Histone deacetylase inhibitors are potent radiation protectants

Luca Paoluzzi; William D. Figg

doi:10.4161/cbt.3.7.931

Histone deacetylase inhibitors are potent radiation protectants

Luca Paoluzzi, William D. Figg

Research output: Contribution to journal › Short survey › peer-review

17 Scopus citations

Abstract

Radiation-induced acute and late injuries often represent a limit to the optimal delivery of radiotherapy in cancer patients. Chung et al. reported that histone deacetylase (HDAC) inhibitors, a novel class compound of gene modulators, might have a role in controlling different adverse effects from radiotherapy in preclinical models. They also showed how protection of normal tissues and inhibition of tumor growth might be possible at the same time.

Original language	English (US)
Pages (from-to)	612-613
Number of pages	2
Journal	Cancer Biology and Therapy
Volume	3
Issue number	7
DOIs	https://doi.org/10.4161/cbt.3.7.931
State	Published - Jul 2004
Externally published	Yes

Keywords

Cutaneous radiation syndrome
Histone deacetylase inhibitors
Phenylbutyrate
Radiotherapy

ASJC Scopus subject areas

Molecular Medicine
Oncology
Pharmacology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.4161/cbt.3.7.931

Cite this

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title = "Histone deacetylase inhibitors are potent radiation protectants",

abstract = "Radiation-induced acute and late injuries often represent a limit to the optimal delivery of radiotherapy in cancer patients. Chung et al. reported that histone deacetylase (HDAC) inhibitors, a novel class compound of gene modulators, might have a role in controlling different adverse effects from radiotherapy in preclinical models. They also showed how protection of normal tissues and inhibition of tumor growth might be possible at the same time.",

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AU - Paoluzzi, Luca

AU - Figg, William D.

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AB - Radiation-induced acute and late injuries often represent a limit to the optimal delivery of radiotherapy in cancer patients. Chung et al. reported that histone deacetylase (HDAC) inhibitors, a novel class compound of gene modulators, might have a role in controlling different adverse effects from radiotherapy in preclinical models. They also showed how protection of normal tissues and inhibition of tumor growth might be possible at the same time.

KW - Cutaneous radiation syndrome

KW - Histone deacetylase inhibitors

KW - Phenylbutyrate

KW - Radiotherapy

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M3 - Short survey

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ER -

Histone deacetylase inhibitors are potent radiation protectants

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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