How close are we to complete annotation of metabolomes?

Mark R. Viant, Irwin J. Kurland, Martin R. Jones, Warwick B. Dunn

Research output: Contribution to journalReview article

43 Citations (Scopus)

Abstract

The metabolome describes the full complement of the tens to hundreds of thousands of low molecular weight metabolites present within a biological system. Identification of the metabolome is critical for discovering the maximum amount of biochemical knowledge from metabolomics datasets. Yet no exhaustive experimental characterisation of any organismal metabolome has been reported to date, dramatically contrasting with the genome sequencing of thousands of plants, animals and microbes. Here, we review the status of metabolome annotation and describe advances in the analytical methodologies being applied. In part through new international coordination, we conclude that we are now entering a new era of metabolome annotation.

Original languageEnglish (US)
Pages (from-to)64-69
Number of pages6
JournalCurrent Opinion in Chemical Biology
Volume36
DOIs
StatePublished - Feb 1 2017

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Metabolome
Biological systems
Metabolites
Animals
Genes
Molecular weight
Metabolomics
Molecular Weight
Genome

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry

Cite this

How close are we to complete annotation of metabolomes? / Viant, Mark R.; Kurland, Irwin J.; Jones, Martin R.; Dunn, Warwick B.

In: Current Opinion in Chemical Biology, Vol. 36, 01.02.2017, p. 64-69.

Research output: Contribution to journalReview article

Viant, Mark R. ; Kurland, Irwin J. ; Jones, Martin R. ; Dunn, Warwick B. / How close are we to complete annotation of metabolomes?. In: Current Opinion in Chemical Biology. 2017 ; Vol. 36. pp. 64-69.
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