Hormone-sensitive adenylate cyclase in glomerular cells. Possible role for inflammatory diseases of the glomerulus

Elisabeth M. Paietta, J. D. Schwarzmeier, G. Simbruner, U. Latzka, G. Lubec

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Using the adenylate cyclase assay after Ross the authors examined hormone sensitivity of isolated glomerular cells. cAMP production was increased 1.3-1.6-fold by stimulation with isoproterenol, 1.5-1.8 times by prostaglandin E 1 and 1.4-1.5 times by histamine. The isoproterenol reaction could be completely inhibited by propranolol, the histamine effect was abolished by the H2-blocking agent cimetidine. As a control the authors applied sodium fluoride, which directly activates the catalytic adenylate cyclase unit, increasing the activity 1.8-2.7 times (depending on the method of homogenization). These findings could reflect some physiological or pathophysiological implications, which are discussed.

Original languageEnglish (US)
Pages (from-to)74-78
Number of pages5
JournalRenal Physiology
Volume4
Issue number2-3
StatePublished - 1981
Externally publishedYes

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Isoproterenol
Adenylyl Cyclases
Histamine Agents
Hormones
Sodium Fluoride
Cimetidine
Prostaglandins E
Propranolol
Histamine

ASJC Scopus subject areas

  • Physiology
  • Nephrology

Cite this

Hormone-sensitive adenylate cyclase in glomerular cells. Possible role for inflammatory diseases of the glomerulus. / Paietta, Elisabeth M.; Schwarzmeier, J. D.; Simbruner, G.; Latzka, U.; Lubec, G.

In: Renal Physiology, Vol. 4, No. 2-3, 1981, p. 74-78.

Research output: Contribution to journalArticle

Paietta, EM, Schwarzmeier, JD, Simbruner, G, Latzka, U & Lubec, G 1981, 'Hormone-sensitive adenylate cyclase in glomerular cells. Possible role for inflammatory diseases of the glomerulus', Renal Physiology, vol. 4, no. 2-3, pp. 74-78.
Paietta, Elisabeth M. ; Schwarzmeier, J. D. ; Simbruner, G. ; Latzka, U. ; Lubec, G. / Hormone-sensitive adenylate cyclase in glomerular cells. Possible role for inflammatory diseases of the glomerulus. In: Renal Physiology. 1981 ; Vol. 4, No. 2-3. pp. 74-78.
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