Abstract
The respiratory epithelium provides both a physical and an immunological barrier to inhaled pathogens. In the normal host, innate defences prevent bacteria from activating inflammation by providing efficient muco-ciliary clearance and antimicrobial activity. Bacteria that persist in the airway lumen, as in cystic fibrosis, activate both the professional immune cells in the respiratory mucosa as well as the more abundant airway epithelial cells. As most of the bacteria become entrapped in airway mucin, shed bacterial products such as pili, flagella, peptidoglycan and lipopolysaccharide from lysed bacteria are likely to be the stimuli most important in activating epithelial signalling. The airway cells respond briskly to bacterial components through several signalling systems which activate epithelial expression of pro-inflammatory cytokines and chemokines. These signals recruit neutrophils to the airways where they eliminate the contaminating bacteria causing inflammation and the ensuing clinical signs of infection.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 245-252 |
| Number of pages | 8 |
| Journal | Paediatric Respiratory Reviews |
| Volume | 2 |
| Issue number | 3 |
| DOIs | |
| State | Published - 2001 |
| Externally published | Yes |
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Keywords
- Cystic fibrosis
- Inflammation
- P. aeruginosa
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
- Pulmonary and Respiratory Medicine
Cite this
Host-bacterial interactions in the initiation of inflammation. / Rastogi, Deepa; Ratner, A. J.; Prince, A.
In: Paediatric Respiratory Reviews, Vol. 2, No. 3, 2001, p. 245-252.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Host-bacterial interactions in the initiation of inflammation
AU - Rastogi, Deepa
AU - Ratner, A. J.
AU - Prince, A.
PY - 2001
Y1 - 2001
N2 - The respiratory epithelium provides both a physical and an immunological barrier to inhaled pathogens. In the normal host, innate defences prevent bacteria from activating inflammation by providing efficient muco-ciliary clearance and antimicrobial activity. Bacteria that persist in the airway lumen, as in cystic fibrosis, activate both the professional immune cells in the respiratory mucosa as well as the more abundant airway epithelial cells. As most of the bacteria become entrapped in airway mucin, shed bacterial products such as pili, flagella, peptidoglycan and lipopolysaccharide from lysed bacteria are likely to be the stimuli most important in activating epithelial signalling. The airway cells respond briskly to bacterial components through several signalling systems which activate epithelial expression of pro-inflammatory cytokines and chemokines. These signals recruit neutrophils to the airways where they eliminate the contaminating bacteria causing inflammation and the ensuing clinical signs of infection.
AB - The respiratory epithelium provides both a physical and an immunological barrier to inhaled pathogens. In the normal host, innate defences prevent bacteria from activating inflammation by providing efficient muco-ciliary clearance and antimicrobial activity. Bacteria that persist in the airway lumen, as in cystic fibrosis, activate both the professional immune cells in the respiratory mucosa as well as the more abundant airway epithelial cells. As most of the bacteria become entrapped in airway mucin, shed bacterial products such as pili, flagella, peptidoglycan and lipopolysaccharide from lysed bacteria are likely to be the stimuli most important in activating epithelial signalling. The airway cells respond briskly to bacterial components through several signalling systems which activate epithelial expression of pro-inflammatory cytokines and chemokines. These signals recruit neutrophils to the airways where they eliminate the contaminating bacteria causing inflammation and the ensuing clinical signs of infection.
KW - Cystic fibrosis
KW - Inflammation
KW - P. aeruginosa
UR - http://www.scopus.com/inward/record.url?scp=0035736038&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0035736038&partnerID=8YFLogxK
U2 - 10.1053/prrv.2001.0147
DO - 10.1053/prrv.2001.0147
M3 - Article
C2 - 12052326
AN - SCOPUS:0035736038
VL - 2
SP - 245
EP - 252
JO - Paediatric Respiratory Reviews
JF - Paediatric Respiratory Reviews
SN - 1526-0550
IS - 3
ER -