High elevations of creatine phosphokinase in hypothyroidism. An isoenzyme analysis

J. Goldman, R. Matz, R. Mortimer, R. Freeman

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38 Citations (Scopus)

Abstract

In hypothyroidism, slight elevations of serum creatine phosphokinase (CPK) levels are common. In contrast, the authors describe six hypothyroid patients with extreme elevations (17- to 160-fold) of CPK levels. Enzyme analysis showed only MM isoenzyme in four cases and MM plus trace MB isoenzyme in two patients. Hypothyroidism should, therefore, be considered when elevated CPK levels, even if extreme, are found. Isoenzyme analysis in such a case will show primarily an MM pattern, although trace MB fraction can also be seen. This isoenzyme pattern suggests that the source of the CPK elevations is skeletal muscle.

Original languageEnglish (US)
Pages (from-to)325-326
Number of pages2
JournalJournal of the American Medical Association
Volume238
Issue number4
DOIs
StatePublished - 1977

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Creatine Kinase
Hypothyroidism
Isoenzymes
Skeletal Muscle
Enzymes
Serum

ASJC Scopus subject areas

  • Medicine(all)

Cite this

High elevations of creatine phosphokinase in hypothyroidism. An isoenzyme analysis. / Goldman, J.; Matz, R.; Mortimer, R.; Freeman, R.

In: Journal of the American Medical Association, Vol. 238, No. 4, 1977, p. 325-326.

Research output: Contribution to journalArticle

Goldman, J. ; Matz, R. ; Mortimer, R. ; Freeman, R. / High elevations of creatine phosphokinase in hypothyroidism. An isoenzyme analysis. In: Journal of the American Medical Association. 1977 ; Vol. 238, No. 4. pp. 325-326.
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