Human basal cell carcinoma is associated with Foxp3+ T cells in a Th2 dominant microenvironment

Helen G. Kaporis, Emma Guttman-Yassky, Michelle A. Lowes, Asifa S. Haider, Judilyn Fuentes-Duculan, Kamruz Darabi, Julia Whynot-Ertelt, Artemis Khatcherian, Irma Cardinale, Inna Novitskaya, James G. Krueger, John A. Carucci

Research output: Contribution to journalArticle

80 Citations (Scopus)

Abstract

Basal cell carcinoma (BCC), the most common human cancer, undergoes spontaneous regression in certain circumstances, which is potentially immune-mediated. To understand the immune response surrounding BCCs, we characterized the genomic, protein, and cellular microenvironment associated with BCC in comparison to normal skin. Our results demonstrated the following: (1) CD4+CD25+Foxp3+ surround epithelial tumor aggregates; (2) Immature dendritic cells (DCs) were abundant in the tumor microenvironment; (3) BCC showed increased expression of IL-4, IL-10, and CCL22 and increased expression of interferon-associated genes (IFI27, IRF1, IRF7, and G1P2) and IL-12/23, gene indicating a Th2 dominant microenvironment. Our findings suggest a dynamic state within the immune microenvironment associated with BCC. The finding of phenotypic T regs, in conjunction with immature DCs and Th2 cytokines, suggests an attenuated state of immunity to human BCC. In contrast, abundant CD8+ T cells, an interferon signal, and IL-12/23 suggest partial host antitumor response. A better understanding of these opposing forces within the immune microenvironment may facilitate development of more potent immune-based treatment for BCC and other human carcinomas.

Original languageEnglish (US)
Pages (from-to)2391-2398
Number of pages8
JournalJournal of Investigative Dermatology
Volume127
Issue number10
DOIs
StatePublished - Oct 2007
Externally publishedYes

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T-cells
Basal Cell Carcinoma
Interleukin-12
Interferons
Tumors
Genes
Cells
T-Lymphocytes
Interleukin-4
Interleukin-10
Interleukin-23
Skin
Cytokines
Dendritic Cells
Cellular Microenvironment
Proteins
Tumor Microenvironment
Immunity
Neoplasms
Carcinoma

ASJC Scopus subject areas

  • Dermatology
  • Medicine(all)

Cite this

Kaporis, H. G., Guttman-Yassky, E., Lowes, M. A., Haider, A. S., Fuentes-Duculan, J., Darabi, K., ... Carucci, J. A. (2007). Human basal cell carcinoma is associated with Foxp3+ T cells in a Th2 dominant microenvironment. Journal of Investigative Dermatology, 127(10), 2391-2398. https://doi.org/10.1038/sj.jid.5700884

Human basal cell carcinoma is associated with Foxp3+ T cells in a Th2 dominant microenvironment. / Kaporis, Helen G.; Guttman-Yassky, Emma; Lowes, Michelle A.; Haider, Asifa S.; Fuentes-Duculan, Judilyn; Darabi, Kamruz; Whynot-Ertelt, Julia; Khatcherian, Artemis; Cardinale, Irma; Novitskaya, Inna; Krueger, James G.; Carucci, John A.

In: Journal of Investigative Dermatology, Vol. 127, No. 10, 10.2007, p. 2391-2398.

Research output: Contribution to journalArticle

Kaporis, HG, Guttman-Yassky, E, Lowes, MA, Haider, AS, Fuentes-Duculan, J, Darabi, K, Whynot-Ertelt, J, Khatcherian, A, Cardinale, I, Novitskaya, I, Krueger, JG & Carucci, JA 2007, 'Human basal cell carcinoma is associated with Foxp3+ T cells in a Th2 dominant microenvironment', Journal of Investigative Dermatology, vol. 127, no. 10, pp. 2391-2398. https://doi.org/10.1038/sj.jid.5700884
Kaporis HG, Guttman-Yassky E, Lowes MA, Haider AS, Fuentes-Duculan J, Darabi K et al. Human basal cell carcinoma is associated with Foxp3+ T cells in a Th2 dominant microenvironment. Journal of Investigative Dermatology. 2007 Oct;127(10):2391-2398. https://doi.org/10.1038/sj.jid.5700884
Kaporis, Helen G. ; Guttman-Yassky, Emma ; Lowes, Michelle A. ; Haider, Asifa S. ; Fuentes-Duculan, Judilyn ; Darabi, Kamruz ; Whynot-Ertelt, Julia ; Khatcherian, Artemis ; Cardinale, Irma ; Novitskaya, Inna ; Krueger, James G. ; Carucci, John A. / Human basal cell carcinoma is associated with Foxp3+ T cells in a Th2 dominant microenvironment. In: Journal of Investigative Dermatology. 2007 ; Vol. 127, No. 10. pp. 2391-2398.
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