High prevalence of gynecologic disease among hospitalized women with human immunodeficiency virus infection

Renée E. Frankel, Peter A. Selwyn, Jo Anne Mezger, Susan Andrews

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

We offered standardized gynecologic examination to consecutive women admitted to an AIDS-designated inpatient medical service; 65 (97%) of 67 women consented to the examination. The median CD4+ T lymphocyte count was 54/mm3. Only 9% of the women were admitted to primary gynecologic or genitourinary diagnosis; however, on evaluation, 83% of these women had gynecologic disease. The overall prevalences of vaginitis, cervical dysplasia, genital condylomata, genital herpes, and pelvic inflammatory disease were 51%, 45%, 23%, 20%, and 5%, respectively. Unexpected findings included adenovirus infection and foscarnet-associated genital ulcerations (two cases each). For predicting disease, gynecologic symptoms had a sensitivity of 76% and a positive predictive value of 95% but a negative predictive value of only 41%. Our results document the high prevalence of comorbid gynecologic disease among women infected with human immunodeficiency virus (HIV). Because of the inability to fully predict disease by symptom history, it is imperative that comprehensive gynecologic evaluation be offered routinely to all HIV-infected women hospitalized for acute medical illnesses.

Original languageEnglish (US)
Pages (from-to)706-712
Number of pages7
JournalClinical Infectious Diseases
Volume25
Issue number3
DOIs
StatePublished - 1997
Externally publishedYes

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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