High risk neurological gait syndrome and vascular dementia

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

We defined a 'high-risk neurological gait' (HRNG) syndrome based on presence of any one of hemiparetic, frontal, and unsteady gaits, and examined its validity to predict vascular dementia (VD) over 3 and 5 years in 399 nondemented older adults, age 75 and over. Cox analysis was used to estimate hazard ratios (HR) for VD adjusted for potential confounders. At baseline, 54 subjects had HRNG. 14 subjects developed VD over 3 years and 25 by 5 years. HRNG predicted risk of VD within the first three (HR 3.3, 95% CI 1.8-5.9) and five years (HR 2.7, 95% CI 1.7-4.2). Including executive dysfunction (Digit symbol scores <16) improved validity; subjects with HRNG and executive dysfunction (HR 12.5, 95% CI 5.5-28.4) or either (HR 5.9, 95% CI 3.6-9.7) had higher risk of VD over five years. Diagnosing HRNG is a clinically relevant approach to identifying older adults at high risk of VD over short intervals.

Original languageEnglish (US)
Pages (from-to)1249-1252
Number of pages4
JournalJournal of Neural Transmission
Volume114
Issue number10
DOIs
StatePublished - Oct 2007

Fingerprint

Vascular Dementia
Gait
Neurologic Gait Disorders

Keywords

  • Dementia
  • Gait
  • Stroke
  • Vascular elementia

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

@article{5c8cd444840c4377b7b9a017761ee137,
title = "High risk neurological gait syndrome and vascular dementia",
abstract = "We defined a 'high-risk neurological gait' (HRNG) syndrome based on presence of any one of hemiparetic, frontal, and unsteady gaits, and examined its validity to predict vascular dementia (VD) over 3 and 5 years in 399 nondemented older adults, age 75 and over. Cox analysis was used to estimate hazard ratios (HR) for VD adjusted for potential confounders. At baseline, 54 subjects had HRNG. 14 subjects developed VD over 3 years and 25 by 5 years. HRNG predicted risk of VD within the first three (HR 3.3, 95{\%} CI 1.8-5.9) and five years (HR 2.7, 95{\%} CI 1.7-4.2). Including executive dysfunction (Digit symbol scores <16) improved validity; subjects with HRNG and executive dysfunction (HR 12.5, 95{\%} CI 5.5-28.4) or either (HR 5.9, 95{\%} CI 3.6-9.7) had higher risk of VD over five years. Diagnosing HRNG is a clinically relevant approach to identifying older adults at high risk of VD over short intervals.",
keywords = "Dementia, Gait, Stroke, Vascular elementia",
author = "Joe Verghese and Derby, {Carol A.} and Katz, {Mindy Joy} and Lipton, {Richard B.}",
year = "2007",
month = "10",
doi = "10.1007/s00702-007-0762-0",
language = "English (US)",
volume = "114",
pages = "1249--1252",
journal = "Journal of Neural Transmission",
issn = "0300-9564",
publisher = "Springer Verlag",
number = "10",

}

TY - JOUR

T1 - High risk neurological gait syndrome and vascular dementia

AU - Verghese, Joe

AU - Derby, Carol A.

AU - Katz, Mindy Joy

AU - Lipton, Richard B.

PY - 2007/10

Y1 - 2007/10

N2 - We defined a 'high-risk neurological gait' (HRNG) syndrome based on presence of any one of hemiparetic, frontal, and unsteady gaits, and examined its validity to predict vascular dementia (VD) over 3 and 5 years in 399 nondemented older adults, age 75 and over. Cox analysis was used to estimate hazard ratios (HR) for VD adjusted for potential confounders. At baseline, 54 subjects had HRNG. 14 subjects developed VD over 3 years and 25 by 5 years. HRNG predicted risk of VD within the first three (HR 3.3, 95% CI 1.8-5.9) and five years (HR 2.7, 95% CI 1.7-4.2). Including executive dysfunction (Digit symbol scores <16) improved validity; subjects with HRNG and executive dysfunction (HR 12.5, 95% CI 5.5-28.4) or either (HR 5.9, 95% CI 3.6-9.7) had higher risk of VD over five years. Diagnosing HRNG is a clinically relevant approach to identifying older adults at high risk of VD over short intervals.

AB - We defined a 'high-risk neurological gait' (HRNG) syndrome based on presence of any one of hemiparetic, frontal, and unsteady gaits, and examined its validity to predict vascular dementia (VD) over 3 and 5 years in 399 nondemented older adults, age 75 and over. Cox analysis was used to estimate hazard ratios (HR) for VD adjusted for potential confounders. At baseline, 54 subjects had HRNG. 14 subjects developed VD over 3 years and 25 by 5 years. HRNG predicted risk of VD within the first three (HR 3.3, 95% CI 1.8-5.9) and five years (HR 2.7, 95% CI 1.7-4.2). Including executive dysfunction (Digit symbol scores <16) improved validity; subjects with HRNG and executive dysfunction (HR 12.5, 95% CI 5.5-28.4) or either (HR 5.9, 95% CI 3.6-9.7) had higher risk of VD over five years. Diagnosing HRNG is a clinically relevant approach to identifying older adults at high risk of VD over short intervals.

KW - Dementia

KW - Gait

KW - Stroke

KW - Vascular elementia

UR - http://www.scopus.com/inward/record.url?scp=34848843522&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34848843522&partnerID=8YFLogxK

U2 - 10.1007/s00702-007-0762-0

DO - 10.1007/s00702-007-0762-0

M3 - Article

C2 - 17541695

AN - SCOPUS:34848843522

VL - 114

SP - 1249

EP - 1252

JO - Journal of Neural Transmission

JF - Journal of Neural Transmission

SN - 0300-9564

IS - 10

ER -