High-density mapping of chromosomal arm 1q in renal collecting duct carcinoma: Region of minimal deletion at 1q32.1-32.2

Gabriel Steiner, Paul Cairns, Thomas J. Polascik, Fray F. Marshall, Jonathan I. Epstein, David Sidransky, Mark P. Schoenberg

Research output: Contribution to journalArticle

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Abstract

Collecting duct carcinoma (CDC) of the kidney is a rare malignant neoplasm of distal nephron origin. Previous studies of CDC have shown loss of heterozygosity on chromosomal arm 1q in 57% of the cases studied. To better characterize 1q loss in CDC, we performed high-density mapping of the entire long arm of chromosome 1 in 13 CDC tumor samples. We observed complete deletion of chromosomal arm 1q in 5 samples and partial deletion in 4 additional tumors. Our study further showed that the region of minimal deletion is located at 1q32.1-32.2. Sixty-nine percent (9 of 13) of the tumors showed loss of heterozygosity in this area. These data suggest that a gene or group of genes that contribute to the development of distal nephron tumors may be located within the 1q32.1-32.2 region.

Original languageEnglish (US)
Pages (from-to)5044-5046
Number of pages3
JournalCancer Research
Volume56
Issue number21
StatePublished - Nov 1 1996
Externally publishedYes

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Renal Cell Carcinoma
Loss of Heterozygosity
Nephrons
Neoplasms
Chromosomes, Human, Pair 1
Genes

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Steiner, G., Cairns, P., Polascik, T. J., Marshall, F. F., Epstein, J. I., Sidransky, D., & Schoenberg, M. P. (1996). High-density mapping of chromosomal arm 1q in renal collecting duct carcinoma: Region of minimal deletion at 1q32.1-32.2. Cancer Research, 56(21), 5044-5046.

High-density mapping of chromosomal arm 1q in renal collecting duct carcinoma : Region of minimal deletion at 1q32.1-32.2. / Steiner, Gabriel; Cairns, Paul; Polascik, Thomas J.; Marshall, Fray F.; Epstein, Jonathan I.; Sidransky, David; Schoenberg, Mark P.

In: Cancer Research, Vol. 56, No. 21, 01.11.1996, p. 5044-5046.

Research output: Contribution to journalArticle

Steiner, G, Cairns, P, Polascik, TJ, Marshall, FF, Epstein, JI, Sidransky, D & Schoenberg, MP 1996, 'High-density mapping of chromosomal arm 1q in renal collecting duct carcinoma: Region of minimal deletion at 1q32.1-32.2', Cancer Research, vol. 56, no. 21, pp. 5044-5046.
Steiner G, Cairns P, Polascik TJ, Marshall FF, Epstein JI, Sidransky D et al. High-density mapping of chromosomal arm 1q in renal collecting duct carcinoma: Region of minimal deletion at 1q32.1-32.2. Cancer Research. 1996 Nov 1;56(21):5044-5046.
Steiner, Gabriel ; Cairns, Paul ; Polascik, Thomas J. ; Marshall, Fray F. ; Epstein, Jonathan I. ; Sidransky, David ; Schoenberg, Mark P. / High-density mapping of chromosomal arm 1q in renal collecting duct carcinoma : Region of minimal deletion at 1q32.1-32.2. In: Cancer Research. 1996 ; Vol. 56, No. 21. pp. 5044-5046.
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