Histochemical localization of superoxide production in experimental autoimmune uveitis

David C. Gritz, Carolina Montes, Lily R. Atalla, Guey Shuang Wu, Alex Sevanian, Narsing A. Rao

Research output: Contribution to journalArticle

30 Scopus citations

Abstract

Although the presence and role of oxygen reactive species in uveal inflammation is the subject of intense investigation, there is little direct evidence that oxygen metabolites are present at the site of inflammation. We used the nitroblue tetrazolium test for superoxide to determine production of this oxygen reactive species in experimental autoimmune uveitis (EAU). The choroidal tissues of animals with this disease contained intracellular, blue-staining granules. Most of the positive staining cells appeared to be polymorphonuclear leukocytes. This localization of superoxide in EAU is further evidence of the generation of oxygen reactive species in uveal inflammation.

Original languageEnglish (US)
Pages (from-to)927-931
Number of pages5
JournalCurrent Eye Research
Volume10
Issue number10
DOIs
StatePublished - Jan 1 1991

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

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    Gritz, D. C., Montes, C., Atalla, L. R., Wu, G. S., Sevanian, A., & Rao, N. A. (1991). Histochemical localization of superoxide production in experimental autoimmune uveitis. Current Eye Research, 10(10), 927-931. https://doi.org/10.3109/02713689109020328