High prevalence of high grade anal intraepithelial neoplasia in HIV-infected women screened for anal cancer

June Y. Hou; David Smotkin; Robert Grossberg; Mark Suhrland; Rebecca Levine; Harriet O. Smith; Abdissa Negassa; Thomas C. McAndrew; Mark H. Einstein

doi:10.1097/QAI.0b013e318251afd9

High prevalence of high grade anal intraepithelial neoplasia in HIV-infected women screened for anal cancer

June Y. Hou, David Smotkin, Robert Grossberg, Mark Suhrland, Rebecca Levine, Harriet O. Smith, Abdissa Negassa, Thomas C. McAndrew, Mark H. Einstein

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

There is no consensus on optimal screening for anal cancer (AC) in HIV+ women. Seven hundred fifteen unique asymptomatic women in a high-prevalence HIV+ community were screened for AC with anal cytology and triage to high-resolution anoscopy after routine screening was implemented in a large urban hospital system. Of these, 75 (10.5%) had an abnormal anal cytology and 29 (38.7%) of those with an abnormality had high-grade anal intraepithelial neoplasia (AIN). Women with poorly controlled HIV were significantly more likely to have high-grade AIN (P = 0.03). Given the high rate of AIN in screened HIV-infected women, routine AC screening in all HIV-infected women should be strongly considered.

Original language	English (US)
Pages (from-to)	169-172
Number of pages	4
Journal	Journal of Acquired Immune Deficiency Syndromes
Volume	60
Issue number	2
DOIs	https://doi.org/10.1097/QAI.0b013e318251afd9
State	Published - Jun 1 2012

Keywords

Anal cancer screening
Anal cytology
HPV-associated disease
High-resolution anoscopy

ASJC Scopus subject areas

Infectious Diseases
Pharmacology (medical)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1097/QAI.0b013e318251afd9

Cite this

@article{36d230729710402aabe34eeed88a5baa,

title = "High prevalence of high grade anal intraepithelial neoplasia in HIV-infected women screened for anal cancer",

abstract = "There is no consensus on optimal screening for anal cancer (AC) in HIV+ women. Seven hundred fifteen unique asymptomatic women in a high-prevalence HIV+ community were screened for AC with anal cytology and triage to high-resolution anoscopy after routine screening was implemented in a large urban hospital system. Of these, 75 (10.5%) had an abnormal anal cytology and 29 (38.7%) of those with an abnormality had high-grade anal intraepithelial neoplasia (AIN). Women with poorly controlled HIV were significantly more likely to have high-grade AIN (P = 0.03). Given the high rate of AIN in screened HIV-infected women, routine AC screening in all HIV-infected women should be strongly considered.",

keywords = "Anal cancer screening, Anal cytology, HPV-associated disease, High-resolution anoscopy",

author = "Hou, {June Y.} and David Smotkin and Robert Grossberg and Mark Suhrland and Rebecca Levine and Smith, {Harriet O.} and Abdissa Negassa and McAndrew, {Thomas C.} and Einstein, {Mark H.}",

year = "2012",

month = jun,

day = "1",

doi = "10.1097/QAI.0b013e318251afd9",

language = "English (US)",

volume = "60",

pages = "169--172",

journal = "Journal of Acquired Immune Deficiency Syndromes",

issn = "1525-4135",

publisher = "Lippincott Williams and Wilkins",

number = "2",

}

TY - JOUR

T1 - High prevalence of high grade anal intraepithelial neoplasia in HIV-infected women screened for anal cancer

AU - Hou, June Y.

AU - Smotkin, David

AU - Grossberg, Robert

AU - Suhrland, Mark

AU - Levine, Rebecca

AU - Smith, Harriet O.

AU - Negassa, Abdissa

AU - McAndrew, Thomas C.

AU - Einstein, Mark H.

PY - 2012/6/1

Y1 - 2012/6/1

N2 - There is no consensus on optimal screening for anal cancer (AC) in HIV+ women. Seven hundred fifteen unique asymptomatic women in a high-prevalence HIV+ community were screened for AC with anal cytology and triage to high-resolution anoscopy after routine screening was implemented in a large urban hospital system. Of these, 75 (10.5%) had an abnormal anal cytology and 29 (38.7%) of those with an abnormality had high-grade anal intraepithelial neoplasia (AIN). Women with poorly controlled HIV were significantly more likely to have high-grade AIN (P = 0.03). Given the high rate of AIN in screened HIV-infected women, routine AC screening in all HIV-infected women should be strongly considered.

AB - There is no consensus on optimal screening for anal cancer (AC) in HIV+ women. Seven hundred fifteen unique asymptomatic women in a high-prevalence HIV+ community were screened for AC with anal cytology and triage to high-resolution anoscopy after routine screening was implemented in a large urban hospital system. Of these, 75 (10.5%) had an abnormal anal cytology and 29 (38.7%) of those with an abnormality had high-grade anal intraepithelial neoplasia (AIN). Women with poorly controlled HIV were significantly more likely to have high-grade AIN (P = 0.03). Given the high rate of AIN in screened HIV-infected women, routine AC screening in all HIV-infected women should be strongly considered.

KW - Anal cancer screening

KW - Anal cytology

KW - HPV-associated disease

KW - High-resolution anoscopy

UR - http://www.scopus.com/inward/record.url?scp=84862133399&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84862133399&partnerID=8YFLogxK

U2 - 10.1097/QAI.0b013e318251afd9

DO - 10.1097/QAI.0b013e318251afd9

M3 - Article

C2 - 22466085

AN - SCOPUS:84862133399

SN - 1525-4135

VL - 60

SP - 169

EP - 172

JO - Journal of Acquired Immune Deficiency Syndromes

JF - Journal of Acquired Immune Deficiency Syndromes

IS - 2

ER -

High prevalence of high grade anal intraepithelial neoplasia in HIV-infected women screened for anal cancer

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this