Histoplasma capsulatum at the host-pathogen interface

Joshua D. Nosanchuk; Attila Gacser

doi:10.1016/j.micinf.2008.07.011

Histoplasma capsulatum at the host-pathogen interface

Joshua D. Nosanchuk, Attila Gacser

Medicine

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

Histoplasma capsulatum is the most common cause of invasive fungal pulmonary disease worldwide. The interaction of H. capsulatum with a host is a complex, dynamic process. Severe disease most commonly occurs in individuals with compromised immunity, and the increasing utilization of immunomodulators in medicine has revealed significant risks for reactivation disease in patients with latent histoplasmosis. Fortunately, there are well developed molecular tools and excellent animal models for studying H. capsulatum virulence and numerous recent advances have been made regarding the pathogenesis of this fungus that will improve our capacity to combat disease.

Original language	English (US)
Pages (from-to)	973-977
Number of pages	5
Journal	Microbes and Infection
Volume	10
Issue number	9
DOIs	https://doi.org/10.1016/j.micinf.2008.07.011
State	Published - Jul 2008

Keywords

Antibody
Genetics
Histoplasma capsulatum
Pathogenesis
Vaccine

ASJC Scopus subject areas

Microbiology
Immunology
Infectious Diseases

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10.1016/j.micinf.2008.07.011

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title = "Histoplasma capsulatum at the host-pathogen interface",

abstract = "Histoplasma capsulatum is the most common cause of invasive fungal pulmonary disease worldwide. The interaction of H. capsulatum with a host is a complex, dynamic process. Severe disease most commonly occurs in individuals with compromised immunity, and the increasing utilization of immunomodulators in medicine has revealed significant risks for reactivation disease in patients with latent histoplasmosis. Fortunately, there are well developed molecular tools and excellent animal models for studying H. capsulatum virulence and numerous recent advances have been made regarding the pathogenesis of this fungus that will improve our capacity to combat disease.",

keywords = "Antibody, Genetics, Histoplasma capsulatum, Pathogenesis, Vaccine",

author = "Nosanchuk, {Joshua D.} and Attila Gacser",

note = "Funding Information: JDN is supported in part by NIH AI056070-01A2. Because of space restrictions, we were able to cite only a fraction of the relevant literature and apologize to colleagues whose contributions may not be acknowledged in this paper. ",

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AU - Gacser, Attila

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N2 - Histoplasma capsulatum is the most common cause of invasive fungal pulmonary disease worldwide. The interaction of H. capsulatum with a host is a complex, dynamic process. Severe disease most commonly occurs in individuals with compromised immunity, and the increasing utilization of immunomodulators in medicine has revealed significant risks for reactivation disease in patients with latent histoplasmosis. Fortunately, there are well developed molecular tools and excellent animal models for studying H. capsulatum virulence and numerous recent advances have been made regarding the pathogenesis of this fungus that will improve our capacity to combat disease.

AB - Histoplasma capsulatum is the most common cause of invasive fungal pulmonary disease worldwide. The interaction of H. capsulatum with a host is a complex, dynamic process. Severe disease most commonly occurs in individuals with compromised immunity, and the increasing utilization of immunomodulators in medicine has revealed significant risks for reactivation disease in patients with latent histoplasmosis. Fortunately, there are well developed molecular tools and excellent animal models for studying H. capsulatum virulence and numerous recent advances have been made regarding the pathogenesis of this fungus that will improve our capacity to combat disease.

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KW - Genetics

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KW - Pathogenesis

KW - Vaccine

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Histoplasma capsulatum at the host-pathogen interface

Abstract

Keywords

ASJC Scopus subject areas

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