High throughput platforms for structural genomics of integral membrane proteins

Filippo Mancia, James Love

Research output: Contribution to journalReview article

19 Scopus citations

Abstract

Structural genomics approaches on integral membrane proteins have been postulated for over a decade, yet specific efforts are lagging years behind their soluble counterparts. Indeed, high throughput methodologies for production and characterization of prokaryotic integral membrane proteins are only now emerging, while large-scale efforts for eukaryotic ones are still in their infancy. Presented here is a review of recent literature on actively ongoing structural genomics of membrane protein initiatives, with a focus on those aimed at implementing interesting techniques aimed at increasing our rate of success for this class of macromolecules.

Original languageEnglish (US)
Pages (from-to)517-522
Number of pages6
JournalCurrent Opinion in Structural Biology
Volume21
Issue number4
DOIs
StatePublished - Aug 1 2011

ASJC Scopus subject areas

  • Structural Biology
  • Molecular Biology

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