HIV infection and carotid artery intima-media thickness: Pooled analyses across 5 cohorts of the NHLBI HIV-CVD collaborative

David B. Hanna, Mengye Guo, Petra Bůžková, Tracie L. Miller, Wendy S. Post, James H. Stein, Judith S. Currier, Richard A. Kronmal, Matthew S. Freiberg, Siiri N. Bennett, Cecilia M. Shikuma, Kathryn Anastos, Yanjie Li, Russell P. Tracy, Howard N. Hodis, Joseph A. Delaney, Robert C. Kaplan

Research output: Contribution to journalArticlepeer-review

28 Scopus citations


Background. Age and human immunodeficiency virus (HIV) treatment may affect the association of HIV infection with atherosclerosis. Methods. We used identical carotid artery B-mode ultrasonographic methods in 5 cohorts participating in the National Heart, Lung, and Blood Institute HIV-CVD Collaborative to measure intima-media thickness of the right far wall of the common carotid artery (CCA-IMT) and carotid artery bifurcation (BIF-IMT) between 2010 and 2013. Participants aged 6-75 years were either HIV infected or uninfected. Linear regression assessed associations of CCA-IMT and BIF-IMT with HIV infection and cardiovascular disease risk factors, within age and HIV treatment groups. Adjustment variables included sex, race/ethnicity, smoking, height, weight, and use of antihypertensive and lipid-lowering drugs. Results. We studied 867 HIV-infected and 338 HIV-uninfected male and 696 HIV-infected and 246 HIV-uninfected female participants. Among both middle-aged (30-49 years) and older adults (50-75 years), HIV-infected participants had CCA-IMT and BIF-IMT values that were similar to or lower than those in HIV-uninfected participants. In contrast, among those aged 6-29 years, HIV infection was associated with higher CCA-IMT and BIF-IMT values. Among HIV-infected participants, associations of higher systolic blood pressure and lower high-density lipoprotein cholesterol with Carotid artery intima-media thickness strengthened with age. Conclusions. The effects of HIV on carotid artery structure may differ across the lifespan, with traditional determinants of cardiovascular disease burden playing a larger role and HIV playing a lesser role in older adults than in young adults and children.

Original languageEnglish (US)
Pages (from-to)249-256
Number of pages8
JournalClinical Infectious Diseases
Issue number2
StatePublished - 2021


  • Aging
  • Biomarker
  • Cardiovascular disease risk factors
  • Carotid artery intima-media thickness
  • HIV infection

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases


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