Human dorsal anterior cingulate cortex neurons mediate ongoing behavioural adaptation

Sameer A. Sheth, Matthew K. Mian, Shaun R. Patel, Wael F. Asaad, Ziv M. Williams, Darin D. Dougherty, George Bush, Emad N. Eskandar

Research output: Contribution to journalArticle

210 Citations (Scopus)

Abstract

The ability to optimize behavioural performance when confronted with continuously evolving environmental demands is a key element of human cognition. The dorsal anterior cingulate cortex (dACC), which lies on the medial surface of the frontal lobes, is important in regulating cognitive control. Hypotheses about its function include guiding reward-based decision making, monitoring for conflict between competing responses and predicting task difficulty. Precise mechanisms of dACC function remain unknown, however, because of the limited number of human neurophysiological studies. Here we use functional imaging and human single-neuron recordings to show that the firing of individual dACC neurons encodes current and recent cognitive load. We demonstrate that the modulation of current dACC activity by previous activity produces a behavioural adaptation that accelerates reactions to cues of similar difficulty to previous ones, and retards reactions to cues of different difficulty. Furthermore, this conflict adaptation, or Gratton effect, is abolished after surgically targeted ablation of the dACC. Our results demonstrate that the dACC provides a continuously updated prediction of expected cognitive demand to optimize future behavioural responses. In situations with stable cognitive demands, this signal promotes efficiency by hastening responses, but in situations with changing demands it engenders accuracy by delaying responses.

Original languageEnglish (US)
Pages (from-to)218-221
Number of pages4
JournalNature
Volume488
Issue number7410
DOIs
StatePublished - Aug 9 2012
Externally publishedYes

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Gyrus Cinguli
Neurons
Cues
Aptitude
Frontal Lobe
Reward
Cognition
Decision Making
Efficiency

ASJC Scopus subject areas

  • General

Cite this

Sheth, S. A., Mian, M. K., Patel, S. R., Asaad, W. F., Williams, Z. M., Dougherty, D. D., ... Eskandar, E. N. (2012). Human dorsal anterior cingulate cortex neurons mediate ongoing behavioural adaptation. Nature, 488(7410), 218-221. https://doi.org/10.1038/nature11239

Human dorsal anterior cingulate cortex neurons mediate ongoing behavioural adaptation. / Sheth, Sameer A.; Mian, Matthew K.; Patel, Shaun R.; Asaad, Wael F.; Williams, Ziv M.; Dougherty, Darin D.; Bush, George; Eskandar, Emad N.

In: Nature, Vol. 488, No. 7410, 09.08.2012, p. 218-221.

Research output: Contribution to journalArticle

Sheth, SA, Mian, MK, Patel, SR, Asaad, WF, Williams, ZM, Dougherty, DD, Bush, G & Eskandar, EN 2012, 'Human dorsal anterior cingulate cortex neurons mediate ongoing behavioural adaptation', Nature, vol. 488, no. 7410, pp. 218-221. https://doi.org/10.1038/nature11239
Sheth SA, Mian MK, Patel SR, Asaad WF, Williams ZM, Dougherty DD et al. Human dorsal anterior cingulate cortex neurons mediate ongoing behavioural adaptation. Nature. 2012 Aug 9;488(7410):218-221. https://doi.org/10.1038/nature11239
Sheth, Sameer A. ; Mian, Matthew K. ; Patel, Shaun R. ; Asaad, Wael F. ; Williams, Ziv M. ; Dougherty, Darin D. ; Bush, George ; Eskandar, Emad N. / Human dorsal anterior cingulate cortex neurons mediate ongoing behavioural adaptation. In: Nature. 2012 ; Vol. 488, No. 7410. pp. 218-221.
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