Higher rates and clustering of abnormal lipids, obesity, and diabetes mellitus in psoriatic arthritis compared with rheumatoid arthritis

Monalyn Labitigan, Asena Bahče-Altuntas, Joel M. Kremer, George Reed, Jeff D. Greenberg, Nicole Jordan, Chaim Putterman, Anna R. Broder

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

Objective We compared the prevalence and the clustering of the metabolic syndrome (MetS) components (obese body mass index [BMI; ≥30 kg/m 2], hypertriglyceridemia, low high-density lipids, hypertension, and diabetes mellitus) in patients with psoriatic arthritis (PsA) and rheumatoid arthritis (RA) in the Consortium of Rheumatology Researchers of North America (CORRONA) Registry. Methods We included CORRONA participants with a rheumatologist-confirmed clinical diagnosis of PsA or RA with complete data. We used a modified definition of MetS that did not include insulin resistance, waist circumference, or blood pressure measurements. Logistic regression models were adjusted for age, sex, and race. Results In the overall CORRONA population, the rates of diabetes mellitus and obesity were significantly higher in PsA compared with RA. In 294 PsA and 1,162 RA participants who had lipids measured, the overall prevalence of MetS in PsA versus RA was 27% versus 19%. The odds ratio (OR) of MetS in PsA versus RA was 1.44 (95% confidence interval [95% CI] 1.05-1.96, P = 0.02). The prevalence of hypertriglyceridemia was higher in PsA compared with RA (38% versus 28%; OR 1.51 [95% CI 1.15-1.98], P = 0.003). The prevalence of type 2 diabetes mellitus was also higher in PsA compared with RA (15% versus 11%; OR 1.56 [95% CI 1.07-2.28], P = 0.02) in the adjusted model. Similarly, higher rates of hypertriglyceridemia and diabetes mellitus were observed in the subgroup of PsA and RA patients with obese BMI. Conclusion Compared with RA, PsA is associated with higher rates of obesity, diabetes mellitus, and hypertriglyceridemia.

Original languageEnglish (US)
Pages (from-to)600-607
Number of pages8
JournalArthritis Care and Research
Volume66
Issue number4
DOIs
StatePublished - 2014

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Psoriatic Arthritis
Cluster Analysis
Rheumatoid Arthritis
Diabetes Mellitus
Obesity
Lipids
Hypertriglyceridemia
Rheumatology
North America
Odds Ratio
Research Personnel
Confidence Intervals
Logistic Models
Waist Circumference
Type 2 Diabetes Mellitus
Registries
Insulin Resistance
Body Mass Index
Blood Pressure
Hypertension

ASJC Scopus subject areas

  • Rheumatology

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Higher rates and clustering of abnormal lipids, obesity, and diabetes mellitus in psoriatic arthritis compared with rheumatoid arthritis. / Labitigan, Monalyn; Bahče-Altuntas, Asena; Kremer, Joel M.; Reed, George; Greenberg, Jeff D.; Jordan, Nicole; Putterman, Chaim; Broder, Anna R.

In: Arthritis Care and Research, Vol. 66, No. 4, 2014, p. 600-607.

Research output: Contribution to journalArticle

Labitigan, Monalyn ; Bahče-Altuntas, Asena ; Kremer, Joel M. ; Reed, George ; Greenberg, Jeff D. ; Jordan, Nicole ; Putterman, Chaim ; Broder, Anna R. / Higher rates and clustering of abnormal lipids, obesity, and diabetes mellitus in psoriatic arthritis compared with rheumatoid arthritis. In: Arthritis Care and Research. 2014 ; Vol. 66, No. 4. pp. 600-607.
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AU - Reed, George

AU - Greenberg, Jeff D.

AU - Jordan, Nicole

AU - Putterman, Chaim

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AB - Objective We compared the prevalence and the clustering of the metabolic syndrome (MetS) components (obese body mass index [BMI; ≥30 kg/m 2], hypertriglyceridemia, low high-density lipids, hypertension, and diabetes mellitus) in patients with psoriatic arthritis (PsA) and rheumatoid arthritis (RA) in the Consortium of Rheumatology Researchers of North America (CORRONA) Registry. Methods We included CORRONA participants with a rheumatologist-confirmed clinical diagnosis of PsA or RA with complete data. We used a modified definition of MetS that did not include insulin resistance, waist circumference, or blood pressure measurements. Logistic regression models were adjusted for age, sex, and race. Results In the overall CORRONA population, the rates of diabetes mellitus and obesity were significantly higher in PsA compared with RA. In 294 PsA and 1,162 RA participants who had lipids measured, the overall prevalence of MetS in PsA versus RA was 27% versus 19%. The odds ratio (OR) of MetS in PsA versus RA was 1.44 (95% confidence interval [95% CI] 1.05-1.96, P = 0.02). The prevalence of hypertriglyceridemia was higher in PsA compared with RA (38% versus 28%; OR 1.51 [95% CI 1.15-1.98], P = 0.003). The prevalence of type 2 diabetes mellitus was also higher in PsA compared with RA (15% versus 11%; OR 1.56 [95% CI 1.07-2.28], P = 0.02) in the adjusted model. Similarly, higher rates of hypertriglyceridemia and diabetes mellitus were observed in the subgroup of PsA and RA patients with obese BMI. Conclusion Compared with RA, PsA is associated with higher rates of obesity, diabetes mellitus, and hypertriglyceridemia.

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