Hippocampal neuropeptide Y mRNA is reduced in a strain of learned helpless resistant rats

Herbert M. Lachman; Demitri F. Papolos; Elyse D. Weiner; Reza Ramazankhana; Christopher Hartnick; Emmeline Edwards; Fritz A. Henn

doi:10.1016/0169-328X(92)90015-4

Hippocampal neuropeptide Y mRNA is reduced in a strain of learned helpless resistant rats

Herbert M. Lachman, Demitri F. Papolos, Elyse D. Weiner, Reza Ramazankhana, Christopher Hartnick, Emmeline Edwards, Fritz A. Henn

Psychiatry and Behavioral Sciences

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

The learned helpless rat is considered to be one of the better animal models of depression. A genetically inbred strain with a high vulnerability to develop helplessness (LH), as well as a highly resistant strain (NLH) have both been developed. Since the brain peptide neuropeptide Y (NPY) is involved in the regulation of a number of behaviors known to be altered in clinical depression as well as in learned helplessness, we measured the relative level of NPY mRNA in the hippocampus and cortex of control Sprague Dawley (SD), LH and NLH rats. We find that NLH rats have approximately a 30-35% decrease in basal hippocampal NPY mRNA compared with SD and LH rats. By contrast, cortical NPY mRNA and hippocampal pre-proenkephalin and somatostatin mRNA levels were not significantly different in the 3 strains. The data suggest that the regulation of NPY gene expression may be involved in the reduced vulnerability of NLH rats to develop learned helplessness.

Original language	English (US)
Pages (from-to)	94-100
Number of pages	7
Journal	Molecular Brain Research
Volume	14
Issue number	1-2
DOIs	https://doi.org/10.1016/0169-328X(92)90015-4
State	Published - Jun 1992

Keywords

Gene expression
Hippocampus
Learned helplessness
Neuropeptide Y

ASJC Scopus subject areas

Molecular Biology
Cellular and Molecular Neuroscience

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10.1016/0169-328X(92)90015-4

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title = "Hippocampal neuropeptide Y mRNA is reduced in a strain of learned helpless resistant rats",

abstract = "The learned helpless rat is considered to be one of the better animal models of depression. A genetically inbred strain with a high vulnerability to develop helplessness (LH), as well as a highly resistant strain (NLH) have both been developed. Since the brain peptide neuropeptide Y (NPY) is involved in the regulation of a number of behaviors known to be altered in clinical depression as well as in learned helplessness, we measured the relative level of NPY mRNA in the hippocampus and cortex of control Sprague Dawley (SD), LH and NLH rats. We find that NLH rats have approximately a 30-35% decrease in basal hippocampal NPY mRNA compared with SD and LH rats. By contrast, cortical NPY mRNA and hippocampal pre-proenkephalin and somatostatin mRNA levels were not significantly different in the 3 strains. The data suggest that the regulation of NPY gene expression may be involved in the reduced vulnerability of NLH rats to develop learned helplessness.",

keywords = "Gene expression, Hippocampus, Learned helplessness, Neuropeptide Y",

author = "Lachman, {Herbert M.} and Papolos, {Demitri F.} and Weiner, {Elyse D.} and Reza Ramazankhana and Christopher Hartnick and Emmeline Edwards and Henn, {Fritz A.}",

note = "Funding Information: Acknowledgements The Program in Behavioral Genetics is supported by the Ruane Family Fund and the G Harold and Leda Y Mathers charitable foundation H.M L is a fellow of the Irma T Hlrschl and Monique Wedl-Cauher charitable trust D FP is a NARSAD young investigator and is a reoplent of a Physiclan/So-entist Career Development Award from the NIMH (1K20MH00873-01A2) F A H and E E are recipients of Bristol-Myer and NSF grants respectively The authors wish to thank Drs G Hemnch, G Schwarz, S Zukm and J Kessler for kindly providing recombinant plasmlds and George Wright, Cynthia Michel, Phyllis Van Houten and Judy Shlvak for technical assistance We would also hke to acknowledge Dr Herman van Praag for his encouragement and support in establishing the Program of Behavioral Genetics",

year = "1992",

month = jun,

doi = "10.1016/0169-328X(92)90015-4",

language = "English (US)",

volume = "14",

pages = "94--100",

journal = "Molecular Brain Research",

issn = "0169-328X",

publisher = "Elsevier",

number = "1-2",

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TY - JOUR

T1 - Hippocampal neuropeptide Y mRNA is reduced in a strain of learned helpless resistant rats

AU - Lachman, Herbert M.

AU - Papolos, Demitri F.

AU - Weiner, Elyse D.

AU - Ramazankhana, Reza

AU - Hartnick, Christopher

AU - Edwards, Emmeline

AU - Henn, Fritz A.

N1 - Funding Information: Acknowledgements The Program in Behavioral Genetics is supported by the Ruane Family Fund and the G Harold and Leda Y Mathers charitable foundation H.M L is a fellow of the Irma T Hlrschl and Monique Wedl-Cauher charitable trust D FP is a NARSAD young investigator and is a reoplent of a Physiclan/So-entist Career Development Award from the NIMH (1K20MH00873-01A2) F A H and E E are recipients of Bristol-Myer and NSF grants respectively The authors wish to thank Drs G Hemnch, G Schwarz, S Zukm and J Kessler for kindly providing recombinant plasmlds and George Wright, Cynthia Michel, Phyllis Van Houten and Judy Shlvak for technical assistance We would also hke to acknowledge Dr Herman van Praag for his encouragement and support in establishing the Program of Behavioral Genetics

PY - 1992/6

Y1 - 1992/6

N2 - The learned helpless rat is considered to be one of the better animal models of depression. A genetically inbred strain with a high vulnerability to develop helplessness (LH), as well as a highly resistant strain (NLH) have both been developed. Since the brain peptide neuropeptide Y (NPY) is involved in the regulation of a number of behaviors known to be altered in clinical depression as well as in learned helplessness, we measured the relative level of NPY mRNA in the hippocampus and cortex of control Sprague Dawley (SD), LH and NLH rats. We find that NLH rats have approximately a 30-35% decrease in basal hippocampal NPY mRNA compared with SD and LH rats. By contrast, cortical NPY mRNA and hippocampal pre-proenkephalin and somatostatin mRNA levels were not significantly different in the 3 strains. The data suggest that the regulation of NPY gene expression may be involved in the reduced vulnerability of NLH rats to develop learned helplessness.

AB - The learned helpless rat is considered to be one of the better animal models of depression. A genetically inbred strain with a high vulnerability to develop helplessness (LH), as well as a highly resistant strain (NLH) have both been developed. Since the brain peptide neuropeptide Y (NPY) is involved in the regulation of a number of behaviors known to be altered in clinical depression as well as in learned helplessness, we measured the relative level of NPY mRNA in the hippocampus and cortex of control Sprague Dawley (SD), LH and NLH rats. We find that NLH rats have approximately a 30-35% decrease in basal hippocampal NPY mRNA compared with SD and LH rats. By contrast, cortical NPY mRNA and hippocampal pre-proenkephalin and somatostatin mRNA levels were not significantly different in the 3 strains. The data suggest that the regulation of NPY gene expression may be involved in the reduced vulnerability of NLH rats to develop learned helplessness.

KW - Gene expression

KW - Hippocampus

KW - Learned helplessness

KW - Neuropeptide Y

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AN - SCOPUS:0026724544

SN - 0169-328X

VL - 14

SP - 94

EP - 100

JO - Molecular Brain Research

JF - Molecular Brain Research

IS - 1-2

ER -

Hippocampal neuropeptide Y mRNA is reduced in a strain of learned helpless resistant rats

Abstract

Keywords

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