How a single protein complex accommodates many different H/ACA RNAs

Research output: Contribution to journalShort survey

41 Scopus citations

Abstract

More than 100 mammalian H/ACA RNAs form an equal number of ribonucleoproteins (RNPs) by associating with the same four core proteins. The function of these H/ACA RNPs is essential for biogenesis of the ribosome, splicing of precursor mRNAs (pre-mRNAs), maintenance of telomeres and probably for additional cellular processes. Recent crystal structures of archaeal H/ACA protein complexes show how the same four proteins accommodate >100 distinct but related H/ACA RNAs and reveal that a spatial mutation cluster underlies dyskeratosis congenita, a syndrome of bone marrow failure.

Original languageEnglish (US)
Pages (from-to)311-315
Number of pages5
JournalTrends in Biochemical Sciences
Volume31
Issue number6
DOIs
Publication statusPublished - Jun 1 2006

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ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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