Abstract
Collecting duct carcinoma (CDC) of the kidney is a rare malignant neoplasm of distal nephron origin. Previous studies of CDC have shown loss of heterozygosity on chromosomal arm 1q in 57% of the cases studied. To better characterize 1q loss in CDC, we performed high-density mapping of the entire long arm of chromosome 1 in 13 CDC tumor samples. We observed complete deletion of chromosomal arm 1q in 5 samples and partial deletion in 4 additional tumors. Our study further showed that the region of minimal deletion is located at 1q32.1-32.2. Sixty-nine percent (9 of 13) of the tumors showed loss of heterozygosity in this area. These data suggest that a gene or group of genes that contribute to the development of distal nephron tumors may be located within the 1q32.1-32.2 region.
Original language | English (US) |
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Pages (from-to) | 5044-5046 |
Number of pages | 3 |
Journal | Cancer research |
Volume | 56 |
Issue number | 21 |
State | Published - Nov 1 1996 |
Externally published | Yes |
ASJC Scopus subject areas
- Oncology
- Cancer Research