High-affinity anti-Gal immunoglobulin G in chronic rejection of xenografts

Uri Galili; Oktavijan P. Minanov; Robert E. Michler; Kevin R. Stone

doi:10.1111/j.1399-3089.1997.tb00175.x

High-affinity anti-Gal immunoglobulin G in chronic rejection of xenografts

Uri Galili, Oktavijan P. Minanov, Robert E. Michler, Kevin R. Stone

Research output: Contribution to journal › Review article › peer-review

25 Scopus citations

Abstract

The immune system in humans and monkeys responds vigorously against α-gal (α-galactosyl, Galα1-3Galβ1-4GlcNAc-R) epitopes on xenografts by producing large amounts of high-affinity anti-Gal immunoglobulin G molecules. These antibody molecules may exacerbate chronic rejection of xenografts via several mechanisms including: antibody-dependent cell cytotoxicity, chronic activation of endothelial cells, and increasing immunogenicity of xenograft-specific antigens by targeting them to antigen-presenting cells.

Original language	English (US)
Pages (from-to)	127-131
Number of pages	5
Journal	Xenotransplantation
Volume	4
Issue number	3
DOIs	https://doi.org/10.1111/j.1399-3089.1997.tb00175.x
State	Published - Aug 1997
Externally published	Yes

Keywords

Anti-Gal
Xenoreactive antibodies
Xenotransplantation

ASJC Scopus subject areas

Immunology
Transplantation

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10.1111/j.1399-3089.1997.tb00175.x

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title = "High-affinity anti-Gal immunoglobulin G in chronic rejection of xenografts",

abstract = "The immune system in humans and monkeys responds vigorously against α-gal (α-galactosyl, Galα1-3Galβ1-4GlcNAc-R) epitopes on xenografts by producing large amounts of high-affinity anti-Gal immunoglobulin G molecules. These antibody molecules may exacerbate chronic rejection of xenografts via several mechanisms including: antibody-dependent cell cytotoxicity, chronic activation of endothelial cells, and increasing immunogenicity of xenograft-specific antigens by targeting them to antigen-presenting cells.",

keywords = "Anti-Gal, Xenoreactive antibodies, Xenotransplantation",

author = "Uri Galili and Minanov, {Oktavijan P.} and Michler, {Robert E.} and Stone, {Kevin R.}",

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AU - Galili, Uri

AU - Minanov, Oktavijan P.

AU - Michler, Robert E.

AU - Stone, Kevin R.

PY - 1997/8

Y1 - 1997/8

N2 - The immune system in humans and monkeys responds vigorously against α-gal (α-galactosyl, Galα1-3Galβ1-4GlcNAc-R) epitopes on xenografts by producing large amounts of high-affinity anti-Gal immunoglobulin G molecules. These antibody molecules may exacerbate chronic rejection of xenografts via several mechanisms including: antibody-dependent cell cytotoxicity, chronic activation of endothelial cells, and increasing immunogenicity of xenograft-specific antigens by targeting them to antigen-presenting cells.

AB - The immune system in humans and monkeys responds vigorously against α-gal (α-galactosyl, Galα1-3Galβ1-4GlcNAc-R) epitopes on xenografts by producing large amounts of high-affinity anti-Gal immunoglobulin G molecules. These antibody molecules may exacerbate chronic rejection of xenografts via several mechanisms including: antibody-dependent cell cytotoxicity, chronic activation of endothelial cells, and increasing immunogenicity of xenograft-specific antigens by targeting them to antigen-presenting cells.

KW - Anti-Gal

KW - Xenoreactive antibodies

KW - Xenotransplantation

UR - http://www.scopus.com/inward/record.url?scp=0001458942&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0001458942&partnerID=8YFLogxK

U2 - 10.1111/j.1399-3089.1997.tb00175.x

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M3 - Review article

AN - SCOPUS:0001458942

SN - 0908-665X

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SP - 127

EP - 131

JO - Xenotransplantation

JF - Xenotransplantation

IS - 3

ER -

High-affinity anti-Gal immunoglobulin G in chronic rejection of xenografts

Abstract

Keywords

ASJC Scopus subject areas

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