HLA-B07, HLA-DRB107, HLA-DRB112, and HLA-c03:02 strongly associate with BMI: Data from 1.3 million healthy Chinese adults

Jie Shen, Tingwei Guo, Tao Wang, Yisong Zhen, Xiao Ma, Yuan Wang, Zhi Xin Zhang, Jian Ping Cai, Wei Mao, Fa Ming Zhu, Jian Ping Li, Zhen Lei Wang, De Mei Zhang, Meng Li Liu, Xiao Yan Shan, Bo Wei Zhang, Chuan Fu Zhu, Zhi Hui Deng, Wei Jian Yu, Qiang ChenGuo Liang Li, Tao Yang, Shan Lu, Qin Qin Pan, Su Fan, Xiao Yan Wang, Xing Zhao, Xin Yun Bi, Yan Hui Qiao, Pin Can Su, Rong Lv, Guo Ying Li, Heng Cong Li, Bin Pei, Li Xin Jiao, Gang Shen, Jie Liu, Zhi Hui Feng, Yu Ping Su, Yu Bin Xie, Wen Ying Di, Xin Yu Wang, Xiang Liu, Xiao Ping Zhang, Dan Du, Qi Liu, Ying Han, Jia Wei Chen, Min Gu, Leslie J. Baier

Research output: Contribution to journalArticle

Abstract

Strong associations between HLA alleles and infectious and autoimmune diseases are well established. Although obesity is also associated with these diseases, the relationship between HLA and obesity has not been systematically investigated in a large cohort. In the current study, we analyzed the association of HLA alleles with BMI using data from 1.3 million healthy adult donors from the Chinese Marrow Donor Program (CMDP). We found 23 HLA alleles, including 12 low-resolution and 11 highresolution alleles, were significantly associated with BMI after correction for multiple testing. Alleles associated with high BMI were enriched in haplotypes that were common in both Chinese and European populations, whereas the alleles associated with low BMI were enriched in haplotypes common only in Asians. Alleles B07, DRB107, DRB112, and C03:02 provided the strongest associations with BMI (P = 6.89 × 10-10, 1.32 × 10-9, 1.52 × 10-9, and 4.45 × 10-8, respectively), where B07 and DRB107 also had evidence for sex-specific effects (Pheterogeneity = 0.0067 and 0.00058, respectively). These results, which identify associations between alleles of HLA-B, DRB1, and C with BMI in Chinese young adults, implicate a novelbiological connection between HLA alleles and obesity.

Original languageEnglish (US)
Pages (from-to)861-871
Number of pages11
JournalDiabetes
Volume67
Issue number5
DOIs
StatePublished - May 1 2018

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ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Shen, J., Guo, T., Wang, T., Zhen, Y., Ma, X., Wang, Y., Zhang, Z. X., Cai, J. P., Mao, W., Zhu, F. M., Li, J. P., Wang, Z. L., Zhang, D. M., Liu, M. L., Shan, X. Y., Zhang, B. W., Zhu, C. F., Deng, Z. H., Yu, W. J., ... Baier, L. J. (2018). HLA-B07, HLA-DRB107, HLA-DRB112, and HLA-c03:02 strongly associate with BMI: Data from 1.3 million healthy Chinese adults. Diabetes, 67(5), 861-871. https://doi.org/10.2337/db17-0852