@article{f48f020f5ce04bc3b62fab0b60c7c56f,
title = "How we evaluate red blood cell compatibility and transfusion support for patients with sickle cell disease undergoing hematopoietic progenitor cell transplantation",
abstract = "Multiple hematopoietic progenitor cell (HPC) transplantation options for patients with sickle cell disease (SCD) are currently under investigation. Patients with SCD have a high rate of alloimmunization to red blood cell antigens, often complicating transfusion support. Transfusion reactions, including acute and delayed hemolytic reactions, have been observed despite immunosuppressive regimens. Allogeneic donor transplants have been shown to carry a risk of prolonged reticulocytopenia and acute hemolysis with severe anemia in nonmyeloablative regimens. We discuss our experience providing transfusion support to patients with SCD undergoing HPC transplantation, propose an outline for a complete pretransplantation evaluation, and discuss donor/recipient compatibility issues and their implications.",
author = "Allen, {Elizabeth S.} and Nelson, {Randin C.} and Flegel, {Willy A.}",
note = "Funding Information: This work was supported by the Intramural Research Program (project ID Z99 CL999999) of the NIH Clinical Center. Funding Information: We acknowledge Rebecca P. Coward, MT(ASCP)SBB (Department of Transfusion Medicine, NIH Clinical Center) for assistance evaluating patients and developing the consultation report template. We acknowledge Drs Matthew M. Hsieh, Courtney D. Fitzhugh, and John F. Tisdale (NHLBI) for developing the clinical trials NCT00061568, NCT00977691, NCT02105766, NCT03077542, and NCT02140554; caring for the patients during and after transplantation; and providing critical review of this manuscript. We acknowledge Dr Harvey G. Klein and Elizabeth J. Furlong (Department of Transfusion Medicine, NIH Clinical Center) for critical review of the manuscript.",
year = "2018",
month = nov,
doi = "10.1111/trf.14871",
language = "English (US)",
volume = "58",
pages = "2483--2489",
journal = "Transfusion",
issn = "0041-1132",
publisher = "Wiley-Blackwell",
number = "11",
}