Host defenses in experimental scrub typhus: Mapping the gene that controls natural resistance in mice

M. G. Groves, D. L. Rosenstreich, B. A. Taylor, J. V. Osterman

Research output: Contribution to journalArticle

47 Scopus citations

Abstract

Natural resistance of mice to lethal infections of Rickettsia tsutsugamushi, strain Gilliam, is controlled by a single, autosomal, dominant gene, which we have designated Ric, with r and s representing the resistant and susceptible alleles, respectively. Using three sets of recombinant inbred mouse strains (BXD, BXH, and BXJ), the Ric locus was mapped to Chromosome 5 closely linked to the retinal degeneration (rd) locus. This linkage was confirmed by a backcross analysis. Based on the RI strains and the C57BL/6Ty-le congenic strain (the only proven Ric-rd cross-over), we estimate the recombination frequency between Ric and rd to be 0.015. Three presumptive Ric-rd recombinants detected among 93 backcross mice may represent cases of incomplete penetrance of the resistance allele rather than recombination. Analysis of the C57BL/6JTy-le congenic strain indicates that Ric is proximal to rd on Chromosome 5. If so, the correct gene order is Pgm-1-W-Ric-rd-Gus.

Original languageEnglish (US)
Pages (from-to)1395-1399
Number of pages5
JournalJournal of Immunology
Volume125
Issue number3
StatePublished - Jan 1 1980
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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