High-density mapping of chromosomal arm 1q in renal collecting duct carcinoma: Region of minimal deletion at 1q32.1-32.2

Gabriel Steiner, Paul Cairns, Thomas J. Polascik, Fray F. Marshall, Jonathan I. Epstein, David Sidransky, Mark Schoenberg

Research output: Contribution to journalArticlepeer-review

65 Scopus citations

Abstract

Collecting duct carcinoma (CDC) of the kidney is a rare malignant neoplasm of distal nephron origin. Previous studies of CDC have shown loss of heterozygosity on chromosomal arm 1q in 57% of the cases studied. To better characterize 1q loss in CDC, we performed high-density mapping of the entire long arm of chromosome 1 in 13 CDC tumor samples. We observed complete deletion of chromosomal arm 1q in 5 samples and partial deletion in 4 additional tumors. Our study further showed that the region of minimal deletion is located at 1q32.1-32.2. Sixty-nine percent (9 of 13) of the tumors showed loss of heterozygosity in this area. These data suggest that a gene or group of genes that contribute to the development of distal nephron tumors may be located within the 1q32.1-32.2 region.

Original languageEnglish (US)
Pages (from-to)5044-5046
Number of pages3
JournalCancer research
Volume56
Issue number21
StatePublished - Nov 1 1996
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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