HIV malaria co-infection is associated with atypical memory B cell expansion and a reduced antibody response to a broad array of Plasmodium falciparum antigens in Rwandan adults

Krishanthi S. Subramaniam, Jeff Skinner, Emil Ivan, Eugene Mutimura, Ryung S. Kim, Catherine M. Feintuch, Silvia Portugal, Kathryn Anastos, Peter D. Crompton, Johanna P. Daily

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

HIV infected individuals in malaria endemic areas experience more frequent and severe malaria episodes compared to non HIV infected. This clinical observation has been linked to a deficiency in antibody responses to Plasmodium falciparum antigens; however, prior studies have only focused on the antibody response to + T cell count and HIV viral load only partially explained variability in the breadth of P. falciparum-specific antibody responses. Taken together, these data indicate that HIV malaria co-infection is associated with an expansion of atypical MBCs and a diminished antibody response to a diverse array of P. falciparum antigens, thus offering mechanistic insight into the higher risk of malaria in HIV+ individuals.

Original languageEnglish (US)
Article numbere0124412
JournalPLoS One
Volume10
Issue number4
DOIs
StatePublished - Apr 1 2015

Fingerprint

Plasmodium falciparum
Coinfection
mixed infection
malaria
Malaria
B-lymphocytes
Antibody Formation
B-Lymphocytes
Cells
HIV
antigens
Antigens
Data storage equipment
antibodies
Antibodies
T-cells
viral load
Viral Load
T-lymphocytes
Cell Count

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

HIV malaria co-infection is associated with atypical memory B cell expansion and a reduced antibody response to a broad array of Plasmodium falciparum antigens in Rwandan adults. / Subramaniam, Krishanthi S.; Skinner, Jeff; Ivan, Emil; Mutimura, Eugene; Kim, Ryung S.; Feintuch, Catherine M.; Portugal, Silvia; Anastos, Kathryn; Crompton, Peter D.; Daily, Johanna P.

In: PLoS One, Vol. 10, No. 4, e0124412, 01.04.2015.

Research output: Contribution to journalArticle

Subramaniam, Krishanthi S. ; Skinner, Jeff ; Ivan, Emil ; Mutimura, Eugene ; Kim, Ryung S. ; Feintuch, Catherine M. ; Portugal, Silvia ; Anastos, Kathryn ; Crompton, Peter D. ; Daily, Johanna P. / HIV malaria co-infection is associated with atypical memory B cell expansion and a reduced antibody response to a broad array of Plasmodium falciparum antigens in Rwandan adults. In: PLoS One. 2015 ; Vol. 10, No. 4.
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