Human brain-derived acidic and basic fibroblast growth factors: Amino terminal sequences and specific mitogenic activities

Guillermo Gimenez-Gallego, Greg Conn, Victor B. Hatcher, Kenneth A. Thomas

Research output: Contribution to journalArticle

89 Scopus citations

Abstract

Extended amino terminal sequence determinations, made on both acidic and basic fibroblast growth factors from human brain, showed extensive homology with each other and with their respective bovine counterparts. Both human growth factors in the presence of heparin have equivalent specific mitogenic activities on human umbilical vein endothelial cells in culture whereas in the absence of heparin, the acidic mitogen is less than 1% as active as the basic growth factor.

Original languageEnglish (US)
Pages (from-to)541-548
Number of pages8
JournalBiochemical and Biophysical Research Communications
Volume135
Issue number2
DOIs
StatePublished - Mar 13 1986

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

Fingerprint Dive into the research topics of 'Human brain-derived acidic and basic fibroblast growth factors: Amino terminal sequences and specific mitogenic activities'. Together they form a unique fingerprint.

  • Cite this