HLA-DRB1 and DQB typing of Hispanic American patients with rheumatoid arthritis

The 'shared epitope' hypothesis may not apply

Katerina Teller, Lalbachan Budhai, Meilin Zhang, Nogah Haramati, Harold D. Keiser, Anne Davidson

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

Objective. To determine whether the association of particular MHC class II alleles and the DRB1 'shared epitope' with disease susceptibility and severity in rheumatoid arthritis (RA) applies to ethnic groups other than Caucasian Americans. Methods. 67 Hispanic American patients with RA and a similar number of ethnically matched controls were typed for DRB1 using polymerase chain reaction methods. DR4 subtype and DQB1 type were determined for the subjects positive for DR4. Disease severity in the patients with RA was assessed by clinical, radiographic and laboratory variables. Results. The frequency of DR4 was significantly increased in the subjects with RA compared to the control group. However, the 'shared' DRB1 amino acid sequence was relatively infrequent in the Hispanic American patients with RA, and there was no association of specific DR4 or DQ alleles with more severe disease or extraarticular manifestations. Conclusion. The HLA markers that predict poor prognosis and suggest that more agressive clinical management may be appropriate in Caucasian American patients with RA may not be useful in other ethnic groups.

Original languageEnglish (US)
Pages (from-to)1363-1368
Number of pages6
JournalJournal of Rheumatology
Volume23
Issue number8
StatePublished - 1996

Fingerprint

HLA-DRB1 Chains
Hispanic Americans
Epitopes
Rheumatoid Arthritis
Ethnic Groups
Alleles
Disease Susceptibility
HLA-DQbeta antigen
Amino Acid Sequence
Polymerase Chain Reaction
Control Groups

Keywords

  • MHC class II
  • Minorities
  • Rheumatoid arthritis

ASJC Scopus subject areas

  • Rheumatology
  • Immunology

Cite this

HLA-DRB1 and DQB typing of Hispanic American patients with rheumatoid arthritis : The 'shared epitope' hypothesis may not apply. / Teller, Katerina; Budhai, Lalbachan; Zhang, Meilin; Haramati, Nogah; Keiser, Harold D.; Davidson, Anne.

In: Journal of Rheumatology, Vol. 23, No. 8, 1996, p. 1363-1368.

Research output: Contribution to journalArticle

Teller, Katerina ; Budhai, Lalbachan ; Zhang, Meilin ; Haramati, Nogah ; Keiser, Harold D. ; Davidson, Anne. / HLA-DRB1 and DQB typing of Hispanic American patients with rheumatoid arthritis : The 'shared epitope' hypothesis may not apply. In: Journal of Rheumatology. 1996 ; Vol. 23, No. 8. pp. 1363-1368.
@article{73646b9eabe34c2abaa893a29ba4d8ad,
title = "HLA-DRB1 and DQB typing of Hispanic American patients with rheumatoid arthritis: The 'shared epitope' hypothesis may not apply",
abstract = "Objective. To determine whether the association of particular MHC class II alleles and the DRB1 'shared epitope' with disease susceptibility and severity in rheumatoid arthritis (RA) applies to ethnic groups other than Caucasian Americans. Methods. 67 Hispanic American patients with RA and a similar number of ethnically matched controls were typed for DRB1 using polymerase chain reaction methods. DR4 subtype and DQB1 type were determined for the subjects positive for DR4. Disease severity in the patients with RA was assessed by clinical, radiographic and laboratory variables. Results. The frequency of DR4 was significantly increased in the subjects with RA compared to the control group. However, the 'shared' DRB1 amino acid sequence was relatively infrequent in the Hispanic American patients with RA, and there was no association of specific DR4 or DQ alleles with more severe disease or extraarticular manifestations. Conclusion. The HLA markers that predict poor prognosis and suggest that more agressive clinical management may be appropriate in Caucasian American patients with RA may not be useful in other ethnic groups.",
keywords = "MHC class II, Minorities, Rheumatoid arthritis",
author = "Katerina Teller and Lalbachan Budhai and Meilin Zhang and Nogah Haramati and Keiser, {Harold D.} and Anne Davidson",
year = "1996",
language = "English (US)",
volume = "23",
pages = "1363--1368",
journal = "Journal of Rheumatology",
issn = "0315-162X",
publisher = "Journal of Rheumatology",
number = "8",

}

TY - JOUR

T1 - HLA-DRB1 and DQB typing of Hispanic American patients with rheumatoid arthritis

T2 - The 'shared epitope' hypothesis may not apply

AU - Teller, Katerina

AU - Budhai, Lalbachan

AU - Zhang, Meilin

AU - Haramati, Nogah

AU - Keiser, Harold D.

AU - Davidson, Anne

PY - 1996

Y1 - 1996

N2 - Objective. To determine whether the association of particular MHC class II alleles and the DRB1 'shared epitope' with disease susceptibility and severity in rheumatoid arthritis (RA) applies to ethnic groups other than Caucasian Americans. Methods. 67 Hispanic American patients with RA and a similar number of ethnically matched controls were typed for DRB1 using polymerase chain reaction methods. DR4 subtype and DQB1 type were determined for the subjects positive for DR4. Disease severity in the patients with RA was assessed by clinical, radiographic and laboratory variables. Results. The frequency of DR4 was significantly increased in the subjects with RA compared to the control group. However, the 'shared' DRB1 amino acid sequence was relatively infrequent in the Hispanic American patients with RA, and there was no association of specific DR4 or DQ alleles with more severe disease or extraarticular manifestations. Conclusion. The HLA markers that predict poor prognosis and suggest that more agressive clinical management may be appropriate in Caucasian American patients with RA may not be useful in other ethnic groups.

AB - Objective. To determine whether the association of particular MHC class II alleles and the DRB1 'shared epitope' with disease susceptibility and severity in rheumatoid arthritis (RA) applies to ethnic groups other than Caucasian Americans. Methods. 67 Hispanic American patients with RA and a similar number of ethnically matched controls were typed for DRB1 using polymerase chain reaction methods. DR4 subtype and DQB1 type were determined for the subjects positive for DR4. Disease severity in the patients with RA was assessed by clinical, radiographic and laboratory variables. Results. The frequency of DR4 was significantly increased in the subjects with RA compared to the control group. However, the 'shared' DRB1 amino acid sequence was relatively infrequent in the Hispanic American patients with RA, and there was no association of specific DR4 or DQ alleles with more severe disease or extraarticular manifestations. Conclusion. The HLA markers that predict poor prognosis and suggest that more agressive clinical management may be appropriate in Caucasian American patients with RA may not be useful in other ethnic groups.

KW - MHC class II

KW - Minorities

KW - Rheumatoid arthritis

UR - http://www.scopus.com/inward/record.url?scp=0029781943&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029781943&partnerID=8YFLogxK

M3 - Article

VL - 23

SP - 1363

EP - 1368

JO - Journal of Rheumatology

JF - Journal of Rheumatology

SN - 0315-162X

IS - 8

ER -