TY - JOUR
T1 - High Elevations of Creatine Phosphokinase in Hypothyroidism
T2 - An Isoenzyme Analysis
AU - Goldman, Joel
AU - Matz, Robert
AU - Mortimer, Robin
AU - Freeman, Ruth
PY - 1977/7/25
Y1 - 1977/7/25
N2 - In hypothyroidism, slight elevations of serum creatine phosphokinase (CPK) levels are common. In contrast, we describe six hypothyroid patients with extreme elevations (17- to 160-fold) of CPK levels. Enzyme analysis showed only MM isoenzyme in four cases and MM plus trace MB isoenzyme in two patients. Hypothyroidism should, therefore, be considered when elevated CPK levels, even if extreme, are found. Isoenzyme analysis in such a case will show primarily an MM pattern, although trace MB fraction can also be seen. This isoenzyme pattern suggests that the source of the CPK elevations is skeletal muscle.
AB - In hypothyroidism, slight elevations of serum creatine phosphokinase (CPK) levels are common. In contrast, we describe six hypothyroid patients with extreme elevations (17- to 160-fold) of CPK levels. Enzyme analysis showed only MM isoenzyme in four cases and MM plus trace MB isoenzyme in two patients. Hypothyroidism should, therefore, be considered when elevated CPK levels, even if extreme, are found. Isoenzyme analysis in such a case will show primarily an MM pattern, although trace MB fraction can also be seen. This isoenzyme pattern suggests that the source of the CPK elevations is skeletal muscle.
UR - http://www.scopus.com/inward/record.url?scp=0017740671&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0017740671&partnerID=8YFLogxK
U2 - 10.1001/jama.1977.03280040045018
DO - 10.1001/jama.1977.03280040045018
M3 - Article
C2 - 577537
AN - SCOPUS:0017740671
SN - 0098-7484
VL - 238
SP - 325
EP - 326
JO - JAMA: The Journal of the American Medical Association
JF - JAMA: The Journal of the American Medical Association
IS - 4
ER -