HIV-1 reverse transcriptase mutations that confer decreased in vitro susceptibility to anti-RT DNA aptamer RT1t49 confer cross resistance to other anti-RT aptamers but not to standard RT inhibitors

Medicine & Life Sciences

• Nucleotide Aptamers 100%
• Human immunodeficiency virus 1 reverse transcriptase 93%
• Reverse Transcriptase Inhibitors 82%
• RNA-Directed DNA Polymerase 79%
• Mutation 38%
• In Vitro Techniques 29%
• Ribonuclease H 28%
• Viruses 19%
• Reverse Transcription 8%
• HIV-1 8%
• Hypersensitivity 7%