High risk of human papillomavirus infection and cervical squamous intraepithelial lesions among women with symptomatic human immunodeficiency virus infection

Sten H. Vermund, Karen F. Kelley, Robert S. Klein, Anat R. Feingold, Klaus Schreiber, Gary Munk, Robert D. Burk

Research output: Contribution to journalArticle

238 Citations (Scopus)

Abstract

We investigated the relationship of human papillomavirus (by cervicovaginal lavage and Southern blot), human immunodeficiency virus, and squamous intraepithelial lesions in 96 high-risk women in the Bronx, New York. Antibodies for human immunodeficiency virus were detected in 51 (53%) women. Of the 33 women with symptomatic human immunodeficiency virus infection, 23 (70%) had human papillomavirus infection compared with 4 of 18 (22%) asymptomatic women who were human immunodeficiency virus seropositive and 10 of 45 (22%) uninfected women (p < 0.0001). The rate of squamous intraepithelial lesions was 52% (14 of 27) for women with both viruses detected, 18% (6 of 34) for women with either virus detected, and 9% (3 of 35) for uninfected women. Among symptomatic human immunodeficiency virus-infected women, a strong association between human papillomavirus infection and squamous intraepithelial lesions was demonstrated (odds ratio, 12; 95% confidence interval, 1.3 to 108). Risk was highest for younger women from ethnic or racial minority groups. Advanced human immunodeficiency virus-related disease, with its associated immunosuppression, seems to exacerbate human papillomavirus-mediated cervical cytologic abnormalities. Public health measures are needed to provide Papanicolaou smear screening and appropriate clinical follow-up and treatment for women at high risk for human immunodeficiency virus infection.

Original languageEnglish (US)
Pages (from-to)392-400
Number of pages9
JournalAmerican Journal of Obstetrics and Gynecology
Volume165
Issue number2
DOIs
StatePublished - 1991

Fingerprint

Papillomavirus Infections
Virus Diseases
HIV
Squamous Intraepithelial Lesions of the Cervix
Viruses
Papanicolaou Test
Minority Groups
Therapeutic Irrigation
Southern Blotting
Immunosuppression
Public Health
Odds Ratio
Confidence Intervals

Keywords

  • cervix
  • Human immunodeficiency virus
  • human papillomavirus
  • sexually transmitted diseases
  • squamous intraepithelial lesions

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynecology

Cite this

High risk of human papillomavirus infection and cervical squamous intraepithelial lesions among women with symptomatic human immunodeficiency virus infection. / Vermund, Sten H.; Kelley, Karen F.; Klein, Robert S.; Feingold, Anat R.; Schreiber, Klaus; Munk, Gary; Burk, Robert D.

In: American Journal of Obstetrics and Gynecology, Vol. 165, No. 2, 1991, p. 392-400.

Research output: Contribution to journalArticle

Vermund, Sten H. ; Kelley, Karen F. ; Klein, Robert S. ; Feingold, Anat R. ; Schreiber, Klaus ; Munk, Gary ; Burk, Robert D. / High risk of human papillomavirus infection and cervical squamous intraepithelial lesions among women with symptomatic human immunodeficiency virus infection. In: American Journal of Obstetrics and Gynecology. 1991 ; Vol. 165, No. 2. pp. 392-400.
@article{3203dbf9351a4528b0990fd24ee7478f,
title = "High risk of human papillomavirus infection and cervical squamous intraepithelial lesions among women with symptomatic human immunodeficiency virus infection",
abstract = "We investigated the relationship of human papillomavirus (by cervicovaginal lavage and Southern blot), human immunodeficiency virus, and squamous intraepithelial lesions in 96 high-risk women in the Bronx, New York. Antibodies for human immunodeficiency virus were detected in 51 (53{\%}) women. Of the 33 women with symptomatic human immunodeficiency virus infection, 23 (70{\%}) had human papillomavirus infection compared with 4 of 18 (22{\%}) asymptomatic women who were human immunodeficiency virus seropositive and 10 of 45 (22{\%}) uninfected women (p < 0.0001). The rate of squamous intraepithelial lesions was 52{\%} (14 of 27) for women with both viruses detected, 18{\%} (6 of 34) for women with either virus detected, and 9{\%} (3 of 35) for uninfected women. Among symptomatic human immunodeficiency virus-infected women, a strong association between human papillomavirus infection and squamous intraepithelial lesions was demonstrated (odds ratio, 12; 95{\%} confidence interval, 1.3 to 108). Risk was highest for younger women from ethnic or racial minority groups. Advanced human immunodeficiency virus-related disease, with its associated immunosuppression, seems to exacerbate human papillomavirus-mediated cervical cytologic abnormalities. Public health measures are needed to provide Papanicolaou smear screening and appropriate clinical follow-up and treatment for women at high risk for human immunodeficiency virus infection.",
keywords = "cervix, Human immunodeficiency virus, human papillomavirus, sexually transmitted diseases, squamous intraepithelial lesions",
author = "Vermund, {Sten H.} and Kelley, {Karen F.} and Klein, {Robert S.} and Feingold, {Anat R.} and Klaus Schreiber and Gary Munk and Burk, {Robert D.}",
year = "1991",
doi = "10.1016/0002-9378(91)90101-V",
language = "English (US)",
volume = "165",
pages = "392--400",
journal = "American Journal of Obstetrics and Gynecology",
issn = "0002-9378",
publisher = "Mosby Inc.",
number = "2",

}

TY - JOUR

T1 - High risk of human papillomavirus infection and cervical squamous intraepithelial lesions among women with symptomatic human immunodeficiency virus infection

AU - Vermund, Sten H.

AU - Kelley, Karen F.

AU - Klein, Robert S.

AU - Feingold, Anat R.

AU - Schreiber, Klaus

AU - Munk, Gary

AU - Burk, Robert D.

PY - 1991

Y1 - 1991

N2 - We investigated the relationship of human papillomavirus (by cervicovaginal lavage and Southern blot), human immunodeficiency virus, and squamous intraepithelial lesions in 96 high-risk women in the Bronx, New York. Antibodies for human immunodeficiency virus were detected in 51 (53%) women. Of the 33 women with symptomatic human immunodeficiency virus infection, 23 (70%) had human papillomavirus infection compared with 4 of 18 (22%) asymptomatic women who were human immunodeficiency virus seropositive and 10 of 45 (22%) uninfected women (p < 0.0001). The rate of squamous intraepithelial lesions was 52% (14 of 27) for women with both viruses detected, 18% (6 of 34) for women with either virus detected, and 9% (3 of 35) for uninfected women. Among symptomatic human immunodeficiency virus-infected women, a strong association between human papillomavirus infection and squamous intraepithelial lesions was demonstrated (odds ratio, 12; 95% confidence interval, 1.3 to 108). Risk was highest for younger women from ethnic or racial minority groups. Advanced human immunodeficiency virus-related disease, with its associated immunosuppression, seems to exacerbate human papillomavirus-mediated cervical cytologic abnormalities. Public health measures are needed to provide Papanicolaou smear screening and appropriate clinical follow-up and treatment for women at high risk for human immunodeficiency virus infection.

AB - We investigated the relationship of human papillomavirus (by cervicovaginal lavage and Southern blot), human immunodeficiency virus, and squamous intraepithelial lesions in 96 high-risk women in the Bronx, New York. Antibodies for human immunodeficiency virus were detected in 51 (53%) women. Of the 33 women with symptomatic human immunodeficiency virus infection, 23 (70%) had human papillomavirus infection compared with 4 of 18 (22%) asymptomatic women who were human immunodeficiency virus seropositive and 10 of 45 (22%) uninfected women (p < 0.0001). The rate of squamous intraepithelial lesions was 52% (14 of 27) for women with both viruses detected, 18% (6 of 34) for women with either virus detected, and 9% (3 of 35) for uninfected women. Among symptomatic human immunodeficiency virus-infected women, a strong association between human papillomavirus infection and squamous intraepithelial lesions was demonstrated (odds ratio, 12; 95% confidence interval, 1.3 to 108). Risk was highest for younger women from ethnic or racial minority groups. Advanced human immunodeficiency virus-related disease, with its associated immunosuppression, seems to exacerbate human papillomavirus-mediated cervical cytologic abnormalities. Public health measures are needed to provide Papanicolaou smear screening and appropriate clinical follow-up and treatment for women at high risk for human immunodeficiency virus infection.

KW - cervix

KW - Human immunodeficiency virus

KW - human papillomavirus

KW - sexually transmitted diseases

KW - squamous intraepithelial lesions

UR - http://www.scopus.com/inward/record.url?scp=0025861105&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025861105&partnerID=8YFLogxK

U2 - 10.1016/0002-9378(91)90101-V

DO - 10.1016/0002-9378(91)90101-V

M3 - Article

C2 - 1651648

AN - SCOPUS:0025861105

VL - 165

SP - 392

EP - 400

JO - American Journal of Obstetrics and Gynecology

JF - American Journal of Obstetrics and Gynecology

SN - 0002-9378

IS - 2

ER -