HPV 16 antibody prevalence in Jamaica and the United States reflects differences in cervical cancer rates

Howard Strickler, Gregory D. Kirk, J. Peter Figueroa, Elizabeth Ward, Alfred R. Braithwaite, Carlos Escoffery, James Drummond, Brad Goebel, David Waters, Roberta McClimens, Angela Manns

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Human papillomavirus (HPV) is widely accepted as the primary etiologic agent in the development of cervical cancer. DNA of a particular HPV type, HPV 16, is found in about half of tumors tested. Inconsistent with this causal relationship, however, population-based studies of HPV DNA prevalence have often failed to find high rates of anogenital HPV infection in countries with high cervical cancer rates. To examine this issue, we used serology to compare HPV 16 exposure in healthy volunteer blood donors in the United States (n = 278) and similar subjects from a country with 3-fold higher cervical cancer rates, Jamaica (n = 257). Jamaican sexually transmitted disease (STD) patients (n = 831) were also studied to examine in detail the relation of HPV 16 antibodies with sexual history. Serology was conducted using an ELISA employing HPV 16 virus-like particles (VLPs). Age-adjusted seroprevalence rates were greatest among male (29%) and female (42%) STD patients, intermediate in male (19%) and female (24%) Jamaican blood donors and lowest among male (3%) and female (12%) U.S. blood donors. The higher seroprevalence in women was significant, and prevalence tended to increase with age. In multivariate logistic regression, controlling for age and gender, Jamaican blood donors were 4.2-fold (95% CI 2.4-7.2) and STD patients 8.1-fold (95% CI 5.0-13.2) more likely to have HPV 16 VLP antibodies than U.S. blood donors. Among STD patients, HPV 16 antibodies were associated with lifetime number of sex partners and years of sexual activity, as well as other factors. Our data suggest that HPV 16 VLP antibodies are strongly associated with sexual behavior. Moreover, exposure to HPV 16 appears to be much greater in Jamaica than in the United States, consistent with the high rate of cervical cancer in Jamaica.

Original languageEnglish (US)
Pages (from-to)339-344
Number of pages6
JournalInternational Journal of Cancer
Volume80
Issue number3
DOIs
StatePublished - 1999
Externally publishedYes

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Jamaica
Human papillomavirus 16
Uterine Cervical Neoplasms
Papillomaviridae
Blood Donors
Antibodies
Sexually Transmitted Diseases
Virion
Seroepidemiologic Studies
Serology
Sexual Behavior
Papillomavirus Infections
DNA
Healthy Volunteers
Logistic Models
Enzyme-Linked Immunosorbent Assay

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

HPV 16 antibody prevalence in Jamaica and the United States reflects differences in cervical cancer rates. / Strickler, Howard; Kirk, Gregory D.; Figueroa, J. Peter; Ward, Elizabeth; Braithwaite, Alfred R.; Escoffery, Carlos; Drummond, James; Goebel, Brad; Waters, David; McClimens, Roberta; Manns, Angela.

In: International Journal of Cancer, Vol. 80, No. 3, 1999, p. 339-344.

Research output: Contribution to journalArticle

Strickler, H, Kirk, GD, Figueroa, JP, Ward, E, Braithwaite, AR, Escoffery, C, Drummond, J, Goebel, B, Waters, D, McClimens, R & Manns, A 1999, 'HPV 16 antibody prevalence in Jamaica and the United States reflects differences in cervical cancer rates', International Journal of Cancer, vol. 80, no. 3, pp. 339-344. https://doi.org/10.1002/(SICI)1097-0215(19990129)80:3<339::AID-IJC1>3.0.CO;2-F
Strickler, Howard ; Kirk, Gregory D. ; Figueroa, J. Peter ; Ward, Elizabeth ; Braithwaite, Alfred R. ; Escoffery, Carlos ; Drummond, James ; Goebel, Brad ; Waters, David ; McClimens, Roberta ; Manns, Angela. / HPV 16 antibody prevalence in Jamaica and the United States reflects differences in cervical cancer rates. In: International Journal of Cancer. 1999 ; Vol. 80, No. 3. pp. 339-344.
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abstract = "Human papillomavirus (HPV) is widely accepted as the primary etiologic agent in the development of cervical cancer. DNA of a particular HPV type, HPV 16, is found in about half of tumors tested. Inconsistent with this causal relationship, however, population-based studies of HPV DNA prevalence have often failed to find high rates of anogenital HPV infection in countries with high cervical cancer rates. To examine this issue, we used serology to compare HPV 16 exposure in healthy volunteer blood donors in the United States (n = 278) and similar subjects from a country with 3-fold higher cervical cancer rates, Jamaica (n = 257). Jamaican sexually transmitted disease (STD) patients (n = 831) were also studied to examine in detail the relation of HPV 16 antibodies with sexual history. Serology was conducted using an ELISA employing HPV 16 virus-like particles (VLPs). Age-adjusted seroprevalence rates were greatest among male (29{\%}) and female (42{\%}) STD patients, intermediate in male (19{\%}) and female (24{\%}) Jamaican blood donors and lowest among male (3{\%}) and female (12{\%}) U.S. blood donors. The higher seroprevalence in women was significant, and prevalence tended to increase with age. In multivariate logistic regression, controlling for age and gender, Jamaican blood donors were 4.2-fold (95{\%} CI 2.4-7.2) and STD patients 8.1-fold (95{\%} CI 5.0-13.2) more likely to have HPV 16 VLP antibodies than U.S. blood donors. Among STD patients, HPV 16 antibodies were associated with lifetime number of sex partners and years of sexual activity, as well as other factors. Our data suggest that HPV 16 VLP antibodies are strongly associated with sexual behavior. Moreover, exposure to HPV 16 appears to be much greater in Jamaica than in the United States, consistent with the high rate of cervical cancer in Jamaica.",
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AU - Kirk, Gregory D.

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AU - Escoffery, Carlos

AU - Drummond, James

AU - Goebel, Brad

AU - Waters, David

AU - McClimens, Roberta

AU - Manns, Angela

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