Honeycomb-like tubular structure in axoplasm

Asao Hirano, Robert Rubin, Carl H. Sutton, H. M. Zimmerman

Research output: Contribution to journalArticle

15 Scopus citations


A honeycomb-like tubular array was observed in heavily myelinated axons. It was observed in the cerebellum of an apparently normal rat and a chimpanzee with "Kurulike" symptoms. It was also found in the cerebral cortex of a mouse that had had a intracerebral tumor implant. A common underlying etiology could not be found. It is suggested, however, that this structure represents a specific axonal response to perhaps a variety of as yet unknown conditions.

Original languageEnglish (US)
Pages (from-to)17-25
Number of pages9
JournalActa Neuropathologica
Issue number1
Publication statusPublished - Mar 1 1968



  • Axonal reactive changes
  • Axoplasm
  • Electron microscopy
  • Myelinated CNS axons
  • Tubular structures

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Clinical Neurology
  • Cellular and Molecular Neuroscience

Cite this

Hirano, A., Rubin, R., Sutton, C. H., & Zimmerman, H. M. (1968). Honeycomb-like tubular structure in axoplasm. Acta Neuropathologica, 10(1), 17-25. https://doi.org/10.1007/BF00690506