Histoplasma capsulatum at the host-pathogen interface

Joshua D. Nosanchuk, Attila Gacser

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

Histoplasma capsulatum is the most common cause of invasive fungal pulmonary disease worldwide. The interaction of H. capsulatum with a host is a complex, dynamic process. Severe disease most commonly occurs in individuals with compromised immunity, and the increasing utilization of immunomodulators in medicine has revealed significant risks for reactivation disease in patients with latent histoplasmosis. Fortunately, there are well developed molecular tools and excellent animal models for studying H. capsulatum virulence and numerous recent advances have been made regarding the pathogenesis of this fungus that will improve our capacity to combat disease.

Original languageEnglish (US)
Pages (from-to)973-977
Number of pages5
JournalMicrobes and Infection
Volume10
Issue number9
DOIs
StatePublished - Jul 1 2008

Keywords

  • Antibody
  • Genetics
  • Histoplasma capsulatum
  • Pathogenesis
  • Vaccine

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Infectious Diseases

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