HIV treatment is associated with a twofold higher probability of raised triglycerides: Pooled analyses in 21 023 individuals in sub-Saharan Africa

K. Ekoru; E. H. Young; D. G. Dillon; D. Gurdasani; N. Stehouwer; D. Faurholt-Jepsen; N. S. Levitt; N. J. Crowther; M. Nyirenda; M. A. Njelekela; K. Ramaiya; O. Nyan; O. O. Adewole; K. Anastos; C. Compostella; J. A. Dave; C. M. Fourie; H. Friis; I. M. Kruger; C. T. Longenecker; D. P. Maher; E. Mutimura; C. E. Ndhlovu; G. Praygod; E. W. Pefura Yone; M. Pujades-Rodriguez; N. Range; M. U. Sani; M. Sanusi; A. E. Schutte; K. Sliwa; P. C. Tien; E. H. Vorster; C. Walsh; D. Gareta; F. Mashili; E. Sobngwi; C. Adebamowo; A. Kamali; J. Seeley; L. Smeeth; D. Pillay; A. A. Motala; P. Kaleebu; M. S. Sandhu

doi:10.1017/gheg.2018.7

HIV treatment is associated with a twofold higher probability of raised triglycerides: Pooled analyses in 21 023 individuals in sub-Saharan Africa

K. Ekoru, E. H. Young, D. G. Dillon, D. Gurdasani, N. Stehouwer, D. Faurholt-Jepsen, N. S. Levitt, N. J. Crowther, M. Nyirenda, M. A. Njelekela, K. Ramaiya, O. Nyan, O. O. Adewole, K. Anastos, C. Compostella, J. A. Dave, C. M. Fourie, H. Friis, I. M. Kruger, C. T. LongeneckerD. P. Maher, E. Mutimura, C. E. Ndhlovu, G. Praygod, E. W. Pefura Yone, M. Pujades-Rodriguez, N. Range, M. U. Sani, M. Sanusi, A. E. Schutte, K. Sliwa, P. C. Tien, E. H. Vorster, C. Walsh, D. Gareta, F. Mashili, E. Sobngwi, C. Adebamowo, A. Kamali, J. Seeley, L. Smeeth, D. Pillay, A. A. Motala, P. Kaleebu, M. S. Sandhu

Medicine

Research output: Contribution to journal › Article › peer-review

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Abstract

Background Anti-retroviral therapy (ART) regimes for HIV are associated with raised levels of circulating triglycerides (TGs) in western populations. However, there are limited data on the impact of ART on cardiometabolic risk in sub-Saharan African (SSA) populations.Methods Pooled analyses of 14 studies comprising 21 023 individuals, on whom relevant cardiometabolic risk factors (including TG), HIV and ART status were assessed between 2003 and 2014, in SSA. The association between ART and raised TG (>2.3 mmol/L) was analysed using regression models.Findings Among 10 615 individuals, ART was associated with a two-fold higher probability of raised TG (RR 2.05, 95% CI 1.51-2.77, I2 = 45.2%). The associations between ART and raised blood pressure, glucose, HbA1c, and other lipids were inconsistent across studies.Interpretation Evidence from this study confirms the association of ART with raised TG in SSA populations. Given the possible causal effect of raised TG on cardiovascular disease (CVD), the evidence highlights the need for prospective studies to clarify the impact of long term ART on CVD outcomes in SSA.

Original language	English (US)
Article number	e7
Journal	Global Health, Epidemiology and Genomics
Volume	3
DOIs	https://doi.org/10.1017/gheg.2018.7
State	Published - 2018

Keywords

Antiretroviral therapy
HIV
cardiovascular disease
lipids
sub-Saharan Africa
triglycerides

ASJC Scopus subject areas

Epidemiology
Public Health, Environmental and Occupational Health

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1017/gheg.2018.7

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Ekoru, K., Young, E. H., Dillon, D. G., Gurdasani, D., Stehouwer, N., Faurholt-Jepsen, D., Levitt, N. S., Crowther, N. J., Nyirenda, M., Njelekela, M. A., Ramaiya, K., Nyan, O., Adewole, O. O., Anastos, K., Compostella, C., Dave, J. A., Fourie, C. M., Friis, H., Kruger, I. M., ... Sandhu, M. S. (2018). HIV treatment is associated with a twofold higher probability of raised triglycerides: Pooled analyses in 21 023 individuals in sub-Saharan Africa. Global Health, Epidemiology and Genomics, 3, Article e7. https://doi.org/10.1017/gheg.2018.7

Ekoru, K, Young, EH, Dillon, DG, Gurdasani, D, Stehouwer, N, Faurholt-Jepsen, D, Levitt, NS, Crowther, NJ, Nyirenda, M, Njelekela, MA, Ramaiya, K, Nyan, O, Adewole, OO, Anastos, K, Compostella, C, Dave, JA, Fourie, CM, Friis, H, Kruger, IM, Longenecker, CT, Maher, DP, Mutimura, E, Ndhlovu, CE, Praygod, G, Pefura Yone, EW, Pujades-Rodriguez, M, Range, N, Sani, MU, Sanusi, M, Schutte, AE, Sliwa, K, Tien, PC, Vorster, EH, Walsh, C, Gareta, D, Mashili, F, Sobngwi, E, Adebamowo, C, Kamali, A, Seeley, J, Smeeth, L, Pillay, D, Motala, AA, Kaleebu, P & Sandhu, MS 2018, 'HIV treatment is associated with a twofold higher probability of raised triglycerides: Pooled analyses in 21 023 individuals in sub-Saharan Africa', Global Health, Epidemiology and Genomics, vol. 3, e7. https://doi.org/10.1017/gheg.2018.7

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title = "HIV treatment is associated with a twofold higher probability of raised triglycerides: Pooled analyses in 21 023 individuals in sub-Saharan Africa",

abstract = "Background Anti-retroviral therapy (ART) regimes for HIV are associated with raised levels of circulating triglycerides (TGs) in western populations. However, there are limited data on the impact of ART on cardiometabolic risk in sub-Saharan African (SSA) populations.Methods Pooled analyses of 14 studies comprising 21 023 individuals, on whom relevant cardiometabolic risk factors (including TG), HIV and ART status were assessed between 2003 and 2014, in SSA. The association between ART and raised TG (>2.3 mmol/L) was analysed using regression models.Findings Among 10 615 individuals, ART was associated with a two-fold higher probability of raised TG (RR 2.05, 95% CI 1.51-2.77, I2 = 45.2%). The associations between ART and raised blood pressure, glucose, HbA1c, and other lipids were inconsistent across studies.Interpretation Evidence from this study confirms the association of ART with raised TG in SSA populations. Given the possible causal effect of raised TG on cardiovascular disease (CVD), the evidence highlights the need for prospective studies to clarify the impact of long term ART on CVD outcomes in SSA.",

keywords = "Antiretroviral therapy, HIV, cardiovascular disease, lipids, sub-Saharan Africa, triglycerides",

author = "K. Ekoru and Young, {E. H.} and Dillon, {D. G.} and D. Gurdasani and N. Stehouwer and D. Faurholt-Jepsen and Levitt, {N. S.} and Crowther, {N. J.} and M. Nyirenda and Njelekela, {M. A.} and K. Ramaiya and O. Nyan and Adewole, {O. O.} and K. Anastos and C. Compostella and Dave, {J. A.} and Fourie, {C. M.} and H. Friis and Kruger, {I. M.} and Longenecker, {C. T.} and Maher, {D. P.} and E. Mutimura and Ndhlovu, {C. E.} and G. Praygod and {Pefura Yone}, {E. W.} and M. Pujades-Rodriguez and N. Range and Sani, {M. U.} and M. Sanusi and Schutte, {A. E.} and K. Sliwa and Tien, {P. C.} and Vorster, {E. H.} and C. Walsh and D. Gareta and F. Mashili and E. Sobngwi and C. Adebamowo and A. Kamali and J. Seeley and L. Smeeth and D. Pillay and Motala, {A. A.} and P. Kaleebu and Sandhu, {M. S.}",

note = "Publisher Copyright: Copyright {\textcopyright} The Author(s) 2018.",

year = "2018",

doi = "10.1017/gheg.2018.7",

language = "English (US)",

volume = "3",

journal = "Global Health, Epidemiology and Genomics",

issn = "2054-4200",

publisher = "Cambridge University Press",

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TY - JOUR

T1 - HIV treatment is associated with a twofold higher probability of raised triglycerides

T2 - Pooled analyses in 21 023 individuals in sub-Saharan Africa

AU - Ekoru, K.

AU - Young, E. H.

AU - Dillon, D. G.

AU - Gurdasani, D.

AU - Stehouwer, N.

AU - Faurholt-Jepsen, D.

AU - Levitt, N. S.

AU - Crowther, N. J.

AU - Nyirenda, M.

AU - Njelekela, M. A.

AU - Ramaiya, K.

AU - Nyan, O.

AU - Adewole, O. O.

AU - Anastos, K.

AU - Compostella, C.

AU - Dave, J. A.

AU - Fourie, C. M.

AU - Friis, H.

AU - Kruger, I. M.

AU - Longenecker, C. T.

AU - Maher, D. P.

AU - Mutimura, E.

AU - Ndhlovu, C. E.

AU - Praygod, G.

AU - Pefura Yone, E. W.

AU - Pujades-Rodriguez, M.

AU - Range, N.

AU - Sani, M. U.

AU - Sanusi, M.

AU - Schutte, A. E.

AU - Sliwa, K.

AU - Tien, P. C.

AU - Vorster, E. H.

AU - Walsh, C.

AU - Gareta, D.

AU - Mashili, F.

AU - Sobngwi, E.

AU - Adebamowo, C.

AU - Kamali, A.

AU - Seeley, J.

AU - Smeeth, L.

AU - Pillay, D.

AU - Motala, A. A.

AU - Kaleebu, P.

AU - Sandhu, M. S.

PY - 2018

Y1 - 2018

N2 - Background Anti-retroviral therapy (ART) regimes for HIV are associated with raised levels of circulating triglycerides (TGs) in western populations. However, there are limited data on the impact of ART on cardiometabolic risk in sub-Saharan African (SSA) populations.Methods Pooled analyses of 14 studies comprising 21 023 individuals, on whom relevant cardiometabolic risk factors (including TG), HIV and ART status were assessed between 2003 and 2014, in SSA. The association between ART and raised TG (>2.3 mmol/L) was analysed using regression models.Findings Among 10 615 individuals, ART was associated with a two-fold higher probability of raised TG (RR 2.05, 95% CI 1.51-2.77, I2 = 45.2%). The associations between ART and raised blood pressure, glucose, HbA1c, and other lipids were inconsistent across studies.Interpretation Evidence from this study confirms the association of ART with raised TG in SSA populations. Given the possible causal effect of raised TG on cardiovascular disease (CVD), the evidence highlights the need for prospective studies to clarify the impact of long term ART on CVD outcomes in SSA.

AB - Background Anti-retroviral therapy (ART) regimes for HIV are associated with raised levels of circulating triglycerides (TGs) in western populations. However, there are limited data on the impact of ART on cardiometabolic risk in sub-Saharan African (SSA) populations.Methods Pooled analyses of 14 studies comprising 21 023 individuals, on whom relevant cardiometabolic risk factors (including TG), HIV and ART status were assessed between 2003 and 2014, in SSA. The association between ART and raised TG (>2.3 mmol/L) was analysed using regression models.Findings Among 10 615 individuals, ART was associated with a two-fold higher probability of raised TG (RR 2.05, 95% CI 1.51-2.77, I2 = 45.2%). The associations between ART and raised blood pressure, glucose, HbA1c, and other lipids were inconsistent across studies.Interpretation Evidence from this study confirms the association of ART with raised TG in SSA populations. Given the possible causal effect of raised TG on cardiovascular disease (CVD), the evidence highlights the need for prospective studies to clarify the impact of long term ART on CVD outcomes in SSA.

KW - Antiretroviral therapy

KW - HIV

KW - cardiovascular disease

KW - lipids

KW - sub-Saharan Africa

KW - triglycerides

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U2 - 10.1017/gheg.2018.7

DO - 10.1017/gheg.2018.7

M3 - Article

C2 - 29881632

AN - SCOPUS:85057997325

SN - 2054-4200

VL - 3

JO - Global Health, Epidemiology and Genomics

JF - Global Health, Epidemiology and Genomics

M1 - e7

ER -

HIV treatment is associated with a twofold higher probability of raised triglycerides: Pooled analyses in 21 023 individuals in sub-Saharan Africa

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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