Histoplasma capsulatum at the host-pathogen interface

Joshua D. Nosanchuk; Attila Gacser

doi:10.1016/j.micinf.2008.07.011

Histoplasma capsulatum at the host-pathogen interface

Joshua D. Nosanchuk, Attila Gacser

Medicine

Research output: Contribution to journal › Article

23 Scopus citations

Abstract

Histoplasma capsulatum is the most common cause of invasive fungal pulmonary disease worldwide. The interaction of H. capsulatum with a host is a complex, dynamic process. Severe disease most commonly occurs in individuals with compromised immunity, and the increasing utilization of immunomodulators in medicine has revealed significant risks for reactivation disease in patients with latent histoplasmosis. Fortunately, there are well developed molecular tools and excellent animal models for studying H. capsulatum virulence and numerous recent advances have been made regarding the pathogenesis of this fungus that will improve our capacity to combat disease.

Original language	English (US)
Pages (from-to)	973-977
Number of pages	5
Journal	Microbes and Infection
Volume	10
Issue number	9
DOIs	https://doi.org/10.1016/j.micinf.2008.07.011
State	Published - Jul 1 2008

Fingerprint

Keywords

Antibody
Genetics
Histoplasma capsulatum
Pathogenesis
Vaccine

ASJC Scopus subject areas

Microbiology
Immunology
Infectious Diseases

Cite this

Nosanchuk, J. D., & Gacser, A. (2008). Histoplasma capsulatum at the host-pathogen interface. Microbes and Infection, 10(9), 973-977. https://doi.org/10.1016/j.micinf.2008.07.011

@article{90f26851a4734885ab3644a09edaccf4,

title = "Histoplasma capsulatum at the host-pathogen interface",

abstract = "Histoplasma capsulatum is the most common cause of invasive fungal pulmonary disease worldwide. The interaction of H. capsulatum with a host is a complex, dynamic process. Severe disease most commonly occurs in individuals with compromised immunity, and the increasing utilization of immunomodulators in medicine has revealed significant risks for reactivation disease in patients with latent histoplasmosis. Fortunately, there are well developed molecular tools and excellent animal models for studying H. capsulatum virulence and numerous recent advances have been made regarding the pathogenesis of this fungus that will improve our capacity to combat disease.",

keywords = "Antibody, Genetics, Histoplasma capsulatum, Pathogenesis, Vaccine",

author = "Nosanchuk, {Joshua D.} and Attila Gacser",

year = "2008",

month = jul

day = "1",

doi = "10.1016/j.micinf.2008.07.011",

language = "English (US)",

volume = "10",

pages = "973--977",

journal = "Microbes and Infection",

issn = "1286-4579",

publisher = "Elsevier Masson SAS",

number = "9",

}

TY - JOUR

T1 - Histoplasma capsulatum at the host-pathogen interface

AU - Nosanchuk, Joshua D.

AU - Gacser, Attila

PY - 2008/7/1

Y1 - 2008/7/1

N2 - Histoplasma capsulatum is the most common cause of invasive fungal pulmonary disease worldwide. The interaction of H. capsulatum with a host is a complex, dynamic process. Severe disease most commonly occurs in individuals with compromised immunity, and the increasing utilization of immunomodulators in medicine has revealed significant risks for reactivation disease in patients with latent histoplasmosis. Fortunately, there are well developed molecular tools and excellent animal models for studying H. capsulatum virulence and numerous recent advances have been made regarding the pathogenesis of this fungus that will improve our capacity to combat disease.

AB - Histoplasma capsulatum is the most common cause of invasive fungal pulmonary disease worldwide. The interaction of H. capsulatum with a host is a complex, dynamic process. Severe disease most commonly occurs in individuals with compromised immunity, and the increasing utilization of immunomodulators in medicine has revealed significant risks for reactivation disease in patients with latent histoplasmosis. Fortunately, there are well developed molecular tools and excellent animal models for studying H. capsulatum virulence and numerous recent advances have been made regarding the pathogenesis of this fungus that will improve our capacity to combat disease.

KW - Antibody

KW - Genetics

KW - Histoplasma capsulatum

KW - Pathogenesis

KW - Vaccine

UR - http://www.scopus.com/inward/record.url?scp=53649092145&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=53649092145&partnerID=8YFLogxK

U2 - 10.1016/j.micinf.2008.07.011

DO - 10.1016/j.micinf.2008.07.011

M3 - Article

C2 - 18672088

AN - SCOPUS:53649092145

VL - 10

SP - 973

EP - 977

JO - Microbes and Infection

JF - Microbes and Infection

SN - 1286-4579

IS - 9

ER -

Access to Document

10.1016/j.micinf.2008.07.011