High prevalence of high grade anal intraepithelial neoplasia in HIV-infected women screened for anal cancer

June Y. Hou, David Smotkin, Robert Grossberg, Mark Suhrland, Rebecca Levine, Harriet O. Smith, Abdissa Negassa, Thomas C. McAndrew, Mark H. Einstein

Research output: Contribution to journalArticle

15 Scopus citations


There is no consensus on optimal screening for anal cancer (AC) in HIV+ women. Seven hundred fifteen unique asymptomatic women in a high-prevalence HIV+ community were screened for AC with anal cytology and triage to high-resolution anoscopy after routine screening was implemented in a large urban hospital system. Of these, 75 (10.5%) had an abnormal anal cytology and 29 (38.7%) of those with an abnormality had high-grade anal intraepithelial neoplasia (AIN). Women with poorly controlled HIV were significantly more likely to have high-grade AIN (P = 0.03). Given the high rate of AIN in screened HIV-infected women, routine AC screening in all HIV-infected women should be strongly considered.

Original languageEnglish (US)
Pages (from-to)169-172
Number of pages4
JournalJournal of Acquired Immune Deficiency Syndromes
Issue number2
StatePublished - Jun 1 2012



  • Anal cancer screening
  • Anal cytology
  • HPV-associated disease
  • High-resolution anoscopy

ASJC Scopus subject areas

  • Infectious Diseases
  • Pharmacology (medical)

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