Hierarchical linear models for the development of growth curves: An example with body mass index in overweight/obese adults

Moonseong Heo, Myles S. Faith, John W. Mott, Bernard S. Gorman, David T. Redden, David B. Allison

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

When data are available on multiple individuals measured at multiple time points that may vary in number or inter-measurement interval, hierarchical linear models (HLM) may be an ideal option. The present paper offers an applied tutorial on the use of HLM for developing growth curves depicting natural changes over time. We illustrate these methods with an example of body mass index (BMI; kg/m2 ) among overweight and obese adults. We modelled among-person variation in BMI growth curves as a function of subjects' baseline characteristics. Specifically, growth curves were modelled with two-level observations, where the first level was each time point of measurement within each individual and the second level was each individual. Four longitudinal databases with measured weight and height met the inclusion criteria and were pooled for analysis: the Framingham Heart Study (FHS); the Multiple Risk Factor Intervention Trial (MRFIT); the National Health and Nutritional Examination Survey I (NHANES-I) and its follow-up study; and the Tecumseh Mortality Follow-up Study (TMFS). Results indicated that significant quadratic patterns of the BMI growth trajectory depend primarily upon a combination of age and baseline BMI. Specifically, BMI tends to increase with time for younger people with relatively moderate obesity (25≤BMI<30) but decrease for older people regardless of degree of obesity. The gradients of these changes are inversely related to baseline BMI and do not substantially depend on gender.

Original languageEnglish (US)
Pages (from-to)1911-1942
Number of pages32
JournalStatistics in Medicine
Volume22
Issue number11
DOIs
StatePublished - Jun 15 2003
Externally publishedYes

Fingerprint

Hierarchical Linear Models
Growth Curve
Growth and Development
Linear Models
Body Mass Index
Baseline
Obesity
Growth
Nutrition Surveys
Risk Factors
Mortality
Person
Health
Inclusion
Vary
Databases
Tend
Trajectory
Gradient
Weights and Measures

Keywords

  • Body mass index
  • Growth curves
  • Hierarchical linear model
  • Obesity
  • Pooling

ASJC Scopus subject areas

  • Epidemiology

Cite this

Hierarchical linear models for the development of growth curves : An example with body mass index in overweight/obese adults. / Heo, Moonseong; Faith, Myles S.; Mott, John W.; Gorman, Bernard S.; Redden, David T.; Allison, David B.

In: Statistics in Medicine, Vol. 22, No. 11, 15.06.2003, p. 1911-1942.

Research output: Contribution to journalArticle

Heo, Moonseong ; Faith, Myles S. ; Mott, John W. ; Gorman, Bernard S. ; Redden, David T. ; Allison, David B. / Hierarchical linear models for the development of growth curves : An example with body mass index in overweight/obese adults. In: Statistics in Medicine. 2003 ; Vol. 22, No. 11. pp. 1911-1942.
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