High-resolution mapping of 10 unique DNA sequences to human chromosome 3 subregions by in situ hybridization

Lakshmi Atchison, M. L. Atchison, L. A. Cannizzaro

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Ten single-copy DNA probes derived from a human chromosome 3-specific genomic library were mapped by in situ hybridization to subregions of this chromosome. Seven sequences were assigned to subregions of 3q and two sequences were assigned to subregions of 3p. One single-copy DNA probe was assigned to the centromeric region of chromosome 3 by Southern blot analysis of DNA isolated from a somatic cell hybrid containing centromeric sequences of this chromosome. These DNA clones mapped by in situ hybridization can provide useful landmarks for mapping various disease loci on chromosome 3. They may also be useful for the generation of physical and genetic maps.

Original languageEnglish (US)
Pages (from-to)136-138
Number of pages3
JournalCytogenetic and Genome Research
Volume71
Issue number2
DOIs
StatePublished - Jan 1 1995

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Genetics(clinical)

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