Histochemical localization of superoxide production in experimental autoimmune uveitis

David C. Gritz, Carolina Montes, Lily R. Atalla, Guey Shuang Wu, Alex Sevanian, Narsing A. Rao

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Although the presence and role of oxygen reactive species in uveal inflammation is the subject of intense investigation, there is little direct evidence that oxygen metabolites are present at the site of inflammation. We used the nitroblue tetrazolium test for superoxide to determine production of this oxygen reactive species in experimental autoimmune uveitis (EAU). The choroidal tissues of animals with this disease contained intracellular, blue-staining granules. Most of the positive staining cells appeared to be polymorphonuclear leukocytes. This localization of superoxide in EAU is further evidence of the generation of oxygen reactive species in uveal inflammation.

Original languageEnglish (US)
Pages (from-to)927-931
Number of pages5
JournalCurrent Eye Research
Volume10
Issue number10
DOIs
StatePublished - 1991
Externally publishedYes

Fingerprint

Uveitis
Superoxides
Reactive Oxygen Species
Inflammation
Staining and Labeling
Nitroblue Tetrazolium
Animal Diseases
Neutrophils
Oxygen

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

Cite this

Gritz, D. C., Montes, C., Atalla, L. R., Wu, G. S., Sevanian, A., & Rao, N. A. (1991). Histochemical localization of superoxide production in experimental autoimmune uveitis. Current Eye Research, 10(10), 927-931. https://doi.org/10.3109/02713689109020328

Histochemical localization of superoxide production in experimental autoimmune uveitis. / Gritz, David C.; Montes, Carolina; Atalla, Lily R.; Wu, Guey Shuang; Sevanian, Alex; Rao, Narsing A.

In: Current Eye Research, Vol. 10, No. 10, 1991, p. 927-931.

Research output: Contribution to journalArticle

Gritz, DC, Montes, C, Atalla, LR, Wu, GS, Sevanian, A & Rao, NA 1991, 'Histochemical localization of superoxide production in experimental autoimmune uveitis', Current Eye Research, vol. 10, no. 10, pp. 927-931. https://doi.org/10.3109/02713689109020328
Gritz, David C. ; Montes, Carolina ; Atalla, Lily R. ; Wu, Guey Shuang ; Sevanian, Alex ; Rao, Narsing A. / Histochemical localization of superoxide production in experimental autoimmune uveitis. In: Current Eye Research. 1991 ; Vol. 10, No. 10. pp. 927-931.
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