TY - JOUR
T1 - High-dose carbon dioxide challenge test in anxiety disorder patients
AU - Gorman, Jack M.
AU - Papp, Laszlo A.
AU - Martinez, Jose
AU - Goetz, Raymond R.
AU - Hollander, Eric
AU - Liebowitz, Michael R.
AU - Jordan, Fanchea
N1 - Funding Information:
From the Biological Studies Unit, New York State Psychiatric Institute and D~pal~rtent of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, NY. Supported in part by MH-41778, MH-30906, Research Scientist Development Award MH-00416 (~/IG), and Physician Training in Clinical and Treatment Research Grant MH-15144 (LAP) from the National lnstitut~ of Mental Health. Address reprint requests to Dr. Gorma~t, Department of Psychiatry, Columbia University, 722 West 168th Street, New York, NY 10032. Received July 14, 1989; revised July 10, 1990.
PY - 1990/11/1
Y1 - 1990/11/1
N2 - Many investigators have shown that panic disorder patients and possibly social phobics are hypersensitive to the anxiogenic effects of inhaled carbon dioxide (CO2). In this study we administered double-breath inhalation of 35% CO2 and 65% oxygen (O2) to panic disorder patients, social phobics, and normal controls. At baseline, panic disorder patients were characterized by higher pulse, anxiety score, and evidence of hyperventilation. Panic patients and social phobics panicked more often to 35% CO2 than to room air; normal controls did not have a higher rate of panic to CO2 than to room air. However, we did not find significant group differences in anxiety level, physiological measures, or biochemical measures in response to CO2 breathing compared with room air breathing. These results confirm earlier reports of baseline hyperventilation in panic disorder patients. However, 35% CO2 may be too high a dose to differentiate respiratory responses of patients compared with normals.
AB - Many investigators have shown that panic disorder patients and possibly social phobics are hypersensitive to the anxiogenic effects of inhaled carbon dioxide (CO2). In this study we administered double-breath inhalation of 35% CO2 and 65% oxygen (O2) to panic disorder patients, social phobics, and normal controls. At baseline, panic disorder patients were characterized by higher pulse, anxiety score, and evidence of hyperventilation. Panic patients and social phobics panicked more often to 35% CO2 than to room air; normal controls did not have a higher rate of panic to CO2 than to room air. However, we did not find significant group differences in anxiety level, physiological measures, or biochemical measures in response to CO2 breathing compared with room air breathing. These results confirm earlier reports of baseline hyperventilation in panic disorder patients. However, 35% CO2 may be too high a dose to differentiate respiratory responses of patients compared with normals.
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U2 - 10.1016/0006-3223(90)90510-9
DO - 10.1016/0006-3223(90)90510-9
M3 - Article
C2 - 2124151
AN - SCOPUS:0025048357
SN - 0006-3223
VL - 28
SP - 743
EP - 757
JO - Biological Psychiatry
JF - Biological Psychiatry
IS - 9
ER -