TY - JOUR
T1 - High prevalence of gynecologic disease among hospitalized women with human immunodeficiency virus infection
AU - Frankel, Renée E.
AU - Selwyn, Peter A.
AU - Mezger, Jo Anne
AU - Andrews, Susan
N1 - Funding Information:
Received 5 September 1996; revised 6 May 1997. Grant support: R. E. F. was partially supported by a grant from the National Institute for Nursing Research (NR03791-01-25). Reprints or correspondence: Dr. Peter A Selwyn, Yale AIDS Program, 135 College Street, #323, New Haven, Connecticut 06510.
PY - 1997
Y1 - 1997
N2 - We offered standardized gynecologic examination to consecutive women admitted to an AIDS-designated inpatient medical service; 65 (97%) of 67 women consented to the examination. The median CD4+ T lymphocyte count was 54/mm3. Only 9% of the women were admitted to primary gynecologic or genitourinary diagnosis; however, on evaluation, 83% of these women had gynecologic disease. The overall prevalences of vaginitis, cervical dysplasia, genital condylomata, genital herpes, and pelvic inflammatory disease were 51%, 45%, 23%, 20%, and 5%, respectively. Unexpected findings included adenovirus infection and foscarnet-associated genital ulcerations (two cases each). For predicting disease, gynecologic symptoms had a sensitivity of 76% and a positive predictive value of 95% but a negative predictive value of only 41%. Our results document the high prevalence of comorbid gynecologic disease among women infected with human immunodeficiency virus (HIV). Because of the inability to fully predict disease by symptom history, it is imperative that comprehensive gynecologic evaluation be offered routinely to all HIV-infected women hospitalized for acute medical illnesses.
AB - We offered standardized gynecologic examination to consecutive women admitted to an AIDS-designated inpatient medical service; 65 (97%) of 67 women consented to the examination. The median CD4+ T lymphocyte count was 54/mm3. Only 9% of the women were admitted to primary gynecologic or genitourinary diagnosis; however, on evaluation, 83% of these women had gynecologic disease. The overall prevalences of vaginitis, cervical dysplasia, genital condylomata, genital herpes, and pelvic inflammatory disease were 51%, 45%, 23%, 20%, and 5%, respectively. Unexpected findings included adenovirus infection and foscarnet-associated genital ulcerations (two cases each). For predicting disease, gynecologic symptoms had a sensitivity of 76% and a positive predictive value of 95% but a negative predictive value of only 41%. Our results document the high prevalence of comorbid gynecologic disease among women infected with human immunodeficiency virus (HIV). Because of the inability to fully predict disease by symptom history, it is imperative that comprehensive gynecologic evaluation be offered routinely to all HIV-infected women hospitalized for acute medical illnesses.
UR - http://www.scopus.com/inward/record.url?scp=0030801855&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030801855&partnerID=8YFLogxK
U2 - 10.1086/513775
DO - 10.1086/513775
M3 - Article
C2 - 9314465
AN - SCOPUS:0030801855
SN - 1058-4838
VL - 25
SP - 706
EP - 712
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
IS - 3
ER -