Higher Body Mass Index is Associated with Greater Proportions of Effector CD8+ T cells Expressing CD57 in Women Living with HIV

for the Women’s Interagency HIV Study (WIHS)

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

BACKGROUND:: A low proportion of CD28-CD8+ T cells that express CD57 is associated with increased mortality in HIV infection. The effect of increasing BMI changes in the proportion of CD57+CD28-CD8+ T cells among HIV-infected individuals on ART is unknown. SETTING:: In a U.S. cohort of HIV-infected women, we evaluated associations of BMI and waist circumference with 3 distinct CD8+ T cell phenotypes: % CD28-CD57+CD8+ T cells, % CD57+ of CD28-CD8+ T cells and % CD28- of all CD8 T cells. METHODS:: Multivariable linear regression analysis was used to estimate beta-coefficients for each of three T cell phenotypes. Covariates included HIV parameters (current and nadir CD4, current viral load), demographics (age, race, income, study site), and lifestyle (tobacco, alcohol use) factors. RESULTS:: Of 225 participants, the median age was 46 years and 50% were obese (BMI>30 m/kg). Greater BMI and waist circumference were both associated with higher %CD28-CD57+CD8+ T cells and %CD57+ of all CD28-CD8+ T cells in multivariable analysis, including adjustment for HIV viral load (all p<0.05). The association between greater BMI and the overall proportion of CD28 CD8+ cells in fully adjusted models (0.078, 95% CI: (-0.053 - 0.209) were not significant. CONCLUSIONS:: In this analysis, greater BMI and waist circumference are associated with greater expression of CD57 on CD28-CD8+ T cells and a greater proportion of CD57+CD28- CD8+ T cells. These findings may indicate that increasing BMI is immunologically protective in HIV-infected women. Future research is needed to understand the prognostic importance of these associations on clinical outcomes.

Original languageEnglish (US)
JournalJournal of Acquired Immune Deficiency Syndromes
DOIs
StateAccepted/In press - Mar 20 2017

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Body Mass Index
HIV
T-Lymphocytes
Waist Circumference
Viral Load
Phenotype
Tobacco Use
HIV Infections
Life Style
Linear Models
Regression Analysis
Alcohols
Demography
Mortality

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Infectious Diseases

Cite this

Higher Body Mass Index is Associated with Greater Proportions of Effector CD8+ T cells Expressing CD57 in Women Living with HIV. / for the Women’s Interagency HIV Study (WIHS).

In: Journal of Acquired Immune Deficiency Syndromes, 20.03.2017.

Research output: Contribution to journalArticle

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title = "Higher Body Mass Index is Associated with Greater Proportions of Effector CD8+ T cells Expressing CD57 in Women Living with HIV",
abstract = "BACKGROUND:: A low proportion of CD28-CD8+ T cells that express CD57 is associated with increased mortality in HIV infection. The effect of increasing BMI changes in the proportion of CD57+CD28-CD8+ T cells among HIV-infected individuals on ART is unknown. SETTING:: In a U.S. cohort of HIV-infected women, we evaluated associations of BMI and waist circumference with 3 distinct CD8+ T cell phenotypes: {\%} CD28-CD57+CD8+ T cells, {\%} CD57+ of CD28-CD8+ T cells and {\%} CD28- of all CD8 T cells. METHODS:: Multivariable linear regression analysis was used to estimate beta-coefficients for each of three T cell phenotypes. Covariates included HIV parameters (current and nadir CD4, current viral load), demographics (age, race, income, study site), and lifestyle (tobacco, alcohol use) factors. RESULTS:: Of 225 participants, the median age was 46 years and 50{\%} were obese (BMI>30 m/kg). Greater BMI and waist circumference were both associated with higher {\%}CD28-CD57+CD8+ T cells and {\%}CD57+ of all CD28-CD8+ T cells in multivariable analysis, including adjustment for HIV viral load (all p<0.05). The association between greater BMI and the overall proportion of CD28 CD8+ cells in fully adjusted models (0.078, 95{\%} CI: (-0.053 - 0.209) were not significant. CONCLUSIONS:: In this analysis, greater BMI and waist circumference are associated with greater expression of CD57 on CD28-CD8+ T cells and a greater proportion of CD57+CD28- CD8+ T cells. These findings may indicate that increasing BMI is immunologically protective in HIV-infected women. Future research is needed to understand the prognostic importance of these associations on clinical outcomes.",
author = "{for the Women’s Interagency HIV Study (WIHS)} and Reid, {Michael J A} and Baxi, {Sanjiv M.} and Sheira, {Lila A.} and Landay, {Alan L.} and Frongillo, {Edward A.} and Adedimeji, {Adebola A.} and Cohen, {Mardge H.} and Eryka Wentz and Gustafson, {Deborah R R} and Daniel Merenstein and Hunt, {Peter W.} and Tien, {Phyllis C.} and Kathryn Anastos",
year = "2017",
month = "3",
day = "20",
doi = "10.1097/QAI.0000000000001376",
language = "English (US)",
journal = "Journal of Acquired Immune Deficiency Syndromes",
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T1 - Higher Body Mass Index is Associated with Greater Proportions of Effector CD8+ T cells Expressing CD57 in Women Living with HIV

AU - for the Women’s Interagency HIV Study (WIHS)

AU - Reid, Michael J A

AU - Baxi, Sanjiv M.

AU - Sheira, Lila A.

AU - Landay, Alan L.

AU - Frongillo, Edward A.

AU - Adedimeji, Adebola A.

AU - Cohen, Mardge H.

AU - Wentz, Eryka

AU - Gustafson, Deborah R R

AU - Merenstein, Daniel

AU - Hunt, Peter W.

AU - Tien, Phyllis C.

AU - Anastos, Kathryn

PY - 2017/3/20

Y1 - 2017/3/20

N2 - BACKGROUND:: A low proportion of CD28-CD8+ T cells that express CD57 is associated with increased mortality in HIV infection. The effect of increasing BMI changes in the proportion of CD57+CD28-CD8+ T cells among HIV-infected individuals on ART is unknown. SETTING:: In a U.S. cohort of HIV-infected women, we evaluated associations of BMI and waist circumference with 3 distinct CD8+ T cell phenotypes: % CD28-CD57+CD8+ T cells, % CD57+ of CD28-CD8+ T cells and % CD28- of all CD8 T cells. METHODS:: Multivariable linear regression analysis was used to estimate beta-coefficients for each of three T cell phenotypes. Covariates included HIV parameters (current and nadir CD4, current viral load), demographics (age, race, income, study site), and lifestyle (tobacco, alcohol use) factors. RESULTS:: Of 225 participants, the median age was 46 years and 50% were obese (BMI>30 m/kg). Greater BMI and waist circumference were both associated with higher %CD28-CD57+CD8+ T cells and %CD57+ of all CD28-CD8+ T cells in multivariable analysis, including adjustment for HIV viral load (all p<0.05). The association between greater BMI and the overall proportion of CD28 CD8+ cells in fully adjusted models (0.078, 95% CI: (-0.053 - 0.209) were not significant. CONCLUSIONS:: In this analysis, greater BMI and waist circumference are associated with greater expression of CD57 on CD28-CD8+ T cells and a greater proportion of CD57+CD28- CD8+ T cells. These findings may indicate that increasing BMI is immunologically protective in HIV-infected women. Future research is needed to understand the prognostic importance of these associations on clinical outcomes.

AB - BACKGROUND:: A low proportion of CD28-CD8+ T cells that express CD57 is associated with increased mortality in HIV infection. The effect of increasing BMI changes in the proportion of CD57+CD28-CD8+ T cells among HIV-infected individuals on ART is unknown. SETTING:: In a U.S. cohort of HIV-infected women, we evaluated associations of BMI and waist circumference with 3 distinct CD8+ T cell phenotypes: % CD28-CD57+CD8+ T cells, % CD57+ of CD28-CD8+ T cells and % CD28- of all CD8 T cells. METHODS:: Multivariable linear regression analysis was used to estimate beta-coefficients for each of three T cell phenotypes. Covariates included HIV parameters (current and nadir CD4, current viral load), demographics (age, race, income, study site), and lifestyle (tobacco, alcohol use) factors. RESULTS:: Of 225 participants, the median age was 46 years and 50% were obese (BMI>30 m/kg). Greater BMI and waist circumference were both associated with higher %CD28-CD57+CD8+ T cells and %CD57+ of all CD28-CD8+ T cells in multivariable analysis, including adjustment for HIV viral load (all p<0.05). The association between greater BMI and the overall proportion of CD28 CD8+ cells in fully adjusted models (0.078, 95% CI: (-0.053 - 0.209) were not significant. CONCLUSIONS:: In this analysis, greater BMI and waist circumference are associated with greater expression of CD57 on CD28-CD8+ T cells and a greater proportion of CD57+CD28- CD8+ T cells. These findings may indicate that increasing BMI is immunologically protective in HIV-infected women. Future research is needed to understand the prognostic importance of these associations on clinical outcomes.

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DO - 10.1097/QAI.0000000000001376

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SN - 1525-4135

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