Hind limb somatosensory evoked potentials in the monkey: The effects of distal axonopathy

Joseph C. Arezzo, H. H. Schaumburg, H. G. Vaughan, P. S. Spencer, J. Barna

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Computer-averaged short-latency somatosensory evoked potentials (SLSEP) to unilateral stimulation of the peroneal nerve were recorded from surface electrodes overlying the peripheral nerve, cauda equina, spinal cord, brainstem, and contralateral sensorimotor region. Seven monkeys were studied under normal conditions and at various stages of distal axonopathy induced by systematic acrylamide intoxication. With the use of the noncephalic reference, a series of five small-amplitude positive components were identified that precede the initial cortical activity. On the basis of timing and topography of the components, the source of the first one, SLSEP1, was localized to the lumbar dorsal root fibers and that of the second, SLSEP2, to the ascending spinal tracts, principally the gracile fasciculus. Bipolar recordings of the SLSEP2 overlying the rostral extreme of the cervical spinal cord provided a sensitive measure of the onset of distal axonopathy. Changes in the timing of this component antedated both abnormalities of spinal or peripheral nerve conduction and behavioural signs of intoxication. The initial alteration was specific to stimulation of the hind limb and was associated with early morphological change limited to the terminal preterminal portions of the long axons in the gracile fasciculus.

Original languageEnglish (US)
Pages (from-to)24-32
Number of pages9
JournalAnnals of Neurology
Volume12
Issue number1
DOIs
StatePublished - 1982

Fingerprint

Somatosensory Evoked Potentials
Peripheral Nerves
Haplorhini
Extremities
Cauda Equina
Spinal Nerves
Peroneal Nerve
Acrylamide
Spinal Nerve Roots
Neural Conduction
Brain Stem
Axons
Spinal Cord
Electrodes
Cervical Cord

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Hind limb somatosensory evoked potentials in the monkey : The effects of distal axonopathy. / Arezzo, Joseph C.; Schaumburg, H. H.; Vaughan, H. G.; Spencer, P. S.; Barna, J.

In: Annals of Neurology, Vol. 12, No. 1, 1982, p. 24-32.

Research output: Contribution to journalArticle

Arezzo, Joseph C. ; Schaumburg, H. H. ; Vaughan, H. G. ; Spencer, P. S. ; Barna, J. / Hind limb somatosensory evoked potentials in the monkey : The effects of distal axonopathy. In: Annals of Neurology. 1982 ; Vol. 12, No. 1. pp. 24-32.
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