High Prevalence Rate of Human Papillomavirus Infection and Association With Abnormal Papanicolaou Smears in Sexually Active Adolescents

Walter D. Rosenfeld, Sten H. Vermund, Robert D. Burk

Research output: Contribution to journalArticle

102 Citations (Scopus)

Abstract

Human papillomaviruses (HPVs) are associated with neoplastic and malignant lesions of the uterine cervix. Cervical neoplasia is associated with onset of sexual activity at an early age. Therefore, this study sought to define the prevalence rates of HPV infection and cytologic abnormalities in adolescents. Sexually active females 13 to 21 years of age undergoing routine cervical cytologic screening were evaluated in the adolescent clinic of an urban hospital. Cells collected by cervicovaginal lavage from 249 subjects were analyzed for HPV DNA by Southern blot hybridization with probes for HPV types 6/11,16, and 18. The HPV DNA was detected in 95(38.2%) of 249 patients. Teenagers between the ages of 13 and 18 years with multiple lifetime sexual partners were at higher risk for HPV infection (38/71 [54%]) compared with patients of the same age who had only a single partner (25/74 or [34%]). Twenty (8.3%) of 241 patients had abnormal Papanicolaou smears with atypia, koilocytosis, or low-grade cervical intraepithelial neoplasia. Cytologic abnormalities were detected in 16 (17%) of 94 adolescents with HPV present, but in only 4(2.7%) of 147 of the uninfected patients. Thus, HPV emerged as a common pathogen in female adolescents, and infected patients are at increased risk for cervical epithelial abnormalities.

Original languageEnglish (US)
Pages (from-to)1443-1447
Number of pages5
JournalAmerican Journal of Diseases of Children
Volume143
Issue number12
DOIs
StatePublished - 1989

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Papanicolaou Test
Papillomavirus Infections
Human papillomavirus 11
Human papillomavirus 6
Cervical Intraepithelial Neoplasia
Sexual Partners
Therapeutic Irrigation
DNA
Urban Hospitals
Southern Blotting
Cervix Uteri
Sexual Behavior

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

High Prevalence Rate of Human Papillomavirus Infection and Association With Abnormal Papanicolaou Smears in Sexually Active Adolescents. / Rosenfeld, Walter D.; Vermund, Sten H.; Burk, Robert D.

In: American Journal of Diseases of Children, Vol. 143, No. 12, 1989, p. 1443-1447.

Research output: Contribution to journalArticle

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