High-affinity anti-Gal immunoglobulin G in chronic rejection of xenografts

Uri Galili, Oktavijan P. Minanov, Robert E. Michler, Kevin R. Stone

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

The immune system in humans and monkeys responds vigorously against α-gal (α-galactosyl, Galα1-3Galβ1-4GlcNAc-R) epitopes on xenografts by producing large amounts of high-affinity anti-Gal immunoglobulin G molecules. These antibody molecules may exacerbate chronic rejection of xenografts via several mechanisms including: antibody-dependent cell cytotoxicity, chronic activation of endothelial cells, and increasing immunogenicity of xenograft-specific antigens by targeting them to antigen-presenting cells.

Original languageEnglish (US)
Pages (from-to)127-131
Number of pages5
JournalXenotransplantation
Volume4
Issue number3
StatePublished - Aug 1997
Externally publishedYes

Fingerprint

Heterografts
Immunoglobulin G
Antibody-Dependent Cell Cytotoxicity
Antigen-Presenting Cells
Haplorhini
Epitopes
Immune System
Endothelial Cells
Antigens
Antibodies

Keywords

  • Anti-Gal
  • Xenoreactive antibodies
  • Xenotransplantation

ASJC Scopus subject areas

  • Immunology

Cite this

High-affinity anti-Gal immunoglobulin G in chronic rejection of xenografts. / Galili, Uri; Minanov, Oktavijan P.; Michler, Robert E.; Stone, Kevin R.

In: Xenotransplantation, Vol. 4, No. 3, 08.1997, p. 127-131.

Research output: Contribution to journalArticle

Galili, U, Minanov, OP, Michler, RE & Stone, KR 1997, 'High-affinity anti-Gal immunoglobulin G in chronic rejection of xenografts', Xenotransplantation, vol. 4, no. 3, pp. 127-131.
Galili, Uri ; Minanov, Oktavijan P. ; Michler, Robert E. ; Stone, Kevin R. / High-affinity anti-Gal immunoglobulin G in chronic rejection of xenografts. In: Xenotransplantation. 1997 ; Vol. 4, No. 3. pp. 127-131.
@article{fc3fad395b4446538e32c929e50cdfcd,
title = "High-affinity anti-Gal immunoglobulin G in chronic rejection of xenografts",
abstract = "The immune system in humans and monkeys responds vigorously against α-gal (α-galactosyl, Galα1-3Galβ1-4GlcNAc-R) epitopes on xenografts by producing large amounts of high-affinity anti-Gal immunoglobulin G molecules. These antibody molecules may exacerbate chronic rejection of xenografts via several mechanisms including: antibody-dependent cell cytotoxicity, chronic activation of endothelial cells, and increasing immunogenicity of xenograft-specific antigens by targeting them to antigen-presenting cells.",
keywords = "Anti-Gal, Xenoreactive antibodies, Xenotransplantation",
author = "Uri Galili and Minanov, {Oktavijan P.} and Michler, {Robert E.} and Stone, {Kevin R.}",
year = "1997",
month = "8",
language = "English (US)",
volume = "4",
pages = "127--131",
journal = "Xenotransplantation",
issn = "0908-665X",
publisher = "Wiley-Blackwell",
number = "3",

}

TY - JOUR

T1 - High-affinity anti-Gal immunoglobulin G in chronic rejection of xenografts

AU - Galili, Uri

AU - Minanov, Oktavijan P.

AU - Michler, Robert E.

AU - Stone, Kevin R.

PY - 1997/8

Y1 - 1997/8

N2 - The immune system in humans and monkeys responds vigorously against α-gal (α-galactosyl, Galα1-3Galβ1-4GlcNAc-R) epitopes on xenografts by producing large amounts of high-affinity anti-Gal immunoglobulin G molecules. These antibody molecules may exacerbate chronic rejection of xenografts via several mechanisms including: antibody-dependent cell cytotoxicity, chronic activation of endothelial cells, and increasing immunogenicity of xenograft-specific antigens by targeting them to antigen-presenting cells.

AB - The immune system in humans and monkeys responds vigorously against α-gal (α-galactosyl, Galα1-3Galβ1-4GlcNAc-R) epitopes on xenografts by producing large amounts of high-affinity anti-Gal immunoglobulin G molecules. These antibody molecules may exacerbate chronic rejection of xenografts via several mechanisms including: antibody-dependent cell cytotoxicity, chronic activation of endothelial cells, and increasing immunogenicity of xenograft-specific antigens by targeting them to antigen-presenting cells.

KW - Anti-Gal

KW - Xenoreactive antibodies

KW - Xenotransplantation

UR - http://www.scopus.com/inward/record.url?scp=0001458942&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0001458942&partnerID=8YFLogxK

M3 - Article

VL - 4

SP - 127

EP - 131

JO - Xenotransplantation

JF - Xenotransplantation

SN - 0908-665X

IS - 3

ER -