High prevalence of high grade anal intraepithelial neoplasia in HIV-infected women screened for anal cancer

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15 Citations (Scopus)

Abstract

There is no consensus on optimal screening for anal cancer (AC) in HIV+ women. Seven hundred fifteen unique asymptomatic women in a high-prevalence HIV+ community were screened for AC with anal cytology and triage to high-resolution anoscopy after routine screening was implemented in a large urban hospital system. Of these, 75 (10.5%) had an abnormal anal cytology and 29 (38.7%) of those with an abnormality had high-grade anal intraepithelial neoplasia (AIN). Women with poorly controlled HIV were significantly more likely to have high-grade AIN (P = 0.03). Given the high rate of AIN in screened HIV-infected women, routine AC screening in all HIV-infected women should be strongly considered.

Original languageEnglish (US)
Pages (from-to)169-172
Number of pages4
JournalJournal of Acquired Immune Deficiency Syndromes
Volume60
Issue number2
DOIs
StatePublished - Jun 1 2012

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Anus Neoplasms
HIV
Neoplasms
Cell Biology
Triage
Urban Hospitals
Early Detection of Cancer

Keywords

  • Anal cancer screening
  • Anal cytology
  • High-resolution anoscopy
  • HPV-associated disease

ASJC Scopus subject areas

  • Infectious Diseases
  • Pharmacology (medical)

Cite this

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title = "High prevalence of high grade anal intraepithelial neoplasia in HIV-infected women screened for anal cancer",
abstract = "There is no consensus on optimal screening for anal cancer (AC) in HIV+ women. Seven hundred fifteen unique asymptomatic women in a high-prevalence HIV+ community were screened for AC with anal cytology and triage to high-resolution anoscopy after routine screening was implemented in a large urban hospital system. Of these, 75 (10.5{\%}) had an abnormal anal cytology and 29 (38.7{\%}) of those with an abnormality had high-grade anal intraepithelial neoplasia (AIN). Women with poorly controlled HIV were significantly more likely to have high-grade AIN (P = 0.03). Given the high rate of AIN in screened HIV-infected women, routine AC screening in all HIV-infected women should be strongly considered.",
keywords = "Anal cancer screening, Anal cytology, High-resolution anoscopy, HPV-associated disease",
author = "Hou, {June Y.} and David Smotkin and Grossberg, {Robert M.} and Suhrland, {Mark J.} and Rebecca Levine and Smith, {Harriet O.} and Abdissa Negassa and McAndrew, {Thomas C.} and Einstein, {Mark H.}",
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T1 - High prevalence of high grade anal intraepithelial neoplasia in HIV-infected women screened for anal cancer

AU - Hou, June Y.

AU - Smotkin, David

AU - Grossberg, Robert M.

AU - Suhrland, Mark J.

AU - Levine, Rebecca

AU - Smith, Harriet O.

AU - Negassa, Abdissa

AU - McAndrew, Thomas C.

AU - Einstein, Mark H.

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N2 - There is no consensus on optimal screening for anal cancer (AC) in HIV+ women. Seven hundred fifteen unique asymptomatic women in a high-prevalence HIV+ community were screened for AC with anal cytology and triage to high-resolution anoscopy after routine screening was implemented in a large urban hospital system. Of these, 75 (10.5%) had an abnormal anal cytology and 29 (38.7%) of those with an abnormality had high-grade anal intraepithelial neoplasia (AIN). Women with poorly controlled HIV were significantly more likely to have high-grade AIN (P = 0.03). Given the high rate of AIN in screened HIV-infected women, routine AC screening in all HIV-infected women should be strongly considered.

AB - There is no consensus on optimal screening for anal cancer (AC) in HIV+ women. Seven hundred fifteen unique asymptomatic women in a high-prevalence HIV+ community were screened for AC with anal cytology and triage to high-resolution anoscopy after routine screening was implemented in a large urban hospital system. Of these, 75 (10.5%) had an abnormal anal cytology and 29 (38.7%) of those with an abnormality had high-grade anal intraepithelial neoplasia (AIN). Women with poorly controlled HIV were significantly more likely to have high-grade AIN (P = 0.03). Given the high rate of AIN in screened HIV-infected women, routine AC screening in all HIV-infected women should be strongly considered.

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KW - Anal cytology

KW - High-resolution anoscopy

KW - HPV-associated disease

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