Histoplasma capsulatum at the host-pathogen interface

Joshua D. Nosanchuk, Attila Gacser

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Histoplasma capsulatum is the most common cause of invasive fungal pulmonary disease worldwide. The interaction of H. capsulatum with a host is a complex, dynamic process. Severe disease most commonly occurs in individuals with compromised immunity, and the increasing utilization of immunomodulators in medicine has revealed significant risks for reactivation disease in patients with latent histoplasmosis. Fortunately, there are well developed molecular tools and excellent animal models for studying H. capsulatum virulence and numerous recent advances have been made regarding the pathogenesis of this fungus that will improve our capacity to combat disease.

Original languageEnglish (US)
Pages (from-to)973-977
Number of pages5
JournalMicrobes and Infection
Volume10
Issue number9
DOIs
StatePublished - Jul 2008

Fingerprint

Histoplasma
Fungal Lung Diseases
Histoplasmosis
Immunologic Factors
Virulence
Immunity
Fungi
Animal Models
Medicine

Keywords

  • Antibody
  • Genetics
  • Histoplasma capsulatum
  • Pathogenesis
  • Vaccine

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Infectious Diseases

Cite this

Histoplasma capsulatum at the host-pathogen interface. / Nosanchuk, Joshua D.; Gacser, Attila.

In: Microbes and Infection, Vol. 10, No. 9, 07.2008, p. 973-977.

Research output: Contribution to journalArticle

Nosanchuk, Joshua D. ; Gacser, Attila. / Histoplasma capsulatum at the host-pathogen interface. In: Microbes and Infection. 2008 ; Vol. 10, No. 9. pp. 973-977.
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