomic DNA. Blood samples were collected for analysis of fasting glucose, HbA1c, lipid profile, and C-peptide, with insulin resistance and secretion estimated by homeostasis model assessment. Results: Among the 173 diabetic participants, 88 (50.9%) were positive for HHV8 antibodies (Ac-HHV8+), including 15 (8.7%) positive for HHV8 DNA (DNA-HHV8+). The seroprevalence of HHV8 was similar between T2DM (55.6%) and KPD (61.2%) subjects. Of those with and without ketotic-phase KPD, 35.3% and 46.7% were Ac-HHV8+, respectively. Body mass index was significantly in lower DNA-HHV8+ than DNA-HHV8– subjects. Low-density lipoprotein and total cholesterol were significantly higher, but C-peptide and homeostatic model assessment of β-cell function (HOMA-β) were significantly lower in DNA-HHV8+ than DNA-HHV8– participants. After excluding DNA-HHV8+ participants, triglyceride concentrations were significantly higher in Ac-HHV8+ (n = 73) than Ac-HHV8– (n = 85) subjects. In contrast, HOMA-β was significantly higher among Ac-HHV8+ than Ac-HHV8– participants. Conclusions: In the present study, HHV8 DNA positivity was associated with low insulin secretion in this sub-Saharan African diabetes population.

Translated title of the contributionHuman herpesvirus 8 infection DNA positivity is associated with low insulin secretion: A case-control study in a sub-Saharan African population with diabetes
Original languageChinese (Traditional)
Pages (from-to)866-873
Number of pages8
JournalJournal of Diabetes
Volume10
Issue number11
DOIs
StatePublished - Nov 2018
Externally publishedYes

Keywords

  • human herpesvirus type 8
  • insulin resistance
  • insulin secretion
  • ketosis-pronediabetes
  • type 2 diabetes

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

Fingerprint

Dive into the research topics of 'Human herpesvirus 8 infection DNA positivity is associated with low insulin secretion: A case-control study in a sub-Saharan African population with diabetes'. Together they form a unique fingerprint.

Cite this