Human fear-related motor neurocircuitry

T. Butler, H. Pan, O. Tuescher, A. Engelien, M. Goldstein, J. Epstein, D. Weisholtz, J. C. Root, X. Protopopescu, A. C. Cunningham-Bussel, L. Chang, Xianhong Xie, Q. Chen, E. A. Phelps, J. E. Ledoux, E. Stern, D. A. Silbersweig

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

Using functional magnetic resonance imaging and an experimental paradigm of instructed fear, we observed a striking pattern of decreased activity in primary motor cortex with increased activity in dorsal basal ganglia during anticipation of aversive electrodermal stimulation in 42 healthy participants. We interpret this pattern of activity in motor neurocircuitry in response to cognitively-induced fear in relation to evolutionarily-conserved responses to threat that may be relevant to understanding normal and pathological fear in humans.

Original languageEnglish (US)
Pages (from-to)1-7
Number of pages7
JournalNeuroscience
Volume150
Issue number1
DOIs
StatePublished - Nov 30 2007
Externally publishedYes

Fingerprint

Fear
Motor Cortex
Basal Ganglia
Healthy Volunteers
Motor Activity
Magnetic Resonance Imaging

Keywords

  • amygdala
  • anxiety
  • basal ganglia
  • fMRI
  • freezing
  • motor cortex

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Butler, T., Pan, H., Tuescher, O., Engelien, A., Goldstein, M., Epstein, J., ... Silbersweig, D. A. (2007). Human fear-related motor neurocircuitry. Neuroscience, 150(1), 1-7. https://doi.org/10.1016/j.neuroscience.2007.09.048

Human fear-related motor neurocircuitry. / Butler, T.; Pan, H.; Tuescher, O.; Engelien, A.; Goldstein, M.; Epstein, J.; Weisholtz, D.; Root, J. C.; Protopopescu, X.; Cunningham-Bussel, A. C.; Chang, L.; Xie, Xianhong; Chen, Q.; Phelps, E. A.; Ledoux, J. E.; Stern, E.; Silbersweig, D. A.

In: Neuroscience, Vol. 150, No. 1, 30.11.2007, p. 1-7.

Research output: Contribution to journalArticle

Butler, T, Pan, H, Tuescher, O, Engelien, A, Goldstein, M, Epstein, J, Weisholtz, D, Root, JC, Protopopescu, X, Cunningham-Bussel, AC, Chang, L, Xie, X, Chen, Q, Phelps, EA, Ledoux, JE, Stern, E & Silbersweig, DA 2007, 'Human fear-related motor neurocircuitry', Neuroscience, vol. 150, no. 1, pp. 1-7. https://doi.org/10.1016/j.neuroscience.2007.09.048
Butler T, Pan H, Tuescher O, Engelien A, Goldstein M, Epstein J et al. Human fear-related motor neurocircuitry. Neuroscience. 2007 Nov 30;150(1):1-7. https://doi.org/10.1016/j.neuroscience.2007.09.048
Butler, T. ; Pan, H. ; Tuescher, O. ; Engelien, A. ; Goldstein, M. ; Epstein, J. ; Weisholtz, D. ; Root, J. C. ; Protopopescu, X. ; Cunningham-Bussel, A. C. ; Chang, L. ; Xie, Xianhong ; Chen, Q. ; Phelps, E. A. ; Ledoux, J. E. ; Stern, E. ; Silbersweig, D. A. / Human fear-related motor neurocircuitry. In: Neuroscience. 2007 ; Vol. 150, No. 1. pp. 1-7.
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