High Oral Human Papillomavirus Type 16 Load Predicts Long-term Persistence in Individuals with or at Risk for HIV Infection

Daniel C. Beachler; Yingshi Guo; Wiehong Xiao; Robert D. Burk; Howard Minkoff; Howard D. Strickler; Ross D. Cranston; Dorothy J. Wiley; Lisa P. Jacobson; Kathleen M. Weber; Joseph B. Margolick; Elizabeth A. Sugar; Susheel Reddy; Maura L. Gillison; Gypsyamber D'Souza

doi:10.1093/infdis/jiv273

High Oral Human Papillomavirus Type 16 Load Predicts Long-term Persistence in Individuals with or at Risk for HIV Infection

Daniel C. Beachler, Yingshi Guo, Wiehong Xiao, Robert D. Burk, Howard Minkoff, Howard D. Strickler, Ross D. Cranston, Dorothy J. Wiley, Lisa P. Jacobson, Kathleen M. Weber, Joseph B. Margolick, Elizabeth A. Sugar, Susheel Reddy, Maura L. Gillison, Gypsyamber D'Souza

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

The association between oral human papillomavirus 16 (HPV16) DNA load and infection clearance was evaluated among 88 individuals with oral HPV16 infection who were identified within a prospective cohort of 1470 HIV-infected and uninfected individuals. Oral rinse specimens were collected semiannually for up to 5 years. The oral HPV16 load at the time of the first positive test result was significantly associated with the time to clearance of infection (continuous P trends < .01). Notably, clearance rates by 24 months were 41% and 94% in the highest and lowest HPV16 load tertiles (P = .03), respectively. High oral HPV16 load warrants consideration as a biomarker for infection persistence, the presumed precursor of HPV16-associated oropharyngeal cancer.

Original language	English (US)
Pages (from-to)	1588-1591
Number of pages	4
Journal	Journal of Infectious Diseases
Volume	212
Issue number	10
DOIs	https://doi.org/10.1093/infdis/jiv273
State	Published - Nov 15 2015

Keywords

HIV
Oral HPV
Oropharyngeal cancer
Persistence
Viral load

ASJC Scopus subject areas

General Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1093/infdis/jiv273

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Beachler, D. C., Guo, Y., Xiao, W., Burk, R. D., Minkoff, H., Strickler, H. D., Cranston, R. D., Wiley, D. J., Jacobson, L. P., Weber, K. M., Margolick, J. B., Sugar, E. A., Reddy, S., Gillison, M. L., & D'Souza, G. (2015). High Oral Human Papillomavirus Type 16 Load Predicts Long-term Persistence in Individuals with or at Risk for HIV Infection. Journal of Infectious Diseases, 212(10), 1588-1591. https://doi.org/10.1093/infdis/jiv273

Beachler, DC, Guo, Y, Xiao, W, Burk, RD, Minkoff, H, Strickler, HD, Cranston, RD, Wiley, DJ, Jacobson, LP, Weber, KM, Margolick, JB, Sugar, EA, Reddy, S, Gillison, ML & D'Souza, G 2015, 'High Oral Human Papillomavirus Type 16 Load Predicts Long-term Persistence in Individuals with or at Risk for HIV Infection', Journal of Infectious Diseases, vol. 212, no. 10, pp. 1588-1591. https://doi.org/10.1093/infdis/jiv273

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title = "High Oral Human Papillomavirus Type 16 Load Predicts Long-term Persistence in Individuals with or at Risk for HIV Infection",

abstract = "The association between oral human papillomavirus 16 (HPV16) DNA load and infection clearance was evaluated among 88 individuals with oral HPV16 infection who were identified within a prospective cohort of 1470 HIV-infected and uninfected individuals. Oral rinse specimens were collected semiannually for up to 5 years. The oral HPV16 load at the time of the first positive test result was significantly associated with the time to clearance of infection (continuous P trends < .01). Notably, clearance rates by 24 months were 41% and 94% in the highest and lowest HPV16 load tertiles (P = .03), respectively. High oral HPV16 load warrants consideration as a biomarker for infection persistence, the presumed precursor of HPV16-associated oropharyngeal cancer.",

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author = "Beachler, {Daniel C.} and Yingshi Guo and Wiehong Xiao and Burk, {Robert D.} and Howard Minkoff and Strickler, {Howard D.} and Cranston, {Ross D.} and Wiley, {Dorothy J.} and Jacobson, {Lisa P.} and Weber, {Kathleen M.} and Margolick, {Joseph B.} and Sugar, {Elizabeth A.} and Susheel Reddy and Gillison, {Maura L.} and Gypsyamber D'Souza",

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doi = "10.1093/infdis/jiv273",

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AU - Xiao, Wiehong

AU - Burk, Robert D.

AU - Minkoff, Howard

AU - Strickler, Howard D.

AU - Cranston, Ross D.

AU - Wiley, Dorothy J.

AU - Jacobson, Lisa P.

AU - Weber, Kathleen M.

AU - Margolick, Joseph B.

AU - Sugar, Elizabeth A.

AU - Reddy, Susheel

AU - Gillison, Maura L.

AU - D'Souza, Gypsyamber

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AB - The association between oral human papillomavirus 16 (HPV16) DNA load and infection clearance was evaluated among 88 individuals with oral HPV16 infection who were identified within a prospective cohort of 1470 HIV-infected and uninfected individuals. Oral rinse specimens were collected semiannually for up to 5 years. The oral HPV16 load at the time of the first positive test result was significantly associated with the time to clearance of infection (continuous P trends < .01). Notably, clearance rates by 24 months were 41% and 94% in the highest and lowest HPV16 load tertiles (P = .03), respectively. High oral HPV16 load warrants consideration as a biomarker for infection persistence, the presumed precursor of HPV16-associated oropharyngeal cancer.

KW - HIV

KW - Oral HPV

KW - Oropharyngeal cancer

KW - Persistence

KW - Viral load

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High Oral Human Papillomavirus Type 16 Load Predicts Long-term Persistence in Individuals with or at Risk for HIV Infection

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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