HLA class I supertypes in type 1 diabetic children in an urban children's hospital

Zoltan Antal, Irene Jarchum, Teresa P. DiLorenzo

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Scopus citations

Abstract

Type 1 diabetes is an autoimmune disorder characterized by progressive destruction of insulin-secreting β cells of the pancreas, in which CD8 + T cells play a critical role. The diversity in the HLA alleles expressed among various racial and ethnic groups leads to great variability in antigen presentation and recognition by CD8+ T cells in the context of MHC class I molecules. To date, studies aimed at identifying disease-relevant antigenic epitopes have focused on using mice transgenic for HLA-A*0201, a common allele, particularly among Caucasians. We present HLA class I typing data from 88 children with type 1 diabetes at the Children's Hospital at Montefiore, where the patient population is ethnically diverse, but largely minority. When categorized into the HLA supertypes A2, A3, B7, and C1, 77% of those studied have alleles belonging to at least one supertype, and of these patients, 65% do not belong to the A2 supertype, which is the supertype represented by the HLA-A*0201 allele. These results support the need for studies using HLA transgenic mice expressing MHC molecules representative of a variety of HLA supertypes, particularly when searching for antigenic epitopes applicable for study among largely urban, minority pediatric populations.

Original languageEnglish (US)
Title of host publicationImmunology of Diabetes V From Bench to Bedside
PublisherBlackwell Publishing Inc.
Pages86-89
Number of pages4
ISBN (Print)9781573317337
DOIs
StatePublished - Dec 2008

Publication series

NameAnnals of the New York Academy of Sciences
Volume1150
ISSN (Print)0077-8923
ISSN (Electronic)1749-6632

Keywords

  • Human leukocyte antigen (HLA)
  • Transgenic mice
  • Type 1 diabetes

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

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    Antal, Z., Jarchum, I., & DiLorenzo, T. P. (2008). HLA class I supertypes in type 1 diabetic children in an urban children's hospital. In Immunology of Diabetes V From Bench to Bedside (pp. 86-89). (Annals of the New York Academy of Sciences; Vol. 1150). Blackwell Publishing Inc.. https://doi.org/10.1196/annals.1447.005