High-affinity anti-Gal immunoglobulin G in chronic rejection of xenografts

Uri Galili, Oktavijan P. Minanov, Robert E. Michler, Kevin R. Stone

Research output: Contribution to journalReview article

24 Scopus citations

Abstract

The immune system in humans and monkeys responds vigorously against α-gal (α-galactosyl, Galα1-3Galβ1-4GlcNAc-R) epitopes on xenografts by producing large amounts of high-affinity anti-Gal immunoglobulin G molecules. These antibody molecules may exacerbate chronic rejection of xenografts via several mechanisms including: antibody-dependent cell cytotoxicity, chronic activation of endothelial cells, and increasing immunogenicity of xenograft-specific antigens by targeting them to antigen-presenting cells.

Original languageEnglish (US)
Pages (from-to)127-131
Number of pages5
JournalXenotransplantation
Volume4
Issue number3
DOIs
StatePublished - Aug 1997
Externally publishedYes

Keywords

  • Anti-Gal
  • Xenoreactive antibodies
  • Xenotransplantation

ASJC Scopus subject areas

  • Immunology
  • Transplantation

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