Human chorionic gonadotropin subunit measurement in primary hyperparathyroidism

J. L. Stock, B. D. Weintraub, S. W. Rosen, G. D. Aurbach, A. M. Spiegel, S. J. Marx

Research output: Contribution to journalArticle

29 Scopus citations

Abstract

The concentration of subunits of hCG (hCGα and hCGβ) was determined in plasma or serum from 70 patients with primary hyperparathyroidism (1°HPT). Two of three patients with parathyroid carcinoma showed elevation in plasma concentrations of both subunits, which fell after surgical removal of the tumor. An extract prepared from the tumor of 1 of these patients contained the subunits in high concentrations, whereas in extracts similarly prepared from tissues removed from 7 patients with benign 1°HPT, the subunits were not detectable or were present in much lower concentrations. In 42 cases of benign 1° HPT, samples from veins containing a 10-fold gradient of parathyroid hormone obtained during selective venous catheterization and peripheral samples from the same patients were analyzed for hCG subunits. Only 1 patient demonstrated a mild elevation of hCGα in parathyroid venous effluent alone that may have represented subunit release by apparently benign parathyroid tissue. Thirty patients with multiple endocrine neoplasia type I were tested; 8 evidenced clinically active islet cell tumors, and 6 of these 8 showed high circulating concentrations of hCGα (and hCGβ in 1 case). Patients in the multiple endocrine neoplasia type I group with 1°HPT or pituitary tumors, but no evident pancreatic islet disease, did not show elevations in subunit concentrations. Thus, in patients with 1°HPT, determination of subunits of hCG may be helpful in making the diagnosis of parathyroid carcinoma or in screening for associated (and probably malignant) pancreatic islet disease.

Original languageEnglish (US)
Pages (from-to)57-63
Number of pages7
JournalUnknown Journal
Volume54
Issue number1
DOIs
StatePublished - Jan 1 1982
Externally publishedYes

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

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  • Cite this

    Stock, J. L., Weintraub, B. D., Rosen, S. W., Aurbach, G. D., Spiegel, A. M., & Marx, S. J. (1982). Human chorionic gonadotropin subunit measurement in primary hyperparathyroidism. Unknown Journal, 54(1), 57-63. https://doi.org/10.1210/jcem-54-1-57