Human diseases associated with connexin mutations

Miduturu Srinivas, Vytas K. Verselis, Thomas W. White

Research output: Contribution to journalReview article

38 Scopus citations

Abstract

Gap junctions and hemichannels comprised of connexins impact many cellular processes. Significant advances in our understanding of the functional role of these channels have been made by the identification of a host of genetic diseases caused by connexin mutations. Prominent features of connexin disorders are the inability of other connexins expressed in the same cell type to compensate for the mutated one, and the ability of connexin mutants to dominantly influence the activity of other wild-type connexins. Functional studies have begun to identify some of the underlying mechanisms whereby connexin channel mutation contributes to the disease state. Detailed mechanistic understanding of these functional differences will help to facilitate new pathophysiology driven therapies for the diverse array of connexin genetic disorders. This article is part of a Special Issue entitled: Gap Junction Proteins edited by Jean Claude Herve.

Original languageEnglish (US)
Pages (from-to)192-201
Number of pages10
JournalBiochimica et Biophysica Acta - Biomembranes
Volume1860
Issue number1
DOIs
StatePublished - Jan 2018

Keywords

  • Connexin
  • Gap junction
  • Genetic disease
  • Hemichannel
  • Mutation

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Cell Biology

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