Histoplasma capsulatum

Mechanisms for pathogenesis

Jamie Mittal, Maria G. Ponce, Inessa Gendlina, Joshua D. Nosanchuk

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Histoplasmosis, caused by the dimorphic environmental fungus Histoplasma capsulatum, is a major mycosis on the global stage. Acquisition of the fungus by mammalian hosts can be clinically silent or it can lead to life-threatening systemic disease, which can occur in immunologically intact or deficient hosts, albeit severe disease is more likely in the setting of compromised cellular immunity. H. capsulatum yeast cells are highly adapted to the mammalian host as they can effectively survive within intracellular niches in select phagocytic cells. Understanding the biological response by both the host and H. capsulatum will facilitate improved approaches to prevent and/or modify disease. This review presents our current understanding of the major pathogenic mechanisms involved in histoplasmosis.

Original languageEnglish (US)
Title of host publicationCurrent Topics in Microbiology and Immunology
PublisherSpringer Verlag
Pages157-191
Number of pages35
DOIs
StatePublished - Jan 1 2019

Publication series

NameCurrent Topics in Microbiology and Immunology
Volume422
ISSN (Print)0070-217X
ISSN (Electronic)2196-9965

Fingerprint

Histoplasma
Histoplasmosis
Fungi
Mycoses
Phagocytes
Cellular Immunity
Yeasts

Keywords

  • Histoplasma capsulatum
  • Histoplasmosis
  • Intracellular survival
  • Microbial pathogenesis
  • Virulence

ASJC Scopus subject areas

  • Immunology and Allergy
  • Microbiology
  • Immunology
  • Microbiology (medical)

Cite this

Mittal, J., Ponce, M. G., Gendlina, I., & Nosanchuk, J. D. (2019). Histoplasma capsulatum: Mechanisms for pathogenesis. In Current Topics in Microbiology and Immunology (pp. 157-191). (Current Topics in Microbiology and Immunology; Vol. 422). Springer Verlag. https://doi.org/10.1007/82_2018_114

Histoplasma capsulatum : Mechanisms for pathogenesis. / Mittal, Jamie; Ponce, Maria G.; Gendlina, Inessa; Nosanchuk, Joshua D.

Current Topics in Microbiology and Immunology. Springer Verlag, 2019. p. 157-191 (Current Topics in Microbiology and Immunology; Vol. 422).

Research output: Chapter in Book/Report/Conference proceedingChapter

Mittal, J, Ponce, MG, Gendlina, I & Nosanchuk, JD 2019, Histoplasma capsulatum: Mechanisms for pathogenesis. in Current Topics in Microbiology and Immunology. Current Topics in Microbiology and Immunology, vol. 422, Springer Verlag, pp. 157-191. https://doi.org/10.1007/82_2018_114
Mittal J, Ponce MG, Gendlina I, Nosanchuk JD. Histoplasma capsulatum: Mechanisms for pathogenesis. In Current Topics in Microbiology and Immunology. Springer Verlag. 2019. p. 157-191. (Current Topics in Microbiology and Immunology). https://doi.org/10.1007/82_2018_114
Mittal, Jamie ; Ponce, Maria G. ; Gendlina, Inessa ; Nosanchuk, Joshua D. / Histoplasma capsulatum : Mechanisms for pathogenesis. Current Topics in Microbiology and Immunology. Springer Verlag, 2019. pp. 157-191 (Current Topics in Microbiology and Immunology).
@inbook{8241f45203a84561883938bb49d582ae,
title = "Histoplasma capsulatum: Mechanisms for pathogenesis",
abstract = "Histoplasmosis, caused by the dimorphic environmental fungus Histoplasma capsulatum, is a major mycosis on the global stage. Acquisition of the fungus by mammalian hosts can be clinically silent or it can lead to life-threatening systemic disease, which can occur in immunologically intact or deficient hosts, albeit severe disease is more likely in the setting of compromised cellular immunity. H. capsulatum yeast cells are highly adapted to the mammalian host as they can effectively survive within intracellular niches in select phagocytic cells. Understanding the biological response by both the host and H. capsulatum will facilitate improved approaches to prevent and/or modify disease. This review presents our current understanding of the major pathogenic mechanisms involved in histoplasmosis.",
keywords = "Histoplasma capsulatum, Histoplasmosis, Intracellular survival, Microbial pathogenesis, Virulence",
author = "Jamie Mittal and Ponce, {Maria G.} and Inessa Gendlina and Nosanchuk, {Joshua D.}",
year = "2019",
month = "1",
day = "1",
doi = "10.1007/82_2018_114",
language = "English (US)",
series = "Current Topics in Microbiology and Immunology",
publisher = "Springer Verlag",
pages = "157--191",
booktitle = "Current Topics in Microbiology and Immunology",

}

TY - CHAP

T1 - Histoplasma capsulatum

T2 - Mechanisms for pathogenesis

AU - Mittal, Jamie

AU - Ponce, Maria G.

AU - Gendlina, Inessa

AU - Nosanchuk, Joshua D.

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Histoplasmosis, caused by the dimorphic environmental fungus Histoplasma capsulatum, is a major mycosis on the global stage. Acquisition of the fungus by mammalian hosts can be clinically silent or it can lead to life-threatening systemic disease, which can occur in immunologically intact or deficient hosts, albeit severe disease is more likely in the setting of compromised cellular immunity. H. capsulatum yeast cells are highly adapted to the mammalian host as they can effectively survive within intracellular niches in select phagocytic cells. Understanding the biological response by both the host and H. capsulatum will facilitate improved approaches to prevent and/or modify disease. This review presents our current understanding of the major pathogenic mechanisms involved in histoplasmosis.

AB - Histoplasmosis, caused by the dimorphic environmental fungus Histoplasma capsulatum, is a major mycosis on the global stage. Acquisition of the fungus by mammalian hosts can be clinically silent or it can lead to life-threatening systemic disease, which can occur in immunologically intact or deficient hosts, albeit severe disease is more likely in the setting of compromised cellular immunity. H. capsulatum yeast cells are highly adapted to the mammalian host as they can effectively survive within intracellular niches in select phagocytic cells. Understanding the biological response by both the host and H. capsulatum will facilitate improved approaches to prevent and/or modify disease. This review presents our current understanding of the major pathogenic mechanisms involved in histoplasmosis.

KW - Histoplasma capsulatum

KW - Histoplasmosis

KW - Intracellular survival

KW - Microbial pathogenesis

KW - Virulence

UR - http://www.scopus.com/inward/record.url?scp=85071788711&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85071788711&partnerID=8YFLogxK

U2 - 10.1007/82_2018_114

DO - 10.1007/82_2018_114

M3 - Chapter

T3 - Current Topics in Microbiology and Immunology

SP - 157

EP - 191

BT - Current Topics in Microbiology and Immunology

PB - Springer Verlag

ER -