Abstract
Strong associations between HLA alleles and infectious and autoimmune diseases are well established. Although obesity is also associated with these diseases, the relationship between HLA and obesity has not been systematically investigated in a large cohort. In the current study, we analyzed the association of HLA alleles with BMI using data from 1.3 million healthy adult donors from the Chinese Marrow Donor Program (CMDP). We found 23 HLA alleles, including 12 low-resolution and 11 highresolution alleles, were significantly associated with BMI after correction for multiple testing. Alleles associated with high BMI were enriched in haplotypes that were common in both Chinese and European populations, whereas the alleles associated with low BMI were enriched in haplotypes common only in Asians. Alleles B∗07, DRB1∗07, DRB1∗12, and C∗03:02 provided the strongest associations with BMI (P = 6.89 × 10-10, 1.32 × 10-9, 1.52 × 10-9, and 4.45 × 10-8, respectively), where B∗07 and DRB1∗07 also had evidence for sex-specific effects (Pheterogeneity = 0.0067 and 0.00058, respectively). These results, which identify associations between alleles of HLA-B, DRB1, and C with BMI in Chinese young adults, implicate a novelbiological connection between HLA alleles and obesity.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 861-871 |
| Number of pages | 11 |
| Journal | Diabetes |
| Volume | 67 |
| Issue number | 5 |
| DOIs | |
| State | Published - May 1 2018 |
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ASJC Scopus subject areas
- Internal Medicine
- Endocrinology, Diabetes and Metabolism
Cite this
HLA-B∗07, HLA-DRB1∗07, HLA-DRB1∗12, and HLA-c∗03:02 strongly associate with BMI : Data from 1.3 million healthy Chinese adults. / Shen, Jie; Guo, Tingwei; Wang, Tao; Zhen, Yisong; Ma, Xiao; Wang, Yuan; Zhang, Zhi Xin; Cai, Jian Ping; Mao, Wei; Zhu, Fa Ming; Li, Jian Ping; Wang, Zhen Lei; Zhang, De Mei; Liu, Meng Li; Shan, Xiao Yan; Zhang, Bo Wei; Zhu, Chuan Fu; Deng, Zhi Hui; Yu, Wei Jian; Chen, Qiang; Li, Guo Liang; Yang, Tao; Lu, Shan; Pan, Qin Qin; Fan, Su; Wang, Xiao Yan; Zhao, Xing; Bi, Xin Yun; Qiao, Yan Hui; Su, Pin Can; Lv, Rong; Li, Guo Ying; Li, Heng Cong; Pei, Bin; Jiao, Li Xin; Shen, Gang; Liu, Jie; Feng, Zhi Hui; Su, Yu Ping; Xie, Yu Bin; Di, Wen Ying; Wang, Xin Yu; Liu, Xiang; Zhang, Xiao Ping; Du, Dan; Liu, Qi; Han, Ying; Chen, Jia Wei; Gu, Min; Baier, Leslie J.
In: Diabetes, Vol. 67, No. 5, 01.05.2018, p. 861-871.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - HLA-B∗07, HLA-DRB1∗07, HLA-DRB1∗12, and HLA-c∗03:02 strongly associate with BMI
T2 - Data from 1.3 million healthy Chinese adults
AU - Shen, Jie
AU - Guo, Tingwei
AU - Wang, Tao
AU - Zhen, Yisong
AU - Ma, Xiao
AU - Wang, Yuan
AU - Zhang, Zhi Xin
AU - Cai, Jian Ping
AU - Mao, Wei
AU - Zhu, Fa Ming
AU - Li, Jian Ping
AU - Wang, Zhen Lei
AU - Zhang, De Mei
AU - Liu, Meng Li
AU - Shan, Xiao Yan
AU - Zhang, Bo Wei
AU - Zhu, Chuan Fu
AU - Deng, Zhi Hui
AU - Yu, Wei Jian
AU - Chen, Qiang
AU - Li, Guo Liang
AU - Yang, Tao
AU - Lu, Shan
AU - Pan, Qin Qin
AU - Fan, Su
AU - Wang, Xiao Yan
AU - Zhao, Xing
AU - Bi, Xin Yun
AU - Qiao, Yan Hui
AU - Su, Pin Can
AU - Lv, Rong
AU - Li, Guo Ying
AU - Li, Heng Cong
AU - Pei, Bin
AU - Jiao, Li Xin
AU - Shen, Gang
AU - Liu, Jie
AU - Feng, Zhi Hui
AU - Su, Yu Ping
AU - Xie, Yu Bin
AU - Di, Wen Ying
AU - Wang, Xin Yu
AU - Liu, Xiang
AU - Zhang, Xiao Ping
AU - Du, Dan
AU - Liu, Qi
AU - Han, Ying
AU - Chen, Jia Wei
AU - Gu, Min
AU - Baier, Leslie J.
PY - 2018/5/1
Y1 - 2018/5/1
N2 - Strong associations between HLA alleles and infectious and autoimmune diseases are well established. Although obesity is also associated with these diseases, the relationship between HLA and obesity has not been systematically investigated in a large cohort. In the current study, we analyzed the association of HLA alleles with BMI using data from 1.3 million healthy adult donors from the Chinese Marrow Donor Program (CMDP). We found 23 HLA alleles, including 12 low-resolution and 11 highresolution alleles, were significantly associated with BMI after correction for multiple testing. Alleles associated with high BMI were enriched in haplotypes that were common in both Chinese and European populations, whereas the alleles associated with low BMI were enriched in haplotypes common only in Asians. Alleles B∗07, DRB1∗07, DRB1∗12, and C∗03:02 provided the strongest associations with BMI (P = 6.89 × 10-10, 1.32 × 10-9, 1.52 × 10-9, and 4.45 × 10-8, respectively), where B∗07 and DRB1∗07 also had evidence for sex-specific effects (Pheterogeneity = 0.0067 and 0.00058, respectively). These results, which identify associations between alleles of HLA-B, DRB1, and C with BMI in Chinese young adults, implicate a novelbiological connection between HLA alleles and obesity.
AB - Strong associations between HLA alleles and infectious and autoimmune diseases are well established. Although obesity is also associated with these diseases, the relationship between HLA and obesity has not been systematically investigated in a large cohort. In the current study, we analyzed the association of HLA alleles with BMI using data from 1.3 million healthy adult donors from the Chinese Marrow Donor Program (CMDP). We found 23 HLA alleles, including 12 low-resolution and 11 highresolution alleles, were significantly associated with BMI after correction for multiple testing. Alleles associated with high BMI were enriched in haplotypes that were common in both Chinese and European populations, whereas the alleles associated with low BMI were enriched in haplotypes common only in Asians. Alleles B∗07, DRB1∗07, DRB1∗12, and C∗03:02 provided the strongest associations with BMI (P = 6.89 × 10-10, 1.32 × 10-9, 1.52 × 10-9, and 4.45 × 10-8, respectively), where B∗07 and DRB1∗07 also had evidence for sex-specific effects (Pheterogeneity = 0.0067 and 0.00058, respectively). These results, which identify associations between alleles of HLA-B, DRB1, and C with BMI in Chinese young adults, implicate a novelbiological connection between HLA alleles and obesity.
UR - http://www.scopus.com/inward/record.url?scp=85046008629&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85046008629&partnerID=8YFLogxK
U2 - 10.2337/db17-0852
DO - 10.2337/db17-0852
M3 - Article
C2 - 29483183
AN - SCOPUS:85046008629
VL - 67
SP - 861
EP - 871
JO - Diabetes
JF - Diabetes
SN - 0012-1797
IS - 5
ER -