@article{72ac7bb9a67a4b618d23be0f866fbae5,
title = "HLA-B∗07, HLA-DRB1∗07, HLA-DRB1∗12, and HLA-c∗03:02 strongly associate with BMI: Data from 1.3 million healthy Chinese adults",
abstract = "Strong associations between HLA alleles and infectious and autoimmune diseases are well established. Although obesity is also associated with these diseases, the relationship between HLA and obesity has not been systematically investigated in a large cohort. In the current study, we analyzed the association of HLA alleles with BMI using data from 1.3 million healthy adult donors from the Chinese Marrow Donor Program (CMDP). We found 23 HLA alleles, including 12 low-resolution and 11 highresolution alleles, were significantly associated with BMI after correction for multiple testing. Alleles associated with high BMI were enriched in haplotypes that were common in both Chinese and European populations, whereas the alleles associated with low BMI were enriched in haplotypes common only in Asians. Alleles B∗07, DRB1∗07, DRB1∗12, and C∗03:02 provided the strongest associations with BMI (P = 6.89 × 10-10, 1.32 × 10-9, 1.52 × 10-9, and 4.45 × 10-8, respectively), where B∗07 and DRB1∗07 also had evidence for sex-specific effects (Pheterogeneity = 0.0067 and 0.00058, respectively). These results, which identify associations between alleles of HLA-B, DRB1, and C with BMI in Chinese young adults, implicate a novelbiological connection between HLA alleles and obesity.",
author = "Jie Shen and Tingwei Guo and Tao Wang and Yisong Zhen and Xiao Ma and Yuan Wang and Zhang, {Zhi Xin} and Cai, {Jian Ping} and Wei Mao and Zhu, {Fa Ming} and Li, {Jian Ping} and Wang, {Zhen Lei} and Zhang, {De Mei} and Liu, {Meng Li} and Shan, {Xiao Yan} and Zhang, {Bo Wei} and Zhu, {Chuan Fu} and Deng, {Zhi Hui} and Yu, {Wei Jian} and Qiang Chen and Li, {Guo Liang} and Tao Yang and Shan Lu and Pan, {Qin Qin} and Su Fan and Wang, {Xiao Yan} and Xing Zhao and Bi, {Xin Yun} and Qiao, {Yan Hui} and Su, {Pin Can} and Rong Lv and Li, {Guo Ying} and Li, {Heng Cong} and Bin Pei and Jiao, {Li Xin} and Gang Shen and Jie Liu and Feng, {Zhi Hui} and Su, {Yu Ping} and Xie, {Yu Bin} and Di, {Wen Ying} and Wang, {Xin Yu} and Xiang Liu and Zhang, {Xiao Ping} and Dan Du and Qi Liu and Ying Han and Chen, {Jia Wei} and Min Gu and Baier, {Leslie J.}",
note = "Funding Information: Acknowledgments. The authors thank Dr. Bernice Morrow, Department of Genetics, Albert Einstein College of Medicine, and Dr. Enpeng Zhao, Department of Medicine, Albert Einstein College of Medicine, for critical comments and suggestions for discussion. All of the data are from the CMDP. Funding. This work was supported by grants from the CMDP (Grant No. 2011001), the Jiangsu Province Administration of Traditional Chinese Medicine (Grant No. LZ1320), and the Foundation of Jiangsu Health Committee and the State Key Laboratory of Natural Medicines of China Pharmaceutical University (Grant No. SKLNMZZ 20210F). Duality of Interest. No potential conflicts of interest relevant to this article were reported. Author Contributions. J.S. and T.G. conceived the study and contributed to the study design and analysis strategy. J.S., T.G., T.W., Y.Z., and Y.W. conducted all analyses. J.S., T.G., and L.J.B. wrote the manuscript. X.M., Z.-X.Z., J.-P.C., W.M., F.-M.Z., J.-P.L., Z.-L.W., D.-M.Z., M.-L.L., X.-Y.S., B.-W.Z., C.-F.Z., Z.-H.D., W.-J.Y., Q.C., G.-L.L., T.Y., S.L., Q.-Q.P., S.F., Xia.-Y.W., X.Z., X.-Y.B., Y.-H.Q., P.-C.S., R.L., G.-Y.L., H.-C.L., B.P., L.-X.J., G.S., J.L., Z.-H.F., Y.-P.S., Y.-B.X., W.-Y.D., Xin-Y.W., X.L., X.-P.Z., D.D., Q.L., and Y.H. contributed primarily to sample collection and/or HLA genotyping. J.-W.C. and M.G. contributed to critical writing and review of the manuscript. All authors contributed to the final manuscript. J.S. and T.G. are the guarantors of this work and, as such, had full access to all the data in the study and take responsibility for the integrity of the data and the accuracy of the analysis.",
year = "2018",
month = may,
day = "1",
doi = "10.2337/db17-0852",
language = "English (US)",
volume = "67",
pages = "861--871",
journal = "Diabetes",
issn = "0012-1797",
publisher = "American Diabetes Association Inc.",
number = "5",
}