Abstract
Histoplasma capsulatum is the most common cause of invasive fungal pulmonary disease worldwide. The interaction of H. capsulatum with a host is a complex, dynamic process. Severe disease most commonly occurs in individuals with compromised immunity, and the increasing utilization of immunomodulators in medicine has revealed significant risks for reactivation disease in patients with latent histoplasmosis. Fortunately, there are well developed molecular tools and excellent animal models for studying H. capsulatum virulence and numerous recent advances have been made regarding the pathogenesis of this fungus that will improve our capacity to combat disease.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 973-977 |
| Number of pages | 5 |
| Journal | Microbes and Infection |
| Volume | 10 |
| Issue number | 9 |
| DOIs | |
| State | Published - Jul 2008 |
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Keywords
- Antibody
- Genetics
- Histoplasma capsulatum
- Pathogenesis
- Vaccine
ASJC Scopus subject areas
- Microbiology
- Immunology
- Infectious Diseases
Cite this
Histoplasma capsulatum at the host-pathogen interface. / Nosanchuk, Joshua D.; Gacser, Attila.
In: Microbes and Infection, Vol. 10, No. 9, 07.2008, p. 973-977.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Histoplasma capsulatum at the host-pathogen interface
AU - Nosanchuk, Joshua D.
AU - Gacser, Attila
PY - 2008/7
Y1 - 2008/7
N2 - Histoplasma capsulatum is the most common cause of invasive fungal pulmonary disease worldwide. The interaction of H. capsulatum with a host is a complex, dynamic process. Severe disease most commonly occurs in individuals with compromised immunity, and the increasing utilization of immunomodulators in medicine has revealed significant risks for reactivation disease in patients with latent histoplasmosis. Fortunately, there are well developed molecular tools and excellent animal models for studying H. capsulatum virulence and numerous recent advances have been made regarding the pathogenesis of this fungus that will improve our capacity to combat disease.
AB - Histoplasma capsulatum is the most common cause of invasive fungal pulmonary disease worldwide. The interaction of H. capsulatum with a host is a complex, dynamic process. Severe disease most commonly occurs in individuals with compromised immunity, and the increasing utilization of immunomodulators in medicine has revealed significant risks for reactivation disease in patients with latent histoplasmosis. Fortunately, there are well developed molecular tools and excellent animal models for studying H. capsulatum virulence and numerous recent advances have been made regarding the pathogenesis of this fungus that will improve our capacity to combat disease.
KW - Antibody
KW - Genetics
KW - Histoplasma capsulatum
KW - Pathogenesis
KW - Vaccine
UR - http://www.scopus.com/inward/record.url?scp=53649092145&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=53649092145&partnerID=8YFLogxK
U2 - 10.1016/j.micinf.2008.07.011
DO - 10.1016/j.micinf.2008.07.011
M3 - Article
C2 - 18672088
AN - SCOPUS:53649092145
VL - 10
SP - 973
EP - 977
JO - Microbes and Infection
JF - Microbes and Infection
SN - 1286-4579
IS - 9
ER -