TY - JOUR
T1 - High-dose naloxone in tardive dyskinesia
AU - Lindenmayer, Jean Pierre
AU - Gardner, Eliot
AU - Goldberg, Elkhonon
AU - Opler, Lewis A.
AU - Kay, Stanley R.
AU - van Praag, Herman M.
AU - Weiner, Michelle
AU - Zukin, Stephen
PY - 1988/10
Y1 - 1988/10
N2 - Tardive dyskinesia (TD) is thought to result from nigrostriatal dopaminergic supersensitivity secondary to prolonged neuroleptic exposure. Preclinical studies have demonstrated that the opiate antagonist naloxone can acutely reverse a haloperidol-induced hyperdopaminergic state. In a trial of high-dose naloxone, 20 patients with TD received i.v. naloxone (20 mg, 40 mg, and placebo) under double-blind conditions. At baseline and at regular postdrug intervals, patients were evaluated using a battery of motor, clinical, and neuropsychological measures to study effects on neurological, behavioral, and cognitive functions. There was a significant improvement in involuntary movements at 30 min postnaloxone, together with improvement in clinical ratings at that time point, as well as some cognitive changes. The implications of these findings for the putative functional relationship between dopaminergic and enkephalinergic systems in the nigrostriatal area are discussed.
AB - Tardive dyskinesia (TD) is thought to result from nigrostriatal dopaminergic supersensitivity secondary to prolonged neuroleptic exposure. Preclinical studies have demonstrated that the opiate antagonist naloxone can acutely reverse a haloperidol-induced hyperdopaminergic state. In a trial of high-dose naloxone, 20 patients with TD received i.v. naloxone (20 mg, 40 mg, and placebo) under double-blind conditions. At baseline and at regular postdrug intervals, patients were evaluated using a battery of motor, clinical, and neuropsychological measures to study effects on neurological, behavioral, and cognitive functions. There was a significant improvement in involuntary movements at 30 min postnaloxone, together with improvement in clinical ratings at that time point, as well as some cognitive changes. The implications of these findings for the putative functional relationship between dopaminergic and enkephalinergic systems in the nigrostriatal area are discussed.
KW - Tardive dyskinesia
KW - involuntary movements
KW - naloxone
KW - psychiatric symptoms
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U2 - 10.1016/0165-1781(88)90083-2
DO - 10.1016/0165-1781(88)90083-2
M3 - Article
C2 - 3070611
AN - SCOPUS:0023752382
VL - 26
SP - 19
EP - 28
JO - Psychiatry Research
JF - Psychiatry Research
SN - 0165-1781
IS - 1
ER -