TY - JOUR
T1 - High throughput platforms for structural genomics of integral membrane proteins
AU - Mancia, Filippo
AU - Love, James
N1 - Funding Information:
The author's contributions to the field are supported by NIH grant U54GM075026-06 .
PY - 2011/8
Y1 - 2011/8
N2 - Structural genomics approaches on integral membrane proteins have been postulated for over a decade, yet specific efforts are lagging years behind their soluble counterparts. Indeed, high throughput methodologies for production and characterization of prokaryotic integral membrane proteins are only now emerging, while large-scale efforts for eukaryotic ones are still in their infancy. Presented here is a review of recent literature on actively ongoing structural genomics of membrane protein initiatives, with a focus on those aimed at implementing interesting techniques aimed at increasing our rate of success for this class of macromolecules.
AB - Structural genomics approaches on integral membrane proteins have been postulated for over a decade, yet specific efforts are lagging years behind their soluble counterparts. Indeed, high throughput methodologies for production and characterization of prokaryotic integral membrane proteins are only now emerging, while large-scale efforts for eukaryotic ones are still in their infancy. Presented here is a review of recent literature on actively ongoing structural genomics of membrane protein initiatives, with a focus on those aimed at implementing interesting techniques aimed at increasing our rate of success for this class of macromolecules.
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U2 - 10.1016/j.sbi.2011.07.001
DO - 10.1016/j.sbi.2011.07.001
M3 - Review article
C2 - 21807498
AN - SCOPUS:80052089904
SN - 0959-440X
VL - 21
SP - 517
EP - 522
JO - Current Opinion in Structural Biology
JF - Current Opinion in Structural Biology
IS - 4
ER -