HLA class I supertypes in type 1 diabetic children in an urban children's hospital

Zoltan Antal, Irene Jarchum, Teresa P. DiLorenzo

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)

Abstract

Type 1 diabetes is an autoimmune disorder characterized by progressive destruction of insulin-secreting β cells of the pancreas, in which CD8 + T cells play a critical role. The diversity in the HLA alleles expressed among various racial and ethnic groups leads to great variability in antigen presentation and recognition by CD8+ T cells in the context of MHC class I molecules. To date, studies aimed at identifying disease-relevant antigenic epitopes have focused on using mice transgenic for HLA-A*0201, a common allele, particularly among Caucasians. We present HLA class I typing data from 88 children with type 1 diabetes at the Children's Hospital at Montefiore, where the patient population is ethnically diverse, but largely minority. When categorized into the HLA supertypes A2, A3, B7, and C1, 77% of those studied have alleles belonging to at least one supertype, and of these patients, 65% do not belong to the A2 supertype, which is the supertype represented by the HLA-A*0201 allele. These results support the need for studies using HLA transgenic mice expressing MHC molecules representative of a variety of HLA supertypes, particularly when searching for antigenic epitopes applicable for study among largely urban, minority pediatric populations.

Original languageEnglish (US)
Title of host publicationAnnals of the New York Academy of Sciences
Pages86-89
Number of pages4
Volume1150
DOIs
StatePublished - Dec 2008

Publication series

NameAnnals of the New York Academy of Sciences
Volume1150
ISSN (Print)00778923
ISSN (Electronic)17496632

Fingerprint

T-cells
Urban Hospitals
Medical problems
Epitopes
Alleles
HLA-A2 Antigen
Pediatrics
Molecules
Type 1 Diabetes Mellitus
Transgenic Mice
Insulin
T-Lymphocytes
Antigens
Antigen Presentation
Insulin-Secreting Cells
Ethnic Groups
varespladib methyl
Population
Pancreas
HLA-A*02:01 antigen

Keywords

  • Human leukocyte antigen (HLA)
  • Transgenic mice
  • Type 1 diabetes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Antal, Z., Jarchum, I., & DiLorenzo, T. P. (2008). HLA class I supertypes in type 1 diabetic children in an urban children's hospital. In Annals of the New York Academy of Sciences (Vol. 1150, pp. 86-89). (Annals of the New York Academy of Sciences; Vol. 1150). https://doi.org/10.1196/annals.1447.005

HLA class I supertypes in type 1 diabetic children in an urban children's hospital. / Antal, Zoltan; Jarchum, Irene; DiLorenzo, Teresa P.

Annals of the New York Academy of Sciences. Vol. 1150 2008. p. 86-89 (Annals of the New York Academy of Sciences; Vol. 1150).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Antal, Z, Jarchum, I & DiLorenzo, TP 2008, HLA class I supertypes in type 1 diabetic children in an urban children's hospital. in Annals of the New York Academy of Sciences. vol. 1150, Annals of the New York Academy of Sciences, vol. 1150, pp. 86-89. https://doi.org/10.1196/annals.1447.005
Antal Z, Jarchum I, DiLorenzo TP. HLA class I supertypes in type 1 diabetic children in an urban children's hospital. In Annals of the New York Academy of Sciences. Vol. 1150. 2008. p. 86-89. (Annals of the New York Academy of Sciences). https://doi.org/10.1196/annals.1447.005
Antal, Zoltan ; Jarchum, Irene ; DiLorenzo, Teresa P. / HLA class I supertypes in type 1 diabetic children in an urban children's hospital. Annals of the New York Academy of Sciences. Vol. 1150 2008. pp. 86-89 (Annals of the New York Academy of Sciences).
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