TY - JOUR
T1 - Human brain-derived acidic and basic fibroblast growth factors
T2 - Amino terminal sequences and specific mitogenic activities
AU - Gimenez-Gallego, Guillermo
AU - Conn, Greg
AU - Hatcher, Victor B.
AU - Thomas, Kenneth A.
PY - 1986/3/13
Y1 - 1986/3/13
N2 - Extended amino terminal sequence determinations, made on both acidic and basic fibroblast growth factors from human brain, showed extensive homology with each other and with their respective bovine counterparts. Both human growth factors in the presence of heparin have equivalent specific mitogenic activities on human umbilical vein endothelial cells in culture whereas in the absence of heparin, the acidic mitogen is less than 1% as active as the basic growth factor.
AB - Extended amino terminal sequence determinations, made on both acidic and basic fibroblast growth factors from human brain, showed extensive homology with each other and with their respective bovine counterparts. Both human growth factors in the presence of heparin have equivalent specific mitogenic activities on human umbilical vein endothelial cells in culture whereas in the absence of heparin, the acidic mitogen is less than 1% as active as the basic growth factor.
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U2 - 10.1016/0006-291X(86)90028-8
DO - 10.1016/0006-291X(86)90028-8
M3 - Article
C2 - 3964259
AN - SCOPUS:0022452713
SN - 0006-291X
VL - 135
SP - 541
EP - 548
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 2
ER -