HTLV-1 infection in acute t- lymphocytic leukemia/lymphoma

Mohammad Barouqa; Morayma Reyes Gil; Radhika Sekhri; Mojisola Popoola; Juan Ding; Yanhua Wang

doi:10.4322/ACR.2021.307

HTLV-1 infection in acute t- lymphocytic leukemia/lymphoma

Mohammad Barouqa, Morayma Reyes Gil, Radhika Sekhri, Mojisola Popoola, Juan Ding, Yanhua Wang

Pathology

Research output: Contribution to journal › Article › peer-review

Abstract

Adult T- lymphocyte leukemia/ lymphoma (ATLL), described by Uchiyama et al. in 1977, is a distinct neoplasia of peripheral T-lymphocytes caused by human T-cell lymphotropic virus type 1 (HTLV-1). The authors describe the case of a 75-year-old female patient who presented with fever, chills, and altered mental status. The peripheral blood morphology showed large atypical lymphocytes with multilobed nuclei and flow cytometry consistent with ATLL. The authors discuss the pathophysiology, differential diagnosis, and subtypes of ATLL in addition to the diagnostic approach using flow cytometry when bone marrow biopsy is not available and modalities of treatment.

Original language	English (US)
Article number	e2021307
Journal	Autopsy and Case Reports
Volume	11
DOIs	https://doi.org/10.4322/ACR.2021.307
State	Published - 2021

Keywords

Adult T-Cell
Human T-lymphotropic virus 1
Leukemia
Leukemia-Lymphoma
Lymphoid

ASJC Scopus subject areas

Pathology and Forensic Medicine
Internal Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.4322/ACR.2021.307

Cite this

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title = "HTLV-1 infection in acute t- lymphocytic leukemia/lymphoma",

abstract = "Adult T- lymphocyte leukemia/ lymphoma (ATLL), described by Uchiyama et al. in 1977, is a distinct neoplasia of peripheral T-lymphocytes caused by human T-cell lymphotropic virus type 1 (HTLV-1). The authors describe the case of a 75-year-old female patient who presented with fever, chills, and altered mental status. The peripheral blood morphology showed large atypical lymphocytes with multilobed nuclei and flow cytometry consistent with ATLL. The authors discuss the pathophysiology, differential diagnosis, and subtypes of ATLL in addition to the diagnostic approach using flow cytometry when bone marrow biopsy is not available and modalities of treatment.",

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author = "Mohammad Barouqa and Gil, {Morayma Reyes} and Radhika Sekhri and Mojisola Popoola and Juan Ding and Yanhua Wang",

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year = "2021",

doi = "10.4322/ACR.2021.307",

language = "English (US)",

volume = "11",

journal = "Autopsy and Case Reports",

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T1 - HTLV-1 infection in acute t- lymphocytic leukemia/lymphoma

AU - Barouqa, Mohammad

AU - Gil, Morayma Reyes

AU - Sekhri, Radhika

AU - Popoola, Mojisola

AU - Ding, Juan

AU - Wang, Yanhua

PY - 2021

Y1 - 2021

N2 - Adult T- lymphocyte leukemia/ lymphoma (ATLL), described by Uchiyama et al. in 1977, is a distinct neoplasia of peripheral T-lymphocytes caused by human T-cell lymphotropic virus type 1 (HTLV-1). The authors describe the case of a 75-year-old female patient who presented with fever, chills, and altered mental status. The peripheral blood morphology showed large atypical lymphocytes with multilobed nuclei and flow cytometry consistent with ATLL. The authors discuss the pathophysiology, differential diagnosis, and subtypes of ATLL in addition to the diagnostic approach using flow cytometry when bone marrow biopsy is not available and modalities of treatment.

AB - Adult T- lymphocyte leukemia/ lymphoma (ATLL), described by Uchiyama et al. in 1977, is a distinct neoplasia of peripheral T-lymphocytes caused by human T-cell lymphotropic virus type 1 (HTLV-1). The authors describe the case of a 75-year-old female patient who presented with fever, chills, and altered mental status. The peripheral blood morphology showed large atypical lymphocytes with multilobed nuclei and flow cytometry consistent with ATLL. The authors discuss the pathophysiology, differential diagnosis, and subtypes of ATLL in addition to the diagnostic approach using flow cytometry when bone marrow biopsy is not available and modalities of treatment.

KW - Adult T-Cell

KW - Human T-lymphotropic virus 1

KW - Leukemia

KW - Leukemia-Lymphoma

KW - Lymphoid

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JF - Autopsy and Case Reports

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ER -

HTLV-1 infection in acute t- lymphocytic leukemia/lymphoma

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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