HLA class I and II alleles are associated with microvascular complications of type 1 diabetes

E. M. Lipner, Yaron Tomer, J. A. Noble, M. C. Monti, J. T. Lonsdale, B. Corso, W. C L Stewart, D. A. Greenberg

Research output: Contribution to journalArticle

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Abstract

Although HLA alleles are associated with type 1 diabetes, association with microvascular complications remains controversial. We tested HLA association with complications in multiplex type 1 diabetes families.Probands from 425 type 1 diabetes families from the Human Biological Data Interchange (HBDI) collection were analyzed. The frequencies of specific HLA alleles in patients with complications were compared with the frequencies in complications-free patients. The complications we examined were: retinopathy, neuropathy, and nephropathy. We used logistic regression models with covariates to estimate odds ratios.We found that the DRB1*03:01 allele is a protective factor for complications (OR. =. 0.58; p=. 0.03), as is the DQA1*05:01-DQB1*02:01 haplotype found in linkage disequilibrium with DRB1*03:01 (OR. =. 0.59; p=. 0.031). The DRB1*04:01 allele showed no evidence of association (OR. =. 1.13; p=. 0.624), although DRB1*04:01 showed suggestive evidence when the carriers of the protective DRB1*03:01 were removed from the analysis. The class II DQA1*03:01-DQB1*03:02 haplotype was not associated with complications, but the class I allele B*39:06 (OR. =. 3.27; p=. 0.008) suggested a strong positive association with complications.Our results show that in type 1 diabetes patients, specific HLA alleles may be involved in susceptibility to, or protection from, microvascular complications.

Original languageEnglish (US)
Pages (from-to)538-544
Number of pages7
JournalHuman Immunology
Volume74
Issue number5
DOIs
StatePublished - May 2013

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Type 1 Diabetes Mellitus
Alleles
Haplotypes
Logistic Models
Linkage Disequilibrium
Odds Ratio

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Lipner, E. M., Tomer, Y., Noble, J. A., Monti, M. C., Lonsdale, J. T., Corso, B., ... Greenberg, D. A. (2013). HLA class I and II alleles are associated with microvascular complications of type 1 diabetes. Human Immunology, 74(5), 538-544. https://doi.org/10.1016/j.humimm.2013.01.013

HLA class I and II alleles are associated with microvascular complications of type 1 diabetes. / Lipner, E. M.; Tomer, Yaron; Noble, J. A.; Monti, M. C.; Lonsdale, J. T.; Corso, B.; Stewart, W. C L; Greenberg, D. A.

In: Human Immunology, Vol. 74, No. 5, 05.2013, p. 538-544.

Research output: Contribution to journalArticle

Lipner, EM, Tomer, Y, Noble, JA, Monti, MC, Lonsdale, JT, Corso, B, Stewart, WCL & Greenberg, DA 2013, 'HLA class I and II alleles are associated with microvascular complications of type 1 diabetes', Human Immunology, vol. 74, no. 5, pp. 538-544. https://doi.org/10.1016/j.humimm.2013.01.013
Lipner, E. M. ; Tomer, Yaron ; Noble, J. A. ; Monti, M. C. ; Lonsdale, J. T. ; Corso, B. ; Stewart, W. C L ; Greenberg, D. A. / HLA class I and II alleles are associated with microvascular complications of type 1 diabetes. In: Human Immunology. 2013 ; Vol. 74, No. 5. pp. 538-544.
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