High-dose-rate brachytherapy plus neck dissection for nodal disease

Jonathan J. Beitler, Madhur Garg, Randall P. Owen, Catherine Sarta, Richard V. Smith, Ravindra Yaparpalvi

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Background. Regional control for advanced nodal disease has been only marginally affected by concurrent chemoradiation, hyperfractionation, concomitant boost, or accelerated external radiation. Methods. Twenty-five necks in 24 patients received brachy-therapy treatment (20 Gy in 10 twice-daily fractions) in addition to external radiation, neck dissection ± chemotherapy. Indications for brachytherapy included initial treatment of bulky disease (n = 12), recurrence of neck disease in a previously treated patient with at least a 3-month disease-free interval (n = 6), persistent disease after a curative efforts (n = 4), inadequate external radiation (ie, <40 Gy) due to either intolerance or noncompliance (n = 3). Results. Overall actuarial regional control was 67% at 2 years. Regional control for those receiving brachytherapy as part of their initial treatment was 82% despite a mean nodal diameter of 8.7 cm (range, 5-15 cm). The 2-year actuarial regional control was 56% for the patients with a disease-free interval of at least 3 years. Conclusion. High-dose-rate brachytherapy produced excellent regional control.

Original languageEnglish (US)
Pages (from-to)933-938
Number of pages6
JournalHead and Neck
Volume30
Issue number7
DOIs
StatePublished - Jul 2008

Keywords

  • Brachytherapy
  • Neck disease
  • Neck dissection-regional control

ASJC Scopus subject areas

  • Otorhinolaryngology

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