TY - JOUR
T1 - Host dependent modulation of hepatitis delta virus replication in chronic delta hepatitis
AU - Gupta, Sanjeev
AU - Govindarajan, Sugantha
AU - Valinluck, Boontar
AU - Redeker, Allan G.
PY - 1991/12
Y1 - 1991/12
N2 - To determine whether host dependent differences modulated hepatitis delta virus replication in chronic delta hepatitis, we tested HDV RNA in homosexual and intravenous drug abuser populations. Overall, the seroprevalence of HDV RNA in the two groups with matching clinical characteristics was 72% (76/106 patient visits). A trend for greater prevalence of HDV RNA was noted at initial presentation in homosexuals (82%) compared to intravenous drug abusers (6O%, P < 0.05) and this trend appeared to be maintained during two years of sequential follow‐up. The seroprevalence of co‐appearing IgM and IgG anti‐HD antibodies was similar in the two groups of patients. However, in HDV RNA positive homosexuals IgG anti‐HD antibody was more prevalent, and additionally, assumed concordance with HDV RNA of 92% although the significance of this observation is unclear. The difference in prevalence of HIV in the two groups did not reach statistical significance. Prospective studies are required to confirm differences in HDV replication in various patient groups and to define underlying mechanisms.
AB - To determine whether host dependent differences modulated hepatitis delta virus replication in chronic delta hepatitis, we tested HDV RNA in homosexual and intravenous drug abuser populations. Overall, the seroprevalence of HDV RNA in the two groups with matching clinical characteristics was 72% (76/106 patient visits). A trend for greater prevalence of HDV RNA was noted at initial presentation in homosexuals (82%) compared to intravenous drug abusers (6O%, P < 0.05) and this trend appeared to be maintained during two years of sequential follow‐up. The seroprevalence of co‐appearing IgM and IgG anti‐HD antibodies was similar in the two groups of patients. However, in HDV RNA positive homosexuals IgG anti‐HD antibody was more prevalent, and additionally, assumed concordance with HDV RNA of 92% although the significance of this observation is unclear. The difference in prevalence of HIV in the two groups did not reach statistical significance. Prospective studies are required to confirm differences in HDV replication in various patient groups and to define underlying mechanisms.
KW - HDV RNA
KW - hepatitis
KW - homosexuals
KW - intravenous drug abusers
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U2 - 10.1002/jmv.1890350410
DO - 10.1002/jmv.1890350410
M3 - Article
C2 - 1802956
AN - SCOPUS:0025792017
SN - 0146-6615
VL - 35
SP - 259
EP - 262
JO - Journal of Medical Virology
JF - Journal of Medical Virology
IS - 4
ER -