High prevalence of pulmonary findings in computed tomographies of HTLV-1-infected patients with and without adult-T cell leukemia/lymphoma–implications for staging

Ana Acuna-Villaorduna, Jesus Gonzalez-Lugo, B. Hilda Ye, Diego Andres Adrianzen Herrera, R. Alejandro Sica, Urvi Shah, Nishi Shah, Noah Kornblum, Ira Braunschweig, Olga Derman, Ioannis Mantzaris, Aditi Shastri, Yanhua Wang, Amit K. Verma, Amin B. Zalta, Murali Janakiram

Research output: Contribution to journalArticle

Abstract

Lung involvement has been reported in HTLV-1 carriers and in patients with ATLL. Whether there are differences in the pattern of lung involvement between ATLL and HTLV carriers in North American patients is unknown. We aimed to compare CT pulmonary findings among patients with HTLV-1 infection with and without ATLL. Among 140 patients with HTLV-1 diagnosis, 97 had CT chest available. Of these, 72 (74.2%) had ATLL and 25 (25.8%) did not have ATLL. CT chest abnormalities were present in 90 (92.8%) participants (94.4% in ATLL; 88% in non-ATLL). Higher rates of lymphadenopathy (69.4% versus 24%, p <.01) and lower rates of bronchiectasis (25% versus 48%, p =.04) were seen in ATLL compared to non-ATLL. Our study supports that staging of lung involvement in ATLL should consider HTLV-associated pulmonary findings as not all CT chest abnormalities necessarily represent malignant infiltration.

Original languageEnglish (US)
JournalLeukemia and Lymphoma
DOIs
StatePublished - Jan 1 2019

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Adult T Cell Leukemia Lymphoma
Human T-lymphotropic virus 1
Tomography
Lung
Thorax
Deltaretrovirus Infections
Bronchiectasis

Keywords

  • ATLL
  • HTLV-1
  • T-cell lymphoma

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

Cite this

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title = "High prevalence of pulmonary findings in computed tomographies of HTLV-1-infected patients with and without adult-T cell leukemia/lymphoma–implications for staging",
abstract = "Lung involvement has been reported in HTLV-1 carriers and in patients with ATLL. Whether there are differences in the pattern of lung involvement between ATLL and HTLV carriers in North American patients is unknown. We aimed to compare CT pulmonary findings among patients with HTLV-1 infection with and without ATLL. Among 140 patients with HTLV-1 diagnosis, 97 had CT chest available. Of these, 72 (74.2{\%}) had ATLL and 25 (25.8{\%}) did not have ATLL. CT chest abnormalities were present in 90 (92.8{\%}) participants (94.4{\%} in ATLL; 88{\%} in non-ATLL). Higher rates of lymphadenopathy (69.4{\%} versus 24{\%}, p <.01) and lower rates of bronchiectasis (25{\%} versus 48{\%}, p =.04) were seen in ATLL compared to non-ATLL. Our study supports that staging of lung involvement in ATLL should consider HTLV-associated pulmonary findings as not all CT chest abnormalities necessarily represent malignant infiltration.",
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AU - Acuna-Villaorduna, Ana

AU - Gonzalez-Lugo, Jesus

AU - Ye, B. Hilda

AU - Adrianzen Herrera, Diego Andres

AU - Sica, R. Alejandro

AU - Shah, Urvi

AU - Shah, Nishi

AU - Kornblum, Noah

AU - Braunschweig, Ira

AU - Derman, Olga

AU - Mantzaris, Ioannis

AU - Shastri, Aditi

AU - Wang, Yanhua

AU - Verma, Amit K.

AU - Zalta, Amin B.

AU - Janakiram, Murali

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Lung involvement has been reported in HTLV-1 carriers and in patients with ATLL. Whether there are differences in the pattern of lung involvement between ATLL and HTLV carriers in North American patients is unknown. We aimed to compare CT pulmonary findings among patients with HTLV-1 infection with and without ATLL. Among 140 patients with HTLV-1 diagnosis, 97 had CT chest available. Of these, 72 (74.2%) had ATLL and 25 (25.8%) did not have ATLL. CT chest abnormalities were present in 90 (92.8%) participants (94.4% in ATLL; 88% in non-ATLL). Higher rates of lymphadenopathy (69.4% versus 24%, p <.01) and lower rates of bronchiectasis (25% versus 48%, p =.04) were seen in ATLL compared to non-ATLL. Our study supports that staging of lung involvement in ATLL should consider HTLV-associated pulmonary findings as not all CT chest abnormalities necessarily represent malignant infiltration.

AB - Lung involvement has been reported in HTLV-1 carriers and in patients with ATLL. Whether there are differences in the pattern of lung involvement between ATLL and HTLV carriers in North American patients is unknown. We aimed to compare CT pulmonary findings among patients with HTLV-1 infection with and without ATLL. Among 140 patients with HTLV-1 diagnosis, 97 had CT chest available. Of these, 72 (74.2%) had ATLL and 25 (25.8%) did not have ATLL. CT chest abnormalities were present in 90 (92.8%) participants (94.4% in ATLL; 88% in non-ATLL). Higher rates of lymphadenopathy (69.4% versus 24%, p <.01) and lower rates of bronchiectasis (25% versus 48%, p =.04) were seen in ATLL compared to non-ATLL. Our study supports that staging of lung involvement in ATLL should consider HTLV-associated pulmonary findings as not all CT chest abnormalities necessarily represent malignant infiltration.

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KW - HTLV-1

KW - T-cell lymphoma

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