Higher Body Mass Index Is Associated with Greater Proportions of Effector CD8+ T Cells Expressing CD57 in Women Living with HIV

the Women's Interagency HIV Study (WIHS)

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Background: A low proportion of CD28- CD8+ T cells that express CD57 is associated with increased mortality in HIV infection. The effect of increasing body mass index (BMI) changes in the proportion of CD57+ CD28- CD8+ T cells among HIV-infected individuals on antiretroviral therapy is unknown. Setting: In a US cohort of HIV-infected women, we evaluated associations of BMI and waist circumference with 3 distinct CD8+ T cell phenotypes: % CD28- CD57+ CD8+ T cells, % CD57+ of CD28- CD8+ T cells, and % CD28- of all CD8+ T cells. Methods: Multivariable linear regression analysis was used to estimate beta coefficients for each of 3 T-cell phenotypes. Covariates included HIV parameters (current and nadir CD4, current viral load), demographics (age, race, income, and study site), and lifestyle (tobacco and alcohol use) factors. Results: Of 225 participants, the median age was 46 years and 50% were obese (BMI >30 m2/kg). Greater BMI and waist circumference were both associated with higher % CD28- CD57+ CD8+ T cells and % CD57+ of all CD28- CD8+ T cells in multivariable analysis, including adjustment for HIV viral load (all P < 0.05). The association between greater BMI and the overall proportion of CD28- CD8+ cells in fully adjusted models (0.078, 95% confidence interval: -0.053 to 0.209) was not significant. Conclusions: In this analysis, greater BMI and waist circumference are associated with greater expression of CD57 on CD28- CD8+ T cells and a greater proportion of CD57+ CD28- CD8+ T cells. These findings may indicate that increasing BMI is immunologically protective in HIV-infected women. Future research is needed to understand the prognostic importance of these associations on clinical outcomes.

Original languageEnglish (US)
Pages (from-to)e132-e141
JournalJournal of Acquired Immune Deficiency Syndromes
Volume75
Issue number5
DOIs
StatePublished - Aug 15 2017

    Fingerprint

Keywords

  • CD57
  • HIV
  • WIHS
  • immune senescence
  • obesity

ASJC Scopus subject areas

  • Infectious Diseases
  • Pharmacology (medical)

Cite this