Histamine enhances HIV-1-induced modulation of dendritic cells to skew naïve T cell differentiation toward regulatory T cells

Rong Rong Zhai, Ai Ping Jiang, Hai Bo Wang, Li Ma, Xiao Xin Ren, Jin Feng Jiang, Li Wu, Ji Fu Wei, Jian Hua Wang

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Altered cytokine profiles and imbalanced frequencies of CD4+ T helper cell subsets are thought to be linked with HIV-1/AIDS pathogenesis, but the causes need to be further clarified. Histamine, a biogenic amine with many functions, shows enhancement in HIV-1 infected individuals, which are considered to link with disease progression, but is poorly understood. This study investigated histamine-assisted HIV-1 modulation of dendritic cell (DC) functions. Histamine and HIV-1 showed a synergistic role in induction of interleukin-10; histamine inhibited HIV-1-induced IL-12 production from MDDCs (monocyte-derived DCs); notably, histamine augmented HIV-1-induced MDDC functional polarization and skewed naïve T cell differentiation toward regulatory T cells (Tregs). The results indicate the novel role of histamine in HIV-1-induced DC functional regulation, which promoted Treg cell differentiation and up-regulated immunosuppressive factors. These findings help to bridge the correlation between elevated histamine and increased Treg cell frequency in HIV-1 infected individuals, and add to our understanding of HIV-1-induced immunosuppression.

Original languageEnglish (US)
Pages (from-to)163-172
Number of pages10
JournalVirology
Volume442
Issue number2
DOIs
StatePublished - Aug 1 2013
Externally publishedYes

Keywords

  • Dendritic cells
  • Histamine
  • HIV-1
  • Indoleamine 2,3-dioxygenase
  • Regulatory T cells

ASJC Scopus subject areas

  • Virology

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