HIV treatment is associated with a twofold higher probability of raised triglycerides

Pooled analyses in 21 023 individuals in sub-Saharan Africa

K. Ekoru, E. H. Young, D. G. Dillon, D. Gurdasani, N. Stehouwer, D. Faurholt-Jepsen, N. S. Levitt, N. J. Crowther, M. Nyirenda, M. A. Njelekela, K. Ramaiya, O. Nyan, O. O. Adewole, Kathryn Anastos, C. Compostella, J. A. Dave, C. M. Fourie, H. Friis, I. M. Kruger, C. T. Longenecker & 25 others D. P. Maher, E. Mutimura, C. E. Ndhlovu, G. Praygod, E. W. Pefura Yone, M. Pujades-Rodriguez, N. Range, M. U. Sani, M. Sanusi, A. E. Schutte, K. Sliwa, P. C. Tien, E. H. Vorster, C. Walsh, D. Gareta, F. Mashili, E. Sobngwi, C. Adebamowo, A. Kamali, J. Seeley, L. Smeeth, D. Pillay, A. A. Motala, P. Kaleebu, M. S. Sandhu

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background Anti-retroviral therapy (ART) regimes for HIV are associated with raised levels of circulating triglycerides (TGs) in western populations. However, there are limited data on the impact of ART on cardiometabolic risk in sub-Saharan African (SSA) populations.Methods Pooled analyses of 14 studies comprising 21 023 individuals, on whom relevant cardiometabolic risk factors (including TG), HIV and ART status were assessed between 2003 and 2014, in SSA. The association between ART and raised TG (>2.3 mmol/L) was analysed using regression models.Findings Among 10 615 individuals, ART was associated with a two-fold higher probability of raised TG (RR 2.05, 95% CI 1.51-2.77, I2 = 45.2%). The associations between ART and raised blood pressure, glucose, HbA1c, and other lipids were inconsistent across studies.Interpretation Evidence from this study confirms the association of ART with raised TG in SSA populations. Given the possible causal effect of raised TG on cardiovascular disease (CVD), the evidence highlights the need for prospective studies to clarify the impact of long term ART on CVD outcomes in SSA.

Original languageEnglish (US)
Article numbere7
JournalGlobal Health, Epidemiology and Genomics
Volume3
DOIs
StatePublished - Jan 1 2018

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Africa South of the Sahara
Triglycerides
HIV
Therapeutics
Cardiovascular Diseases
Population
Blood Glucose
Prospective Studies
Blood Pressure
Lipids

Keywords

  • Antiretroviral therapy
  • cardiovascular disease
  • HIV
  • lipids
  • sub-Saharan Africa
  • triglycerides

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Epidemiology

Cite this

HIV treatment is associated with a twofold higher probability of raised triglycerides : Pooled analyses in 21 023 individuals in sub-Saharan Africa. / Ekoru, K.; Young, E. H.; Dillon, D. G.; Gurdasani, D.; Stehouwer, N.; Faurholt-Jepsen, D.; Levitt, N. S.; Crowther, N. J.; Nyirenda, M.; Njelekela, M. A.; Ramaiya, K.; Nyan, O.; Adewole, O. O.; Anastos, Kathryn; Compostella, C.; Dave, J. A.; Fourie, C. M.; Friis, H.; Kruger, I. M.; Longenecker, C. T.; Maher, D. P.; Mutimura, E.; Ndhlovu, C. E.; Praygod, G.; Pefura Yone, E. W.; Pujades-Rodriguez, M.; Range, N.; Sani, M. U.; Sanusi, M.; Schutte, A. E.; Sliwa, K.; Tien, P. C.; Vorster, E. H.; Walsh, C.; Gareta, D.; Mashili, F.; Sobngwi, E.; Adebamowo, C.; Kamali, A.; Seeley, J.; Smeeth, L.; Pillay, D.; Motala, A. A.; Kaleebu, P.; Sandhu, M. S.

In: Global Health, Epidemiology and Genomics, Vol. 3, e7, 01.01.2018.

Research output: Contribution to journalArticle

Ekoru, K, Young, EH, Dillon, DG, Gurdasani, D, Stehouwer, N, Faurholt-Jepsen, D, Levitt, NS, Crowther, NJ, Nyirenda, M, Njelekela, MA, Ramaiya, K, Nyan, O, Adewole, OO, Anastos, K, Compostella, C, Dave, JA, Fourie, CM, Friis, H, Kruger, IM, Longenecker, CT, Maher, DP, Mutimura, E, Ndhlovu, CE, Praygod, G, Pefura Yone, EW, Pujades-Rodriguez, M, Range, N, Sani, MU, Sanusi, M, Schutte, AE, Sliwa, K, Tien, PC, Vorster, EH, Walsh, C, Gareta, D, Mashili, F, Sobngwi, E, Adebamowo, C, Kamali, A, Seeley, J, Smeeth, L, Pillay, D, Motala, AA, Kaleebu, P & Sandhu, MS 2018, 'HIV treatment is associated with a twofold higher probability of raised triglycerides: Pooled analyses in 21 023 individuals in sub-Saharan Africa', Global Health, Epidemiology and Genomics, vol. 3, e7. https://doi.org/10.1017/gheg.2018.7
Ekoru, K. ; Young, E. H. ; Dillon, D. G. ; Gurdasani, D. ; Stehouwer, N. ; Faurholt-Jepsen, D. ; Levitt, N. S. ; Crowther, N. J. ; Nyirenda, M. ; Njelekela, M. A. ; Ramaiya, K. ; Nyan, O. ; Adewole, O. O. ; Anastos, Kathryn ; Compostella, C. ; Dave, J. A. ; Fourie, C. M. ; Friis, H. ; Kruger, I. M. ; Longenecker, C. T. ; Maher, D. P. ; Mutimura, E. ; Ndhlovu, C. E. ; Praygod, G. ; Pefura Yone, E. W. ; Pujades-Rodriguez, M. ; Range, N. ; Sani, M. U. ; Sanusi, M. ; Schutte, A. E. ; Sliwa, K. ; Tien, P. C. ; Vorster, E. H. ; Walsh, C. ; Gareta, D. ; Mashili, F. ; Sobngwi, E. ; Adebamowo, C. ; Kamali, A. ; Seeley, J. ; Smeeth, L. ; Pillay, D. ; Motala, A. A. ; Kaleebu, P. ; Sandhu, M. S. / HIV treatment is associated with a twofold higher probability of raised triglycerides : Pooled analyses in 21 023 individuals in sub-Saharan Africa. In: Global Health, Epidemiology and Genomics. 2018 ; Vol. 3.
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title = "HIV treatment is associated with a twofold higher probability of raised triglycerides: Pooled analyses in 21 023 individuals in sub-Saharan Africa",
abstract = "Background Anti-retroviral therapy (ART) regimes for HIV are associated with raised levels of circulating triglycerides (TGs) in western populations. However, there are limited data on the impact of ART on cardiometabolic risk in sub-Saharan African (SSA) populations.Methods Pooled analyses of 14 studies comprising 21 023 individuals, on whom relevant cardiometabolic risk factors (including TG), HIV and ART status were assessed between 2003 and 2014, in SSA. The association between ART and raised TG (>2.3 mmol/L) was analysed using regression models.Findings Among 10 615 individuals, ART was associated with a two-fold higher probability of raised TG (RR 2.05, 95{\%} CI 1.51-2.77, I2 = 45.2{\%}). The associations between ART and raised blood pressure, glucose, HbA1c, and other lipids were inconsistent across studies.Interpretation Evidence from this study confirms the association of ART with raised TG in SSA populations. Given the possible causal effect of raised TG on cardiovascular disease (CVD), the evidence highlights the need for prospective studies to clarify the impact of long term ART on CVD outcomes in SSA.",
keywords = "Antiretroviral therapy, cardiovascular disease, HIV, lipids, sub-Saharan Africa, triglycerides",
author = "K. Ekoru and Young, {E. H.} and Dillon, {D. G.} and D. Gurdasani and N. Stehouwer and D. Faurholt-Jepsen and Levitt, {N. S.} and Crowther, {N. J.} and M. Nyirenda and Njelekela, {M. A.} and K. Ramaiya and O. Nyan and Adewole, {O. O.} and Kathryn Anastos and C. Compostella and Dave, {J. A.} and Fourie, {C. M.} and H. Friis and Kruger, {I. M.} and Longenecker, {C. T.} and Maher, {D. P.} and E. Mutimura and Ndhlovu, {C. E.} and G. Praygod and {Pefura Yone}, {E. W.} and M. Pujades-Rodriguez and N. Range and Sani, {M. U.} and M. Sanusi and Schutte, {A. E.} and K. Sliwa and Tien, {P. C.} and Vorster, {E. H.} and C. Walsh and D. Gareta and F. Mashili and E. Sobngwi and C. Adebamowo and A. Kamali and J. Seeley and L. Smeeth and D. Pillay and Motala, {A. A.} and P. Kaleebu and Sandhu, {M. S.}",
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T1 - HIV treatment is associated with a twofold higher probability of raised triglycerides

T2 - Pooled analyses in 21 023 individuals in sub-Saharan Africa

AU - Ekoru, K.

AU - Young, E. H.

AU - Dillon, D. G.

AU - Gurdasani, D.

AU - Stehouwer, N.

AU - Faurholt-Jepsen, D.

AU - Levitt, N. S.

AU - Crowther, N. J.

AU - Nyirenda, M.

AU - Njelekela, M. A.

AU - Ramaiya, K.

AU - Nyan, O.

AU - Adewole, O. O.

AU - Anastos, Kathryn

AU - Compostella, C.

AU - Dave, J. A.

AU - Fourie, C. M.

AU - Friis, H.

AU - Kruger, I. M.

AU - Longenecker, C. T.

AU - Maher, D. P.

AU - Mutimura, E.

AU - Ndhlovu, C. E.

AU - Praygod, G.

AU - Pefura Yone, E. W.

AU - Pujades-Rodriguez, M.

AU - Range, N.

AU - Sani, M. U.

AU - Sanusi, M.

AU - Schutte, A. E.

AU - Sliwa, K.

AU - Tien, P. C.

AU - Vorster, E. H.

AU - Walsh, C.

AU - Gareta, D.

AU - Mashili, F.

AU - Sobngwi, E.

AU - Adebamowo, C.

AU - Kamali, A.

AU - Seeley, J.

AU - Smeeth, L.

AU - Pillay, D.

AU - Motala, A. A.

AU - Kaleebu, P.

AU - Sandhu, M. S.

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Background Anti-retroviral therapy (ART) regimes for HIV are associated with raised levels of circulating triglycerides (TGs) in western populations. However, there are limited data on the impact of ART on cardiometabolic risk in sub-Saharan African (SSA) populations.Methods Pooled analyses of 14 studies comprising 21 023 individuals, on whom relevant cardiometabolic risk factors (including TG), HIV and ART status were assessed between 2003 and 2014, in SSA. The association between ART and raised TG (>2.3 mmol/L) was analysed using regression models.Findings Among 10 615 individuals, ART was associated with a two-fold higher probability of raised TG (RR 2.05, 95% CI 1.51-2.77, I2 = 45.2%). The associations between ART and raised blood pressure, glucose, HbA1c, and other lipids were inconsistent across studies.Interpretation Evidence from this study confirms the association of ART with raised TG in SSA populations. Given the possible causal effect of raised TG on cardiovascular disease (CVD), the evidence highlights the need for prospective studies to clarify the impact of long term ART on CVD outcomes in SSA.

AB - Background Anti-retroviral therapy (ART) regimes for HIV are associated with raised levels of circulating triglycerides (TGs) in western populations. However, there are limited data on the impact of ART on cardiometabolic risk in sub-Saharan African (SSA) populations.Methods Pooled analyses of 14 studies comprising 21 023 individuals, on whom relevant cardiometabolic risk factors (including TG), HIV and ART status were assessed between 2003 and 2014, in SSA. The association between ART and raised TG (>2.3 mmol/L) was analysed using regression models.Findings Among 10 615 individuals, ART was associated with a two-fold higher probability of raised TG (RR 2.05, 95% CI 1.51-2.77, I2 = 45.2%). The associations between ART and raised blood pressure, glucose, HbA1c, and other lipids were inconsistent across studies.Interpretation Evidence from this study confirms the association of ART with raised TG in SSA populations. Given the possible causal effect of raised TG on cardiovascular disease (CVD), the evidence highlights the need for prospective studies to clarify the impact of long term ART on CVD outcomes in SSA.

KW - Antiretroviral therapy

KW - cardiovascular disease

KW - HIV

KW - lipids

KW - sub-Saharan Africa

KW - triglycerides

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DO - 10.1017/gheg.2018.7

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